Protein Alignment CG10274 and topi

DIOPT Version :10

• Sequence 1: NP_001097525.1
• Gene: CG10274 / 38716
• FlyBaseID: FBgn0035690
• Length: 863
• Species: Drosophila melanogaster
• Sequence 2: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 874
• Identity: 172/874 - (19%)
• Similarity: 264/874 - (30%)
• Gaps: 300/874 - (34%)

  Fly    90 DMVARNVFCPPASAQMKNFDLLNVAGNEPELVGQDEEDRINFDPLLDHKMEMIENEEDVFK---- 150
            |:|.......||..|     :|..|..:.....|.|:.:|. |.|.......:..|:.||.
  Fly    69 DVVVERTLADPAFKQ-----ILQEADGKKGFDPQAEQMKIR-DFLAGVTSSKMTTEQSVFHGSRS 127

  Fly   151 ----------------------MLEHVDKEAEQVEKEVKQDELDAADLMTIFAAESSEESEEDID 193
                                  ..::...||:.:|..|.|.|  ...|:...:|..:..|:
  Fly   128 NSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQE--KPHLVPTVSAPPAPLSK---- 186

  Fly   194 QDVDFEPNSSDGDDDVPLAQR-LRDNSRMIPKAKAAVIKEE-DQEFPTGSEEEDEDGEKSKSRRK 256
                            |.::| :|:|...:.:    .||:| ..:..||.|          |.||
  Fly   187 ----------------PASERVIRENQVRLRR----YIKDEMKYDLATGIE----------SSRK 221

  Fly   257 RIPPGERHLHRIIDCHICHQKFKKAIRYEEHM-KHHNDLLPFQCKVETCRKGFT-TAGGLRLHID 319
            ....|..      :|.:|.:||..|.....|| ||..||:|.|    |..:..| .|.|  ||:
  Fly   222 NAAKGPN------ECTMCDRKFVHASGLVRHMEKHALDLIPSQ----TSEQPHTIPAAG--LHV- 273

  Fly   320 HAHTELSEVHSCNVDGCGKTF--PRIRLLTFHMKKMHGI-------TKAAAPPRDYPCTEC---E 372
                    |..||  .||:.|  |::..       .||:       |...:|....|....   |
  Fly   274 --------VVKCN--SCGRIFYDPQVAF-------RHGLIHDSEHSTMRQSPMTQVPSNRADFNE 321

  Fly   373 KVFRCPMAL----------------KKHMYKHDGKELPFPCNICGKRFVINSALKDHLMRHAGIK 421
            .:....|.:                ||.|:..........|..|...|...:.|..|...|...:
  Fly   322 LLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAER 386

  Fly   422 NYVCPYCGVGKTTRQEWNTHILTH-------------TQEKKFKCHICEHASHNKQSLANH---- 469
            .:.|..|.:...|.:|.:.|..|.             |..:.|.|::||....|...|..|
  Fly   387 RFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTS 451

  Fly   470 ---IKIVHEKIKN--YACQYCGKTFGKSHACKIH-EMTHTGEKRCE---------------CKVC 513
               ...::|..|.  ..|.:|...|..:|....| |..|..:|:.|               |.:|
  Fly   452 FHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDIC 516

  Fly   514 GKKFLYPKSLTKHLKTHEKRVLRAIETYRQRQVEMGETPGEQFDNPPAPPVEGISIEPIMSRNAA 578
            ||.:.....|.:||:.|:                                    .::|.
  Fly   517 GKSYTQSSHLWQHLRFHQ------------------------------------GVKPF------ 539

  Fly   579 DELLKVCAESVATIPKDPRRVQRVDLAQLAGTAVNPIPSVSVPSWSPQVNFTKKEGKHICPGCGQ 643
                 ||.|.                                                   .|.:
  Fly   540 -----VCQEE---------------------------------------------------NCDR 548

  Fly   644 GFNNIGNMKRHYKIIHEKVKDFACRFCPKRFAKAQTLRHHEWIHTGEKPFECKTCGTHFRQETAL 708
            .|....::..|.:..|...:.:.|..|.|||........|..||.||:.:||:.||..|.:..||
  Fly   549 KFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADAL 613

  Fly   709 KRHQRTHENRPP---VISPKFYAAREELEEQERSKREAKRQADAKRREIAEAAKEQL--SSLHKL 768
            |.|||.|....|   :...|.:..|.:.::..|::..   ..||..|.:.:..|.||  ::..|.
  Fly   614 KNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHS---HLDANSRLMMQMQKFQLETAAAQKA 675

  Fly   769 ESSDRSLHSYDEYQEAAAERAAASAELQAQQFEENEVKRLAEEERRKVQEAAYEQLQLLQHQQE- 832
            :|     |:.::.....|..|:.|.......|...|            ...|..|..:...|||
  Fly   676 QS-----HNPEQQDNDVAGGASTSDVPSGSGFMSTE------------PSVAEMQYSITPEQQEE 723

  Fly   833 -----VDKAQSS-YDGYYAQKA--HADGT 853
                 :|:..:| :..:|.|..  ..||:
  Fly   724 MVCVPIDEVNNSFFMSHYMQAVPMEEDGS 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871	172/874 (20%)
		C2H2 Zn finger	334..353	CDD:275368	4/20 (20%)
		C2H2 Zn finger	368..388	CDD:275368	5/38 (13%)
		COG5048	394..729	CDD:227381	71/375 (19%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		C2H2 Zn finger	425..445	CDD:275368	5/19 (26%)
		C2H2 Zn finger	453..474	CDD:275368	6/27 (22%)
		C2H2 Zn finger	482..502	CDD:275368	6/20 (30%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		C2H2 Zn finger	638..659	CDD:275368	3/20 (15%)
		C2H2 Zn finger	667..687	CDD:275368	6/19 (32%)
		C2H2 Zn finger	695..715	CDD:275368	10/19 (53%)
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275370	8/28 (29%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	52/294 (18%)
		C2H2 Zn finger	469..490	CDD:275368	6/20 (30%)
		C2H2 Zn finger	513..564	CDD:275368	15/148 (10%)
		C2H2 Zn finger	541..561	CDD:275368	5/70 (7%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		C2H2 Zn finger	600..620	CDD:275368	10/19 (53%)
		zf-H2C2_2	612..637	CDD:463886	9/24 (38%)
		C2H2 Zn finger	628..646	CDD:275368	2/17 (12%)