Protein Alignment CG7376 and irc20

DIOPT Version :10

• Sequence 1: NP_648034.1
• Gene: CG7376 / 38715
• FlyBaseID: FBgn0035689
• Length: 1270
• Species: Drosophila melanogaster
• Sequence 2: NP_001342916.1
• Gene: irc20 / 2542902
• PomBaseID: SPAC144.05
• Length: 1375
• Species: Schizosaccharomyces pombe
• Alignment Length: 1386
• Identity: 321/1386 - (23%)
• Similarity: 524/1386 - (37%)
• Gaps: 392/1386 - (28%)

  Fly    82 VRAREIEMEVGEQVLPLFF------------KDFRGSLEFEVAQQEKEHKRPLKTYVTTKLYDAL 134
            |:..|:.:..|..:|..|.            ..:...|::.....|.|....|.  :.|.|:
pombe   133 VKGSELILSFGISILDSFLAPQDAILSSGSSSSYTALLDYTFLPSEDEEYSCLD--INTALF--- 192

  Fly   135 YEKHRQTVHVEQERSLDLPKRFQSQLRKYQQRTVSWMLGREQQ--ITQ---VPANFIVLHAIDGI 194
            |:..|:.....:..::....|..|:|..:|.|.:.||..||::  :|.   .|..:......|..
pombe   193 YDCARKLAKSLRFANVSRDPRLSSELLPFQMRVLEWMKRREEEKFLTSNDLPPLWYHCKSLFDDR 257

  Fly   195 TRVFKHKYCLQFYPFEEEIPKISLPP-----GGILADEMGLGKTVEFLAMLLMNPRPQDSYRNDY 254
            .....|.|  .:..|.:|  |..|..     |||||||||:|||:|.|.::|
pombe   258 MVYVNHVY--GYMTFSKE--KTYLLASGDIRGGILADEMGMGKTLEVLGLVL------------- 305

  Fly   255 WHQRLEEFSDEVPLKRSRISKKDEVFCICTKKHGKRVQCTKCRRWQHEMCMTISEKSDLPHLCPS 319
             |.:|       |:..:.....|:|.       ||.|:.:|
pombe   306 -HHQL-------PISLTDTCTFDQVV-------GKNVKYSK------------------------ 331

  Fly   320 CWSELVKSGERLVESGATIIVSPNAIKMQWFEEIHKHISPSLKVLLYFGLHSTFWVSPFDL-AQY 383
                            ||:|::|:.|..||..||..|: |||||..|.|:..:..:....: ...
pombe   332 ----------------ATLIITPSTILDQWLSEIDLHV-PSLKVFHYQGIRKSNGLKSAKIFLDC 379

  Fly   384 DVVLTDYTILRNEIYHTTDFKSDRQMRHQQRYMRPNSPLLMVNWWRVCLDEAQMVESSTSAAAEM 448
            |:|:|.|:.||.|:.:|.  ...|.:||::|::.|.|||:.|.|||:|:|||||||:|.|..|:|
pombe   380 DIVVTSYSDLRFELLYTE--SHSRTLRHEKRHVSPKSPLIDVCWWRICVDEAQMVETSQSNVAQM 442

  Fly   449 VRMLPAINRWAVTGT-----IDELPPLLEFVGR--PEVCRPPDAWQTVDKAFQLNYKCEPLLELL 506
            :..:|.:|.|.|:||     :|:|..|| |:.|  |.......||..:.:..::...|    :|.
pombe   443 IYRIPRVNCWTVSGTPVRSEVDDLFGLL-FLLRYSPMYLYKKQAWMQIIEKKRVREFC----DLF 502

  Fly   507 EHSLWRTCKSKVEHELGIPPQTEVVHRLELSNVESLYYREEHLKCHEQFLAAVAKHTRHNADNSS 571
            ...:.|..|..||.||.:|||..:.....||.||...|::        .|:..||......|.:
pombe   503 GSLVCRHSKQDVEEELKLPPQHRICMTTRLSVVEETNYQD--------LLSEAAKSLHFFKDRN- 558

  Fly   572 CLASISPQLLRIILKPFLRIRQTCSVP---------------------VVF-----NSNVSSTD- 609
             |.....:.:|   :..:|:||.|..|                     :||     ||..||.:
pombe   559 -LDLCDEESMR---RWLVRLRQACCHPQVGFGNKSAFGGGPMKSINDVLVFMLEQTNSTFSSLNR 619

  Fly   610 ------------YLHPQDLLARLKSNNENECKTELRT-------WASSY----NGLAAIYFIKND 651
                        |.|.:|....|...:|.....||..       :.|.|    ..|...||..:.
pombe   620 KLYSDKIIVGQIYDHIKDYNKALAIWSEVRIPVELAVKELENVIYNSKYEDHGKNLPINYFGLDH 684

  Fly   652 FPQAIKYYNLLLK----LANEY---NEQNISVDSVLQIHAIYNLLQASSLAPAEHKLTELEHK-- 707
            |.....:|.||.|    :|:.|   ..:....:..|....:...:.:..:......|.|...|
pombe   685 FIHLRVWYVLLHKIYFFIASAYFSLKNEKFENEFYLLAQDLRRKIMSDVIIKTSKHLEEFSEKFI 749

