DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prdm13 and Zfp521

DIOPT Version :9

Sequence 1:	NP_648032.1	Gene:	Prdm13 / 38713	FlyBaseID:	FBgn0035687	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_663467.1	Gene:	Zfp521 / 225207	MGIID:	95459	Length:	1311	Species:	Mus musculus

Alignment Length:	384	Identity:	86/384 - (22%)
Similarity:	126/384 - (32%)	Gaps:	136/384 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 GEELVLLMGIPFLTPLNIQGNSRYMCHLCHLTFETPHPLKIHLALGCGRSAMDILWMRLHYALKA 222
            ||||              :.::.:.|..|...||               |..||...::|   :.
Mouse    38 GEEL--------------EEDAVHSCDSCLQVFE---------------SLSDITEHKIH---QC 70

  Fly   223 AARSHTETQHSPI---PATSSTS--SASPTHSP---------PPQMPPRFSAFRPIAALTQSLPM 273
            ......:.:..|.   ||:|.:|  ..||:|..         .|.:|               .|.
Mouse    71 QLTDGVDVEDDPSCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLP---------------YPC 120

  Fly   274 VPVTTAATPLSY-----------LPSMSMATAPLSTNPMNAAAQIEAIVSNMGASKQGHLCIYCG 327
            .....:.:.|||           ||......:.|..:..:....|:....:    |:.| |..|.
Mouse   121 QFCDKSFSRLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGD----KKYH-CSECD 180

  Fly   328 KVYSRKYGLKIHIRTHTGFKPLKCKFCLRPFGDPSNLNKHVRLHLQTHPSSSAGVADGGASGADM 392
            ..:||...||||::|||..||.||..|.|.|...|:|:.|:::|.:.        .||..||:.|
Mouse   181 AAFSRSDHLKIHLKTHTSNKPYKCAVCRRGFLSSSSLHGHMQVHERN--------KDGSQSGSRM 237

  Fly   393 ------------------DGDVDIE------------GETDADYQCHVCHKSFPRRRDLQRHMET 427
                              |...|::            .|..|..||..||:.|.....|..|:|.
Mouse   238 EDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCMYCHELFVEETSLMNHIEQ 302

  Fly   428 RHGGH--------------------HSHSHSESRSSSTSTS-STTTMTATVTTSTSKSS 465
            .|||.                    |..||.:..|.:.|.| |..|:..|..:||:..|
Mouse   303 VHGGEKKNSCSICSESFLTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDS 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prdm13	NP_648032.1	COG5048	280..>380	CDD:227381	31/110 (28%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	336..358	CDD:290200	13/21 (62%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-C2H2	406..427	CDD:278523	7/20 (35%)
		C2H2 Zn finger	408..427	CDD:275368	6/18 (33%)
Zfp521	NP_663467.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..108		8/26 (31%)
		COG5048	<83..236	CDD:227381	45/180 (25%)
		C2H2 Zn finger	120..140	CDD:275368	3/19 (16%)
		C2H2 Zn finger	148..168	CDD:275368	2/19 (11%)
		C2H2 Zn finger	176..196	CDD:275368	8/19 (42%)
		C2H2 Zn finger	204..224	CDD:275368	7/19 (37%)
		C2H2 Zn finger	248..265	CDD:275368	2/16 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..398		2/5 (40%)
		C2H2 Zn finger	407..428	CDD:275368
		C2H2 Zn finger	439..460	CDD:275368
		C2H2 Zn finger	479..498	CDD:275368
		C2H2 Zn finger	636..656	CDD:275368
		C2H2 Zn finger	666..686	CDD:275368
		C2H2 Zn finger	696..713	CDD:275368
		C2H2 Zn finger	724..745	CDD:275368
		C2H2 Zn finger	754..774	CDD:275368
		C2H2 Zn finger	785..805	CDD:275368
		C2H2 Zn finger	811..829	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..883
		C2H2 Zn finger	888..909	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	961..981	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1136
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1258..1279	CDD:275368
		C2H2 Zn finger	1288..1307	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100