Protein Alignment PolE2 and pole2

DIOPT Version :10

• Sequence 1: NP_647995.1
• Gene: PolE2 / 38661
• FlyBaseID: FBgn0035644
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001025641.1
• Gene: pole2 / 595029
• XenbaseID: XB-GENE-973812
• Length: 527
• Species: Xenopus tropicalis
• Alignment Length: 521
• Identity: 214/521 - (41%)
• Similarity: 317/521 - (60%)
• Gaps: 10/521 - (1%)

  Fly     8 LRKRITNTFKLCGFLIRSENSSYLAEQLLPFDAAERDKWLTVITENLQSQKLLTPHVERAALEKA 72
            |:.::|:.||:.|.|:|:|.|.||:|.|...:..|.:..:..|.:.::.|.|.:..:|::.:|.|
 Frog     6 LKSKVTSAFKMHGLLLRAEASKYLSEVLSSVNEVELEDVIDSIIDAVEKQPLSSNMIEKSTVETA 70

  Fly    73 INELNRVGLDEGETVFALIDAFTVPRFRYNQRIKKF---ELDTQPR-QLLTAPRMKSDYMQQRYA 133
            :.|.:|...:..|.:|.:|.||.:||:.||...|||   ::.|.|. .|..:.|.|::..::||.
 Frog    71 VQECSRSCDETIEHIFNIIGAFDIPRYVYNSERKKFLPLKMTTLPSPNLFGSARDKAELFRERYT 135

  Fly   134 MLLQKTLRHDLFAPAVIQDGVGAEAQAKKFKLQFAENLLA-TSAMKEAVVLGLLTQLKEGKFYVE 197
            :|.|:|.||:||.|.||  |...:....||:|:..|.||. |:.:.|.:|||::|||||||.::|
 Frog   136 ILQQRTHRHELFTPPVI--GAHPDESRSKFQLKTVETLLGNTAKVGEVIVLGMITQLKEGKIFLE 198

  Fly   198 DPTGCVQLDLTGARFHAGFFCEGCFVLAEGNYNNGVLKVDGLGFPPAEPANSSRAFFGTANTWGG 262
            ||||.||||||.|:||:|.:.|.|||||||.|.:.:..::..||||.||::::||::|..|.:||
 Frog   199 DPTGAVQLDLTNAQFHSGLYTESCFVLAEGWYEDKIFHINAFGFPPTEPSSTTRAYYGNMNFFGG 263

  Fly   263 ESAKLLKYSAGLQELERTNTETTIVFLSDVRLDLPVVMEKLRQLFVGYDSCPPQAIVLMGPFTAS 327
            .|:..:|.|..|::||..|.:...|||||:.||...|.|||..:|.||.:.||...:..|.|:::
 Frog   264 PSSTSVKTSVKLRQLEEENEDAMFVFLSDLWLDQVEVTEKLHTMFSGYSTAPPTCFIFCGNFSSA 328

  Fly   328 T--RNH-HELRHHLDALGGLAAGCEQLKKQTDLILVPSSEDPTAPNILPRAPIPECLAAGLLKAW 389
            .  :|| ..|:.....|..:......:.|.:..:.||..|||....||||.||.:.:.....:..
 Frog   329 PYGKNHIRSLKDSFKILADIICEYPHIHKSSRFVFVPGPEDPGPGFILPRPPIADHITEEFRQRV 393

  Fly   390 PRTQLATNPCRLQYCTQQIVVCRLDLMAKFCRNTLHFPEDTSQIEQHFARTIVCQGHLVPIHPIA 454
            |.:...|||||:|||||:|||.|.||:.|.|||.:.||.:|..|..||.:||:.||.|.|:.|..
 Frog   394 PFSIFTTNPCRIQYCTQEIVVFREDLVNKMCRNCVRFPNNTLDIPNHFVKTILSQGLLTPLPPFV 458

  Fly   455 MPVHWDYDPALWLYPLPDLIVMGDSCQSFSSSQHGCTVLNTGSFVKSKFAFKVYIPATRTIEDSE 519
            .||:|.||.||.|||||||:|:.|....|:.:...|..:|.|||.:|.|:||||.|:::|.|||:
 Frog   459 SPVYWAYDYALRLYPLPDLVVIADKYDPFTITNTECLTINPGSFPRSGFSFKVYYPSSKTAEDSK 523

  Fly   520 I 520
            :
 Frog   524 L 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolE2	NP_647995.1	Dpoe2NT	7..76	CDD:463494	20/67 (30%)
		DNA_pol_E_B	286..483	CDD:461142	84/199 (42%)
pole2	NP_001025641.1	Dpoe2NT	2..74	CDD:463494	20/67 (30%)
		PRK04036	12..>205	CDD:235208	73/194 (38%)
		DNA_pol_E_B	287..488	CDD:461142	84/200 (42%)