Protein Alignment Mdr65 and abcb10

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_001343218.3
• Gene: abcb10 / 100003744
• ZFINID: ZDB-GENE-040525-2
• Length: 710
• Species: Danio rerio
• Alignment Length: 672
• Identity: 228/672 - (33%)
• Similarity: 357/672 - (53%)
• Gaps: 94/672 - (13%)

  Fly   664 LALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLA-KQ 727
            :||:..|.:::..:      .||..:|...|     |.|.|...|.|      ...::|||| .|
Zfish    84 VALYSTSTDSNQTS------KSVVNQESSAK-----TTADSLPVPSE------DVKKLLQLAHPQ 131

  Fly   728 EWCYLILGTISAVAVGFLYPAFAV------IFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLT 786
            .|      .::| |||||..:..|      ..|:....:.....||.   ::.|:..||   .||
Zfish   132 RW------RLTA-AVGFLVISSTVTMSAPFFLGKVIDTIYTSPTEDF---SSSLTSLCL---MLT 183

  Fly   787 GLVCFL--------QTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAV 843
            |:  ||        :.||...:|..:..::|...|::::.||:|:||  ....|.|..|||.:..
Zfish   184 GV--FLCGGAANAARVYLMQISGQQIVRKLRESLFSSILKQELGFFD--KTRTGELINRLSADTA 244

  Fly   844 DIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQ 908
            .:...:...||..:::|:...:.|.:.:|.:..||...|...|.|....::..:.:.:...|.:.
Zfish   245 IVGRCLTDNLSDGLRSLAQAGAGVGMMLYVSPSLAAFVLMVVPPIACLAVIFGRFLRSISRRTQD 309

  Fly   909 VIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAY 973
            .:.||.::|.|.|:|:|||....:|...:::|::::..:..|.:::         .:.::.|:..
Zfish   310 ALAEATQLAEERISNLRTVRAFGKELTEVQKYSQKVDHIFELAKKE---------AVVSAGFYGV 365

  Fly   974 A--------VALCY-GGVLVSE-----GQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALI- 1023
            .        :::.| ||:|::.     |||        |..|:| :..:..|:|...:|.:.|:
Zfish   366 TGLSGNVIILSVLYKGGLLMASEAMTVGQL--------SSFLMY-AFWVGISIAGFSSFYSELMK 421

  Fly  1024 ---AGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEV 1084
               ||.||::::||||:.....|.:..:     .|.:| :.:|.:.|.||||.|:.|...|.|.|
Zfish   422 GLGAGTRLWELIDRKPEFPLNEGLVLTS-----ELLKGELEFRNVSFAYPTRKDSPIFQDLSLHV 481

  Fly  1085 LKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFE 1149
            ..|..:|:||.||.|||:.|.||.|.||||.|.:.:|..||: ||....:|:.:|.|||||.||.
Zfish   482 PAGSVLAVVGSSGSGKSSLVSLLLRLYDPDSGIVSVDGHDIR-DLNPYWLRSHIGTVSQEPVLFS 545

  Fly  1150 RSIAENIAYG-DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIAR 1213
            .||||||||| .:...|::.:|..||:.||||.||...|.||||.:|.:|..||||||||:||||
Zfish   546 CSIAENIAYGAPDPSQVTVEDIYRAAQIANAHDFIQEFPKGYDTVVGEKGVLLSGGQKQRVAIAR 610

  Fly  1214 ALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVE 1278
            ||::|||||||||||||||.::|.|||:||:....|||.::|||||||:|:||.:.|:...:|:|
Zfish   611 ALLKNPKILLLDEATSALDAENEFLVQEALERLMDGRTVLIIAHRLSTIQSADSVAVLDQHRVME 675

  Fly  1279 QGNHMQLISQG-GIYAKLHKTQ 1299
            .|:|.||::.. |::.||.:.|
Zfish   676 IGSHSQLLANDQGLFRKLMEKQ 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747
		MdlB	711..1299	CDD:440747	215/623 (35%)
abcb10	XP_001343218.3	MdlB	122..698	CDD:440747	216/617 (35%)