DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prdm13 and lin-13

DIOPT Version :9

Sequence 1:	NP_648032.1	Gene:	Prdm13 / 38713	FlyBaseID:	FBgn0035687	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_498678.3	Gene:	lin-13 / 176083	WormBaseID:	WBGene00003002	Length:	2248	Species:	Caenorhabditis elegans

Alignment Length:	325	Identity:	67/325 - (20%)
Similarity:	100/325 - (30%)	Gaps:	127/325 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 AAARSHTETQHSPI------------PATSSTSSASPTHSPPPQMPPRFSAFRPIAALTQSLPMV 274
            ||.||..:|..|.:            |:..::.:.:...:||.|.|||    |.:.|
Worm  1857 AAPRSSLQTNGSSMGSVTTNGGRVVRPSPPNSMNVTLRRAPPQQAPPR----RIVIA-------- 1909

  Fly   275 PVTTAATPLSYLPSMSMATAPLSTNPM-NAAA----------------QIEAIVSNMGASKQGHL 322
                             .:||.:||.: |..|                :.:..:.:|.:|.....
Worm  1910 -----------------NSAPNNTNVLRNHVAVTTKCQFKDCDKVLHSEFDRQLHSMHSSNSSWF 1957

  Fly   323 CIYCGKVYSRKYGLKIH-IRTH----------TGFKP----LKC--KFCLRP-FGDPSNLNKHVR 369
            |..||.....:..|.:| |:.|          ..||.    |||  :.|..| |..|....||:|
Worm  1958 CRQCGHSPKSEIDLFLHYIQVHLKPAYDKHQSNSFKSNVFHLKCPIRSCTSPEFQSPKAFEKHMR 2022

  Fly   370 L-------------------------HLQTHPS--SSAGVADGGASGADMDGDVDI-----EGET 402
            .                         |.|.|.|  .|.|.   .||...:.|.:.:     :..|
Worm  2023 TAHAAELPFEASCCDARFASKALCVKHDQEHASFLDSNGT---DASCCPICGSLSMWSLPKDPHT 2084

  Fly   403 DA----------DYQ--CHVCHKSFPRRRDLQRHMETRH--GGHHSHSHSESRSSSTSTSSTTTM 453
            |.          ||:  |..|.|.||  .|:.:.....|  ..|....|..:...:..|:.|.|:
Worm  2085 DCLQSHIIRHGLDYRSSCRQCLKQFP--ADVNQDQVIAHILDTHGMSMHGNTFHCNLCTTGTKTV 2147

Fly 454 453
Worm 2148 2147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prdm13	NP_648032.1	COG5048	280..>380	CDD:227381	31/161 (19%)
		C2H2 Zn finger	323..343	CDD:275368	6/20 (30%)
		zf-H2C2_2	336..358	CDD:290200	11/39 (28%)
		C2H2 Zn finger	351..371	CDD:275368	8/47 (17%)
		zf-C2H2	406..427	CDD:278523	7/22 (32%)
		C2H2 Zn finger	408..427	CDD:275368	6/18 (33%)
lin-13	NP_498678.3	C2H2 Zn finger	961..982	CDD:275368
lin-13	NP_498678.3	C2H2 Zn finger	986..1003	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100