Protein Alignment Mdr65 and abcb11

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_031749510.1
• Gene: abcb11 / 100489744
• XenbaseID: XB-GENE-29079871
• Length: 1296
• Species: Xenopus tropicalis
• Alignment Length: 1305
• Identity: 511/1305 - (39%)
• Similarity: 765/1305 - (58%)
• Gaps: 67/1305 - (5%)

  Fly    31 IAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLV--DRAMQ----------- 82
            :.|.:||||::..:...:..|.:...|.....|.:::||...|...:  ||..|
 Frog    17 VGFFQLFRFASATDKVMMVIGALCALIHGAAQPLMLLIYGMMTDTFITYDRETQELQDINKECIN 81

  Fly    83 ------FGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDV 141
                  .||...|....:..|    ||..::....|.|  .|..||::.:.|       .|.:.:
 Frog    82 DTIWWKNGTEYIVDNSTVACG----TNIEKKMTEFAYY--YIGIGIIVLVLS-------YFQISL 133

  Fly   142 FNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGF 206
            :.:.|.||:..:|.:.|..::|.||||.|..|.......:.||:.||.:.|:::|..|:..:..|
 Frog   134 WVVAAARQIQIVRKEYFRKIMRLDIGWFDSNSVGELNTRISDDINKINNAIADQVAIFIERISTF 198

  Fly   207 IITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVV 271
            |....|.|...|||||.:.:..||:.|....:|....:||.||.::||.||::|:|:||:||||.
 Frog   199 IFGFLIGFVGNWKLTLVIVAVSPLIGLGAGLMAVAVARLTGRELKAYAKAGSVADEVLSAIRTVA 263

  Fly   272 SFGGEKSEVQRYENFLVPARKASQW---KGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNV 333
            :|||||.|.:||::.|   .:|..|   ||...|.....:..:::|..:.|||||..|:|
 Frog   264 AFGGEKKEAERYDDNL---EEAQTWGIRKGTIIGFFQGYMWCIIFLCYSLAFWYGSRLVI----- 320

  Fly   334 ENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLN 398
            |.:|.:|..|:..|||::|.|.|:.:.:|.||:||:.|..||.:::.|||...||.:|.:|..|:
 Frog   321 ETRELSPGSLLQVFFGVLVAAMNLGQASPCLEAFASGRAAATIIYETIDLNPVIDCMSEEGHKLD 385

  Fly   399 YGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGS 463
            . ::||:||.:|.|.|||||::.....|:|.|:.|:|.|.||.||.|||:.|||:||||||..|.
 Frog   386 Q-VKGDIEFHNVNFCYPSRPDIKSLSDLSISIKPGETTAFVGPSGSGKSSAVQLIQRFYDPTDGK 449

  Fly   464 VLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITN 528
            |.||..|:|..|.:||||.|.:|.||||||..|||:|||||:.|.|..:||.||..|.|:.||.:
 Frog   450 VTLDGHDLRTLNTKWLRSLIGIVEQEPVLFATTIAENISYGRDGVTMNDIEKAAKDANAYNFIMD 514

  Fly   529 LPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGR 593
            ||:.:.:::||.|.|:|||||||||||||||:||||||||.||||||.:||..||:||:....||
 Frog   515 LPQKFDTLVGEGGGQMSGGQKQRIAIARALIRNPKILLLDMATSALDNESEAIVQEALNKVQSGR 579

  Fly   594 TTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVEKEDSIED 658
            |||.::||||.:|.||.||....|:.:|:|:|::||.|:|.|:.:|...:.| ....||..:.:.
 Frog   580 TTISIAHRLSTVRTADIIVGFDGGRAVEKGNHEELMKLKGVYFTLVTLQNQN-NSSAEKTATEDV 643

  Fly   659 TKQKSLALFEKSFETSPLNF----EKGQKNSV----------QFEEPIIKALIKDTNAQSAEAPP 709
            ..:|.......|:.:|..|.    .|.|.:::          ....|:...:::....:..|...
 Frog   644 AAEKEKPFIRGSYRSSLRNTLRLRSKSQLSNIFPVPLSGTVNGTAVPVEDEIMEPVETKEKEKKK 708

  Fly   710 EKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAV 774
            .|.| .....|:|:...:||.||::|:|.|...|.:.|.:|::|.:.....:..|..:..|....
 Frog   709 GKKN-KSVIGRVLKYNTKEWPYLLVGSIGAAINGVVTPLYAILFSQILGTFSLPDLNEQRREING 772

  Fly   775 LSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLS 839
            :....:.:|.::.:..|.|.|.|..:|..||.|:|.:.|.||:.||:|||||.|||.|||:.||:
 Frog   773 ICILFVIIAVVSFVTQFFQGYAFAKSGERLTRRLRRVGFQAMLGQEIGWFDDNNNSPGALTTRLA 837

  Fly   840 GEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVV 904
            .:|..:|||.|..:..::.:|:|..:|:.:|.|::|||:|:.|...|::..:.:.:|||::....
 Frog   838 TDASQVQGATGSQIGMVVNSLTNIGASLIIAFYFSWKLSLVVLCFLPLLALAGVFQAKMLTGFAN 902

  Fly   905 REKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASA 969
            ::|..:|.|.::::|:|.||||||||.:|...:..|.::::.......:|....|......|...
 Frog   903 QDKNALEMAGKVSSEAIGNIRTVAGLGKETMFVEVYEKQLELPYKAAVKKSHVYGACFGFAQCVI 967

  Fly   970 FFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDR 1034
            |.|||.:..:||.||:...:.:..:.:|...::.....|.::.:|||.::.|.||..:.|::|||
 Frog   968 FMAYAASFRFGGFLVNTDGIHYAVVFRVISAIVTSGTALGRASSFTPDYAKAKIAAEQFFKLLDR 1032

  Fly  1035 KPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGC 1098
            .||.     ::.::...:...|:| :.:...:|.||:||...:|.||.:.|..|||:|.||.|||
 Frog  1033 VPKT-----SVFSSSGDKWEEFKGDIEFVNCKFTYPSRPVTMVLRGLSISVRSGQTLAFVGSSGC 1092

  Fly  1099 GKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRR 1163
            ||||.||||:|:||||||.:.:| .....::.:..:|:|:|||||||.|||.|||:||.||||.|
 Frog  1093 GKSTSVQLLERFYDPDEGKVLVD-GHATANVNISFLRSKIGIVSQEPVLFEGSIADNIKYGDNSR 1156

  Fly  1164 SVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEAT 1228
            .:.|.|:|.|||.|:.|.|:::||:.|:|.:|.:|:|||.|||||||||||:||:||||||||||
 Frog  1157 DIPMEEVIEAAKKAHLHEFVMTLPDQYETNVGIQGSQLSRGQKQRIAIARAIVRDPKILLLDEAT 1221

  Fly  1229 SALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYA 1293
            ||||.:||:.||.|||.|..|||||.|||||||:|..|:|.|:..|.:||:|:|..|::..|.|.
 Frog  1222 SALDTESEKTVQAALDEARKGRTCIAIAHRLSTIQTCDIIAVMSQGAIVEKGSHEALMALKGAYY 1286

  Fly  1294 KLHKT 1298
            ||..|
 Frog  1287 KLVTT 1291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	236/525 (45%)
		MdlB	711..1299	CDD:440747	242/589 (41%)
abcb11	XP_031749510.1	PTZ00265	16..1287	CDD:240339	508/1299 (39%)