Protein Alignment Mdr65 and ABCB8

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001269220.1
• Gene: ABCB8 / 11194
• HGNCID: 49
• Length: 735
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 209/601 - (34%)
• Similarity: 311/601 - (51%)
• Gaps: 65/601 - (10%)

  Fly    60 LTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILL 124
            |.|..:|.:.:::|...|...|....:.:.|.|.|:|....||                 :|.|:
Human   167 LLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLT-----------------FGYLV 214

  Fly   125 TIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIR 189
            .::.                |..|....||..||||::||||.:.|..........:..||::.:
Human   215 LLSH----------------VGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFK 263

  Fly   190 DG----ISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQ 250
            ..    ||:.:..... |.|.::::::   ...:|||.:....|.::.:...:.....||:.:.|
Human   264 SSFKLVISQGLRSCTQ-VAGCLVSLSM---LSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQ 324

  Fly   251 ESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKG----AFSGLSDAVLKSM 311
            |..|.|..:|:|.|.::|||.:|..|:.|.:||...|...|..::..|    .|.|||:.....|
Human   325 EQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCM 389

  Fly   312 LYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESF--ATARG-- 372
            :    .|..:.|.:|      |..::.|...||    ..:|.:..:.|:...|...  ...||
Human   390 V----LGTLFIGGSL------VAGQQLTGGDLM----SFLVASQTVQRSMANLSVLFGQVVRGLS 440

  Fly   373 CATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVA 437
            ....:|:.:.|...| |||....:....|||.|.||:|.|.||.||...|.:...:.:..|:.||
Human   441 AGARVFEYMALNPCI-PLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVA 504

  Fly   438 LVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSN-IAVVGQEPVLFLGTIAQNI 501
            |||.||.||:|...||:|||||..|.|:||..|:|..:..|||.. :..:.||||||..||.:||
Human   505 LVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENI 569

  Fly   502 SYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILL 566
            .:||..|:.:|:..||.:|.||||||:.||.|.:::||||:.||||||||:|||||||:.|.:|:
Human   570 RFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLI 634

  Fly   567 LDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMAL 631
            |||||||||.:||:.||:|||.||.|||.:|::||||.:|||..||.:.||:|.|.|:|::|:..
Human   635 LDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKK 699

  Fly   632 EGAYYNMVRAGDINMP 647
            .|.|..::|...::.|
Human   700 GGLYAELIRRQALDAP 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	195/535 (36%)
		MdlB	711..1299	CDD:440747
ABCB8	NP_001269220.1	MdlB	134..714	CDD:440747	208/598 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	712..735		1/4 (25%)