Protein Alignment PolE2 and POLE2

DIOPT Version :10

• Sequence 1: NP_647995.1
• Gene: PolE2 / 38661
• FlyBaseID: FBgn0035644
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_002683.2
• Gene: POLE2 / 5427
• HGNCID: 9178
• Length: 527
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 221/522 - (42%)
• Similarity: 318/522 - (60%)
• Gaps: 12/522 - (2%)

  Fly     8 LRKRITNTFKLCGFLIRSENSSYLAEQLLPFDAAERDKWLTVITENLQSQKLLTPHVERAALEKA 72
            ||.|..:.|||.|.|:|.|...||.|.|......|.:..|..|...::.|.|.:..:||:.:|.|
Human     6 LRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSNMIERSVVEAA 70

  Fly    73 INELNRVGLDEG-ETVFALIDAFTVPRFRYNQRIKKF---ELDTQPR-QLLTAPRMKSDYMQQRY 132
            :.|.:: .:||. |.||.:|.||.:|||.||...|||   .:...|. .|...||.|::..::||
Human    71 VQECSQ-SVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLFGTPRDKAEMFRERY 134

  Fly   133 AMLLQKTLRHDLFAPAVIQDGVGAEAQAKKFKLQFAENLL-ATSAMKEAVVLGLLTQLKEGKFYV 196
            .:|.|:|.||:||.|.||  |...:....||:|:..|.|| :|:.:.:|:|||::||||||||::
Human   135 TILHQRTHRHELFTPPVI--GSHPDESGSKFQLKTIETLLGSTTKIGDAIVLGMITQLKEGKFFL 197

  Fly   197 EDPTGCVQLDLTGARFHAGFFCEGCFVLAEGNYNNGVLKVDGLGFPPAEPANSSRAFFGTANTWG 261
            |||||.|||||:.|:||:|.:.|.|||||||.:.:.|..|:..||||.||::::||::|..|.:|
Human   198 EDPTGTVQLDLSKAQFHSGLYTEACFVLAEGWFEDQVFHVNAFGFPPTEPSSTTRAYYGNINFFG 262

  Fly   262 GESAKLLKYSAGLQELERTNTETTIVFLSDVRLDLPVVMEKLRQLFVGYDSCPPQAIVLMGPFTA 326
            |.|...:|.||.|::||..|.:...||||||.||...|:||||.:|.||...||...:|.|.|::
Human   263 GPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEVLEKLRIMFAGYSPAPPTCFILCGNFSS 327

  Fly   327 STRNHHELRHHLDALGGLA-AGCE--QLKKQTDLILVPSSEDPTAPNILPRAPIPECLAAGLLKA 388
            :....::::...|:|..|| ..||  .:.:.:..:.||..|||...:||||.|:.|.:.....:.
Human   328 APYGKNQVQALKDSLKTLADIICEYPDIHQSSRFVFVPGPEDPGFGSILPRPPLAESITNEFRQR 392

  Fly   389 WPRTQLATNPCRLQYCTQQIVVCRLDLMAKFCRNTLHFPEDTSQIEQHFARTIVCQGHLVPIHPI 453
            .|.:...|||||:|||||:|.|.|.||:.|.|||.:.||.....|..||.:||:.||||.|:...
Human   393 VPFSVFTTNPCRIQYCTQEITVFREDLVNKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLY 457

  Fly   454 AMPVHWDYDPALWLYPLPDLIVMGDSCQSFSSSQHGCTVLNTGSFVKSKFAFKVYIPATRTIEDS 518
            ..||:|.||.||.:||:|||:|:.|....|:::...|..:|.|||.:|.|:|||:.|:.:|:|||
Human   458 VCPVYWAYDYALRVYPVPDLLVIADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDS 522

  Fly   519 EI 520
            ::
Human   523 KL 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolE2	NP_647995.1	Dpoe2NT	7..76	CDD:463494	23/67 (34%)
		DNA_pol_E_B	286..483	CDD:461142	84/199 (42%)
POLE2	NP_002683.2	Dpoe2NT	2..74	CDD:463494	23/67 (34%)
		DNA_pol_E_B	287..489	CDD:461142	85/201 (42%)