Protein Alignment Mdr65 and LOC116406449

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_002933334.2
• Gene: LOC116406449 / 116406449
• XenbaseID: XB-GENE-29091411
• Length: 1265
• Species: Xenopus tropicalis
• Alignment Length: 1323
• Identity: 527/1323 - (39%)
• Similarity: 773/1323 - (58%)
• Gaps: 96/1323 - (7%)

  Fly     6 VSTSSSE----GKSQEEAPMAEGLEPTE---PIAFLKLFRFSTYGEIGWLFFGFI--MCCIKALT 61
            |:||::.    .|:|||..........|   |:..:::|||:.:.:|..:.||.:  |.|.....
 Frog     7 VNTSNNTDTLLDKAQEETTNVNEKSKQEQIIPVGPIQIFRFAGWLDIFLMIFGTLGAMGCGSCFP 71

  Fly    62 LPAVVIIYSEFTSMLVDRAMQFGTSSN---VHALPLFGGGKTLTNASR-------EENNE--ALY 114
            |..||                ||..:|   .|       ..:|.|:|.       ||..:  :||
 Frog    72 LMNVV----------------FGEMANSFLCH-------NSSLQNSSLCAEFKPIEEQIQLFSLY 113

  Fly   115 DDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQ 179
            ...:.:|.|         :.|...|..:.:.|.||..:||...|.||:.|:|||.|:....:...
 Frog   114 YAGLGFGAL---------VCGYLQVSFWVLTASRQTRKMRKAFFHSVLSQEIGWFDVTKSGDLNT 169

  Fly   180 SMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGK 244
            .:.:|:.||.:||.:|||||.......:..:.|....||||.|.:.:..|::.|.:...|:....
 Frog   170 RLTEDINKINNGIGDKVGHFFQNSTTCLCGILIGLIKGWKLALVILATSPVLALASAMFARILAS 234

  Fly   245 LTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLK 309
            ||.:|..:||.||.:|:|:||||||||:|||::.|::||...:..|:.....|...|..|..::.
 Frog   235 LTTKELAAYAKAGAVAQEVLSSIRTVVAFGGQEKEIKRYTENMREAKDIGIKKAVASQFSLGLVY 299

  Fly   310 SMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCA 374
            ...|.:....||||..|::.|     ..|....::..||.:.:.:..|.:.|...|:|:.|||.|
 Frog   300 GAFYSTYGLGFWYGTTLVLGD-----DAYRIGDVLAVFFNVTISSYCIGQAASHFEAFSIARGAA 359

  Fly   375 TNLFKVIDLTSKIDPLSTDG-KLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVAL 438
            .::||||...|.|:..||:| |..|  ::|::|.:::.|.|||||:|.|..|:|:.|::||||||
 Frog   360 YSIFKVIQKPSFINNFSTEGFKPDN--IKGNIELKNIHFSYPSRPDVKVLNGINLSIKSGQTVAL 422

  Fly   439 VGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISY 503
            ||.|||||||.||||||.|||..|::.:|..||:..|:::.|..|.||.||||||..||.|||.|
 Frog   423 VGQSGCGKSTIVQLLQRLYDPQEGTLAVDGHDIKSLNVRYYRELIGVVSQEPVLFGTTIKQNIKY 487

  Fly   504 GKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLD 568
            |:...|.:|||.|..:|.|::||..||:.|.:::||||:|||||||||||:||||::||||||||
 Frog   488 GREDVTDEEIEKAVKEANAYDFIMALPDKYETLVGERGAQLSGGQKQRIAVARALVRNPKILLLD 552

  Fly   569 EATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEG 633
            |||||||..||..||.|||.||||||||||:||||.|..||.||...:|.|.|:|:|.:||...|
 Frog   553 EATSALDTGSEAIVQAALDKASKGRTTIVVAHRLSTIWTADAIVVFENGAVAEQGTHSELMEKRG 617

  Fly   634 AYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIK 698
            .|:::..|..:.:.::.|    |.:|||.  .:.||:......|.:...|| :|.||
 Frog   618 IYFSLATAQTVQLSEDKE----ITETKQN--GIHEKTSLIQRFNSQASLKN-IQLEE-------- 667

  Fly   699 DTNAQSAEAPPEKPNFFR------TFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFY 757
                   |...|||:...      :|.::::|.:.||.|::||..:|...|.:.|.|::.:....
 Frog   668 -------EDEEEKPDSKEKDLPSVSFLQLMKLNRSEWPYILLGIFAAGVNGAINPLFSIFYARVI 725

  Fly   758 AALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVG 822
            |..|..|||.....:.:.|...:.::.:..:...::.|:|..:|..||.|:|.|.|.||:.|::.
 Frog   726 AVFASNDPERIRHESTIYSILFVVISVIILIAYTVRGYMFGRSGETLTMRLRHMAFKAMIQQDIA 790

  Fly   823 WFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPI 887
            ||||::|:.|||:.||:.:|.:||.|.|..|..:.:.:...|.:|.:|..|.|:::||.:|..|.
 Frog   791 WFDDKDNNTGALTTRLATDASEIQTATGSRLGLVAENVVGIILTVVIAFVYGWEMSLLAIAMAPF 855

  Fly   888 IVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIR 952
            :|.:.:||...::....|:|:.::.:.:||||::.||||:..|.||......|:|.:|:.....:
 Frog   856 VVIAGMLEFTAVAGFATRDKKQLQRSGKIATEAVDNIRTLVSLTRERTFEEMYSESLQKPYRNAQ 920

  Fly   953 QKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPA 1017
            :|....|:..:|.|:..:|.:|....:|..|:...::..:::..|...:.:|:|.|..:|:|.|.
 Frog   921 RKAHMYGMCFATGQSFMYFIHAAVFRFGAYLIRVERMNVEEVFLVFSVITFGAMTLGNTLSFAPD 985

  Fly  1018 FSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLD 1081
            ::.|:.|...||.:.:|:|.|.|     .:...::...|.| :.:|.:.|.||||.|..:|..|.
 Frog   986 YAKAMSAARYLFALFEREPTIDS-----FSQQGQKPEYFSGSLEFRNVSFNYPTRSDVAVLRDLC 1045

  Fly  1082 LEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPT 1146
            ::|..|||||.||.|||||||.||||||:|||.||.:.:|..|.: ...:..:|:::|||||||.
 Frog  1046 IKVESGQTVAFVGSSGCGKSTSVQLLQRFYDPQEGEMLLDDVDAK-CFNVQWLRSQMGIVSQEPV 1109

  Fly  1147 LFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAI 1211
            ||:.|||||||||||.|:|||.||.:|||:||.||||..||..|:|.:||:||||||||||||||
 Frog  1110 LFDCSIAENIAYGDNSRTVSMDEIQSAAKAANIHSFIQGLPLKYETLVGAKGTQLSGGQKQRIAI 1174

  Fly  1212 ARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQV 1276
            ||||:|.||||||||||||||.:||::||||||.|..|||||:|||||:||||||:|.|:..|::
 Frog  1175 ARALIRAPKILLLDEATSALDNESEKVVQQALDQARKGRTCILIAHRLTTVQNADIIVVMNKGKI 1239

  Fly  1277 VEQGNHMQLISQGGIYAKLHKTQ 1299
            :|.|:|.:|:.:.|.|..|...|
 Frog  1240 IEHGSHQELLGKHGAYYDLVNAQ 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	232/523 (44%)
		MdlB	711..1299	CDD:440747	247/594 (42%)
LOC116406449	XP_002933334.2	PTZ00265	67..1256	CDD:240339	507/1255 (40%)