Protein Alignment Mdr65 and tap1

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_002665053.1
• Gene: tap1 / 100333043
• ZFINID: ZDB-GENE-050517-43
• Length: 731
• Species: Danio rerio
• Alignment Length: 625
• Identity: 203/625 - (32%)
• Similarity: 326/625 - (52%)
• Gaps: 78/625 - (12%)

  Fly    31 IAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLF 95
            :.::|.|.    |....:||..::..:..:.:|       .:|..:.|..|
Zfish   152 LGYMKPFS----GRFAAVFFFVVISSLGEMAIP-------HYTGKMTDWIM-------------- 191

  Fly    96 GGGKTLTNASREENNEALYDDSISYGILLTIASVVM-FISGIFSVDVFNMVALRQVTRMRIKLFS 159
                      .|:..|| ::.:|:...|:||.|.|. |:..:    ::|:...|..|.::..:|.
Zfish   192 ----------NEDEPEA-FNHAITVMTLMTIMSAVCEFVCDL----IYNITMSRIHTSIQGLVFQ 241

  Fly   160 SVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAV 224
            :|::|||.:.|.|:..:....:..|...:.:.:|||:.    |::.:.:.|...|.....|:..:
Zfish   242 AVLKQDIAFFDKATTGDIVSRITTDTNTMSESLSEKLS----LLMWYFMRVIFLFGSMLMLSTRL 302

  Fly   225 SSY----IPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYEN 285
            ..:    :|::.::.....:|..||:|:.|:|.|.|..:|.|..||::||.||..|..|.:||..
Zfish   303 CCFTLLGLPVIWIIPEIFGRFYQKLSAQVQDSLAKANEVATETFSSMKTVRSFANEDGETERYRK 367

  Fly   286 FL----------VPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTP 340
            .|          ..|...|.|..:.|.|  |:..|:||        ||..|:... :|.:.:...
Zfish   368 CLEDTFALNKVEAAAYAVSTWTNSMSSL--ALKVSILY--------YGGRLVTGS-DVSSGDLVS 421

  Fly   341 AILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDV 405
            .:|....|...|  :.:....|.::.   |.|.:..:|:.:|....:.|   ||.|....|:|.|
Zfish   422 FVLYELQFTSAV--EVLMSYWPHVKK---AVGASEKIFEYVDRKPDVPP---DGSLAPKTLKGHV 478

  Fly   406 EFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLD 470
            :|::|.|.||.||:..|.:.:::.::||:..||||.||.||:|.|.||:|||.|..|.:|||...
Zfish   479 QFRNVTFAYPKRPDTDVLKNVSLELKAGKITALVGPSGSGKTTVVSLLERFYQPQNGEILLDQKP 543

  Fly   471 IRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRS 535
            :..|..|:|...|:||.||||||..::.:||.|||..||.:||.|||..|.||:||::||:.|.:
Zfish   544 LLSYKDQYLHEKISVVSQEPVLFARSVRENIKYGKENATNEEIYAAARLANAHDFISSLPKGYDT 608

  Fly   536 MIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSH 600
            ..||:|.|:||||||||||||||||.|:||:||:|||:||.:||.:|..||....:..|.:::||
Zfish   609 DAGEKGGQVSGGQKQRIAIARALIQKPQILVLDDATSSLDTESEHRVYSALKKELQSCTVLLISH 673

  Fly   601 RLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVR 640
            |||.:..||.|:|:.:|:::|||:|..|:..:|.|...|:
Zfish   674 RLSGVENADHILFLREGELVEEGNHQQLLDKQGFYAEFVK 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	191/538 (36%)
		MdlB	711..1299	CDD:440747
tap1	XP_002665053.1	3a01208	42..712	CDD:273363	202/622 (32%)