  Fly   708 -KYQAQMSRLEWKY----------LEDNTRVLESALSSYNENLEKVSELEKRFEGSTLDLLATMV 761
             |...::.||:..|          :||..|:       |.| |....|:..:|....:.|:
pombe   750 PKKLVKIPRLQKSYAKGLITGHGIIEDYNRL-------YKE-LNDQKEVLIKFRDRLIHLM---- 802

  Fly   762 NHKTSLHDAIWNKVRDDFFRQNISVERLENVNSMAGMLYFMDIWHNKLQNLKSTLIAEFEFLKGV 826
              |..|.|...:...|::         .|::|:.:.:.|.:|::...|.:..:.
pombe   803 --KLPLLDQESDPTGDEY---------EESLNAQSEISYCIDVYRQMLSDRVAA----------- 845

  Fly   827 MQQACEAIKTGVLLSMEIINFIENVTVCHLTDILDANK------DKPVKPKKHRYCRLCLI---- 881
                         :|..|..|:.:.|......::::.|      ||..:.:..:|    |:
pombe   846 -------------VSGTINTFVSHETELEKYKLIESIKKSEKSLDKQAEERDKKY----LLYFEE 893

  Fly   882 ----RDSLNQFECL--LFAKKLDEKATVTEGLENPSMEISFIKSIFAFLRSKQDFSEWKEECQSK 940
                |...:|:..|  :.::.||.....|...|..       |::..:.|......|....|| |
pombe   894 REEARPKADQYGSLINIVSRLLDASNRSTSSFETS-------KNMEEYERIDAMAKEQSRICQ-K 950

  Fly   941 LELLSCLQDLVKFQIKYWIEVEYMVKAFDELEMCKM-----RILLT----DDPEEQS--NYRILA 994
            ||     ::|...|:.|...:|| .|...|:....|     .|.|.    ||.::|.  |..|:.
pombe   951 LE-----KELSIIQLTYNSRIEY-YKQLQEISDSLMPPPVSNISLNNYVKDDEKKQKFLNSVIIK 1009

  Fly   995 CQ--LDEQLQFNQ------------YNLQTSQLNFTRLCGRLKYLKHLKEDSADKPCPICQTQDD 1045
            ..  |::::...|            .|.:.|::|   :.|.:..|:.|:|:.::....|...:..
pombe  1010 ASVILEKEISEKQDEASQTTNVAELVNQKISEMN---IPGHIHLLRELEEEKSNTQRKIAHFESR 1071

  Fly  1046 VRYV----------------------------MMVCGHFVCQHCLDSMRRKNGRAGVTKCPLCRQ 1082
            .||:                            :..|||..|..||::..:.:     :.||:|:.
pombe  1072 RRYLTNLYEHIVLKAESHQICIICRDIIKQGFITTCGHLYCSFCLEAWLKHS-----SSCPMCKT 1131

  Fly  1083 --DSPQLYY------------------------------SVRPGAHKSIIGDFSTKISSVVELVL 1115
              :....||                              :.|..::..:...|.:||.::.:.:|
pombe  1132 KLNKNNAYYIGESRDIYSRQEFVTGFNKRDERLEILDDEAYRQISNMELKESFGSKIDTISKHLL 1196

  Fly  1116 KIKGENEQEKIIVFSQWQAILIEIARALSLNGIQF-------RNKCTNKDFDDFKNPLSNVTCLL 1173
            .:|......|::|||||..:|..:.::...|||.|       :|.|..:    ||...| :..|.
pombe  1197 YLKHNELYPKVVVFSQWLDVLDVLHKSFEANGIVFIRFDGKSKNTCLKR----FKEERS-LQVLT 1256

  Fly  1174 MPLSKGSKGLNLIEATHVFLVEPILNPGDERQAIGRIHRFGQKRPTKVHRFIVNETIEENILSLI 1238
            :.....|.||.|..|||||:.||:||.|.|.|||.|:||.||.|||.|:.:||.:|:|.:||:|
pombe  1257 LHARSQSSGLTLTNATHVFMCEPLLNSGIEMQAISRVHRIGQTRPTFVYYYIVEDTVEGHILNL- 1320

  Fly  1239 TSADDTTTLSTHWDLENMTLD 1259
                   :|:.|..|:.:.||
pombe  1321 -------SLTKHEQLDKLGLD 1334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7376	NP_648034.1	DEXQc_SHPRH	160..513	CDD:350828	106/370 (29%)
		PHD_SF	281..320	CDD:473978	4/38 (11%)
		TPR	636..669	CDD:197478	11/40 (28%)
		RING_Ubox	1036..1082	CDD:473075	12/73 (16%)
		SF2_C_SNF	1104..1225	CDD:350180	48/127 (38%)
irc20	NP_001342916.1	DEXQc_SHPRH	218..509	CDD:350828	106/370 (29%)
		SMC_N	706..>1054	CDD:481474	73/415 (18%)
		RING-HC_ScPSH1-like	1086..1137	CDD:438230	9/55 (16%)
		SF2_C_SNF	1186..1308	CDD:350180	48/126 (38%)