Protein Alignment Mdr65 and abcb8

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001121515.1
• Gene: abcb8 / 100158634
• XenbaseID: XB-GENE-1010256
• Length: 688
• Species: Xenopus tropicalis
• Alignment Length: 634
• Identity: 218/634 - (34%)
• Similarity: 320/634 - (50%)
• Gaps: 86/634 - (13%)

  Fly    55 CCIKALTLPAVV-----------------IIYSEFTSMLVDRAMQFGTSSNVHALPLFGGG--KT 100
            |.::.:..|.:|                 ::..:..::|....:.||.:.....:||..|.  ..
 Frog    83 CQVELIAPPLIVPQGARPEPEFNWAEFWKLLRPQLIALLTAVLLAFGAALLNIRIPLMLGELVNV 147

  Fly   101 LTNASREENNEALYDDS-------ISYGI--LLTIASVVMFISGIFSVDVFNMVALRQVTRMRIK 156
            ::..:||.....|.:..       ..||.  |||...:|:          .:.|..|....||..
 Frog   148 VSRYTREHAGNYLQEVQGPALKLLCLYGAQGLLTCGYIVL----------LSRVGERVAGSMRKS 202

  Fly   157 LFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRD-----------GISEKVGHFVYLVVGFIITV 210
            ||.|::|||:.:.|..........:..||::.:.           .:::.||.|:.|
 Frog   203 LFFSLLRQDVAFFDAEKTGLLVNRLTSDVQEFKSSFKQVISQGLRSLTQTVGCFLSL-------- 259

  Fly   211 AISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGG 275
               :....|||..:...:|:::.....:..|..||:.|.||..|.|..||:|.|.::|||.:|..
 Frog   260 ---YYISPKLTGLLLVVMPVLVGSGALIGSFLRKLSRRAQEQVARATGLADEALGNVRTVKAFAM 321

  Fly   276 EKSEVQRYENFLVPARKASQWKG----AFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENK 336
            |..|::.|...:..:...::..|    .|.|||:.||..::    .|..:.|.:|      :.:|
 Frog   322 ESREMELYSAEVDKSSGQNEVLGVGIAVFQGLSNVVLNCIV----LGTIFAGGSL------MSSK 376

  Fly   337 EYTPAILMIAFFGIIVGADNIARTAPFLESF--ATARGCAT--NLFKVIDLTSKIDPLSTDGKLL 397
            |.:...||    ..:|.:..:.|:...:...  ...||.:.  .:|:.:.|...| |||...||
 Frog   377 ELSAGELM----SFLVASQTVQRSMANMSVLFGQVVRGLSAGGRVFEFMSLEPTI-PLSGGFKL- 435

  Fly   398 NYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFG 462
             ..|||::.|:||.|.||:||...|.|..::||..|:||||||.||.||||...||:|||||..|
 Frog   436 -PVLRGEIHFKDVSFSYPTRPGHEVLRSFDLRIPHGKTVALVGQSGGGKSTVAALLERFYDPTEG 499

  Fly   463 SVLLDDLDIRKYNIQWLRSN-IAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFI 526
            :|.||.:|||..:..|||.. |..:.||||||..||.:||.:|:|.||..|:..||.||.|..||
 Frog   500 AVQLDGVDIRILDPSWLRGEVIGFINQEPVLFGTTIIENIRFGRPDATDAEVHEAAIQANADSFI 564

  Fly   527 TNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASK 591
            .:.||.|.:|:||||..||||||||:||||||:::||||:|||||||||.:||:.||.|||.|..
 Frog   565 RSFPEGYNTMLGERGVTLSGGQKQRVAIARALLKDPKILILDEATSALDTESERAVQVALDRARS 629

  Fly   592 GRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVR 640
            |||.:|::||||.|..||.||.:..|:|.|.|:|.||:...|.|.:::|
 Frog   630 GRTVLVIAHRLSTISEADFIVVLSKGQVAEFGTHQDLLRRGGLYADLIR 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	206/545 (38%)
		MdlB	711..1299	CDD:440747
abcb8	NP_001121515.1	MdlB	106..684	CDD:440747	215/611 (35%)