DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prdm13 and Zfp335

DIOPT Version :9

Sequence 1:	NP_648032.1	Gene:	Prdm13 / 38713	FlyBaseID:	FBgn0035687	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001093956.2	Gene:	Zfp335 / 259270	RGDID:	628751	Length:	1336	Species:	Rattus norvegicus

Alignment Length:	468	Identity:	94/468 - (20%)
Similarity:	142/468 - (30%)	Gaps:	181/468 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IEQLLPSTSITPTSMTTSSTETTLTATTSTASPAKRMRMSNPRPGVYASQYTPKDTCSMAIPTSA 86
            :|..|.||:..|:|..|:....||....|.:|.|..            ||..|.|...:|:|...
  Rat   822 VEAELTSTARQPSSEDTTPRVVTLHVAESGSSVAAE------------SQLGPSDLQQIALPPGP 874

  Fly    87 LLGS-----TVMPTDGSRSHCQLSNGELIVSGSLLRQIKLSEDVYSFNAIFELHGGQVRVRLVRD 146
            ..|:     |..|.:|..|          .||...|:              |..|...:..:|.|
  Rat   875 FSGASYSVITAPPVEGRAS----------ASGPPYRE--------------EPPGEAAQAVVVND 915

  Fly   147 VARE---DEIVAWFGE-----ELVLLMGIPFLTPLNIQGNSRYMCHLCHLTFETPHPLKIHLALG 203
            ..:|   ..|:|..|.     ||.....|.|.:|..:...:::             ||     |.
  Rat   916 TLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKW-------------PL-----LQ 962

  Fly   204 CG---RSAMDILWMRLHYALKAAARSHTETQH--------SPIPATSSTSSASPTHSPPPQMPPR 257
            ||   |...::|             |.|:|.|        :|.||||........||||
  Rat   963 CGGPPRDGPEVL-------------SPTKTHHTGGSQGSSTPPPATSHALGLLVPHSPP------ 1008

  Fly   258 FSAFRPIAALTQSLPMVPVTTAATPLSYLPSMSMATAPLSTNPMNAAAQIEAIVS--NMGASKQG 320
                                              :.|..||...:.....||..|  .|.:.|:.
  Rat  1009 ----------------------------------SAAASSTKKFSCKVCSEAFPSRAEMESHKRA 1039

  Fly   321 HL---------CIYCGKVYSRKYGLKIHIRTHTGFKPLKCKFCLRPFGDPSNLNKHVRLHLQTHP 376
            |.         |.:..:.:..   ::.|:..|:..:|.:|..|    ...|...|.:|.|:.||.
  Rat  1040 HAGPAAFKCPDCPFSARQWPE---VRAHMAQHSSLRPHQCNQC----SFASKNKKDLRRHMLTHT 1097

  Fly   377 SSSAGVADGGASGADMDGDVDIEGETDADYQCHVCHKSFPRRRDLQRHMETRHGGHHSHSHSESR 441
            :                         :..:.||||.:.|.|...|:.|::..|.       .:.|
  Rat  1098 N-------------------------EKPFSCHVCGQRFNRNGHLKFHIQRLHS-------IDGR 1130

  Fly   442 SSSTSTSSTTTMT 454
            .:.|||:.....|
  Rat  1131 KTGTSTARAPAQT 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prdm13	NP_648032.1	COG5048	280..>380	CDD:227381	21/110 (19%)
		C2H2 Zn finger	323..343	CDD:275368	2/19 (11%)
		zf-H2C2_2	336..358	CDD:290200	5/21 (24%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		zf-C2H2	406..427	CDD:278523	8/20 (40%)
		C2H2 Zn finger	408..427	CDD:275368	8/18 (44%)
Zfp335	NP_001093956.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..222
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..398
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..442
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	961..1013		19/104 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100