Protein Alignment Mdr65 and LOC100485969

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_031758323.1
• Gene: LOC100485969 / 100485969
• XenbaseID: XB-GENE-29078075
• Length: 1262
• Species: Xenopus tropicalis
• Alignment Length: 1309
• Identity: 543/1309 - (41%)
• Similarity: 786/1309 - (60%)
• Gaps: 67/1309 - (5%)

  Fly     4 DEVSTSSSE-----GKSQEEAPMAE--GLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALT 61
            |.::..::|     .|:|::..:.|  ..|..:.:..:::|||:...:|..:..|.|......|.
 Frog     5 DPINMGNNEEEKCKDKAQDDTVIEEKKEREKQKAVGVIQIFRFADKLDIFLMVIGLIGAAGNGLC 69

  Fly    62 LPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTI 126
            ||.:.::|.:.|    |..:.|.:|              :.|:|.....:.|.:....:.:....
 Frog    70 LPMLNLVYGQVT----DSILCFNSS--------------IQNSSECNKFKPLGEQMTIFALYYVA 116

  Fly   127 ASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDG 191
            ....:.:||...|..:.:.|.||..:||...|.||:.|::.|.|:.........:.:|:.||.||
 Frog   117 IGAAVIVSGYAQVSFWVLAAARQTRKMRQAFFRSVLSQEMSWFDINKSGEINTRLNEDITKINDG 181

  Fly   192 ISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGA 256
            |.:|:||....|..||..:.::.:.||:|.|...:..||:.|...:.:|....||::|..:||.|
 Frog   182 IGDKIGHLFQNVSTFIAGIIVALATGWELALVYIAASPLIALSAAFCSKMLVSLTSKELSAYAAA 246

  Fly   257 GNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFW 321
            |.:|||:||||||||:|||::.|::||.|.|..|:|....:...|.|:..::...:|.|....||
 Frog   247 GAVAEEVLSSIRTVVAFGGQEREIKRYTNNLEEAKKIGIKRAIVSQLALGLVFLFIYCSYGLGFW 311

  Fly   322 YGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSK 386
            ||..:|:     :||.||....::.||.:...:..|.:.:...|:|:.|||.|..:|.|:|.|:.
 Frog   312 YGTIVIL-----QNKGYTIGDALVIFFSVANSSFCIGQASSHFEAFSIARGAAYKIFNVMDQTAT 371

  Fly   387 IDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQ 451
            ||...|:|.... .::|:|||::|.|.|||||.|.:.:|||::|::||||||||.|||||||.||
 Frog   372 IDNYMTEGHRPE-NMKGNVEFKNVSFSYPSRPNVQILKGLNLKIKSGQTVALVGQSGCGKSTTVQ 435

  Fly   452 LLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAA 516
            ||||.||...|:|.:|..|||..|:...|..|.||.||||||..||..||.||:...|..|||.|
 Frog   436 LLQRLYDAQEGTVTVDGHDIRSLNVGHYREFIGVVSQEPVLFGTTIKNNIKYGRENVTDLEIEKA 500

  Fly   517 ATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQ 581
            ..:|.|::||..||:.|.:::||||:||||||||||||||||::|||||||||||||||.:||..
 Frog   501 VKEANAYDFIMALPDKYDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESESV 565

  Fly   582 VQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINM 646
            ||.||:.||.||||||::||||.:..||.||.|.:|.|.|:|:|.:||..:|.|:::|.|..|:.
 Frog   566 VQDALEKASAGRTTIVIAHRLSTVWTADVIVVIENGAVAEQGTHKELMEKKGIYHSLVTAQSIDA 630

  Fly   647 PDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEK 711
            .:..::.::.::..:|...:...|.:.|        ..|...||...|..:|:      |:.| |
 Frog   631 AETDKQTETAQEMNRKPSLVKRLSSKIS--------TRSEHLEEEEEKEDVKE------ESLP-K 680

  Fly   712 PNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLS 776
            .:||    :||.|.|.||.|:::||::|:..|..:|||.:.|.:..|..:..|||...|...:.|
 Frog   681 VSFF----KILNLNKSEWPYILIGTLAAIINGGAHPAFCIFFAKVSAVFSTNDPERIQREANLYS 741

  Fly   777 --WACLG-LAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARL 838
              :|.:| ::|||   .|||.::|..:|..||.|:|.|.|.||:.||:.||||:.||.|||:.||
 Frog   742 IIFAVIGVISFLT---YFLQGFMFGRSGEVLTMRVRQMAFKAMLRQEMSWFDDKKNSTGALTTRL 803

  Fly   839 SGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAV 903
            :.:|..||.|.|..|..:.:.::....||.:|..|.|:|.||.||..|.|:.:.:||...::...
 Frog   804 ATDASQIQMATGSRLGLIAENVACMGLSVIIAFVYGWELTLLILAMTPFIIVTGLLETSALTGFA 868

  Fly   904 VREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQAS 968
            .|:|:.::.|.:||.|::.|||||..|.||......|.|.:|:.....:::.:..|:..:..|:.
 Frog   869 NRDKKELQVAGKIAAETVDNIRTVISLTRERAFEEMYAESLQKPYRNSQKRAQVYGICFALSQSF 933

  Fly   969 AFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILD 1033
            .:|:||....:||:::..|:...:::|.|...:.||:|.:.|||:|.|.:|.|..|...||.:.:
 Frog   934 IYFSYAATFRFGGLMLELGRTNSEELILVFAIVTYGAMSVGQSLSFAPDYSKAKSAASHLFALFE 998

  Fly  1034 RKPKIQS--PMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGH 1095
            |:|.|.|  ..|....|       |:| |..|.:.|.||:|||..:|.||.:::..|||||.||.
 Frog   999 REPAIDSYCQQGQKPET-------FQGSVELRKVSFNYPSRPDVPVLQGLSIKIQSGQTVAFVGS 1056

  Fly  1096 SGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGD 1160
            |||||||.||||||:|||.:|.:..|:.|.: .|.:..:|:::.||||||.||:.||||||||||
 Frog  1057 SGCGKSTSVQLLQRFYDPYQGDVLFDNLDAK-CLNIQWLRSQIAIVSQEPVLFDCSIAENIAYGD 1120

  Fly  1161 NRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLD 1225
            |.|:|.|.||..|||:||.||||..||..|:|::|.:||||||||||||||||||||.||:||||
 Frog  1121 NSRAVPMEEIQRAAKAANIHSFIEGLPEKYNTKVGGKGTQLSGGQKQRIAIARALVRKPKLLLLD 1185

  Fly  1226 EATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGG 1290
            |||||||.:||::||||||.|..|||||:||||||||||||||.|::||:::|.|||.||:::.|
 Frog  1186 EATSALDNESEKIVQQALDQARQGRTCILIAHRLSTVQNADVIVVMKNGRIIELGNHQQLLAKRG 1250

  Fly  1291 IYAKLHKTQ 1299
            .|..|...|
 Frog  1251 TYFDLVNAQ 1259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	234/522 (45%)
		MdlB	711..1299	CDD:440747	273/593 (46%)
LOC100485969	XP_031758323.1	PTZ00265	103..1252	CDD:240339	518/1184 (44%)