Protein Alignment PolE2 and pole-2

DIOPT Version :10

• Sequence 1: NP_647995.1
• Gene: PolE2 / 38661
• FlyBaseID: FBgn0035644
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_501489.3
• Gene: pole-2 / 177673
• WormBaseID: WBGene00017237
• Length: 521
• Species: Caenorhabditis elegans
• Alignment Length: 534
• Identity: 157/534 - (29%)
• Similarity: 247/534 - (46%)
• Gaps: 40/534 - (7%)

  Fly     8 LRKRITNTFKLCGFLIRSENSSYLAEQLLPFDAAERDKWLTVITENLQSQKLLTPHVERAALEKA 72
            ||:.|..||::..|.::.|......:..|..|...|.||...:.|.|:.|.|.:..:....:...
 Worm    10 LRREIVKTFQIHAFELKKEAVKLCVKLFLDHDKETRKKWTNKMIELLKKQTLQSSLISEELIRDT 74

  Fly    73 INELNRVGLDEGETVFALIDAFTVPRFRYNQRIKKFELDTQPRQLLTAPRMKSDYMQQRYAMLLQ 137
            ..:....|..:...:..:.|||::..:.::..::|..|..:...|.......|...:||:.::.|
 Worm    75 FRQCKSKGTQDAGKLLNVFDAFSLQPYDFDADLRKMVLRKEKTSLAADSSSFSHAARQRFFIVKQ 139

  Fly   138 KTLRHDLFAPAVIQDGVGAEAQAKKFKLQFAENL-LATSAMKEAVVLGLLTQLKEGKFYVEDPTG 201
            :.:|.               |..|.||....|.| .:|..::..||||:|||.|...:::||.:|
 Worm   140 RAMRC---------------ASLKNFKFTTCEILGSSTKHLQSVVVLGMLTQQKADCYHIEDLSG 189

  Fly   202 CVQLDL-TGARFHAGFFCEGCFVLAEGNYNNGVLKVDGLGFPPAEPANSSRAFFGTANTW-GGES 264
            .|:::. ...:||...|.|....:.||.:.|.||.|:.:...|.|.|..:|....:...| ||:.
 Worm   190 SVEVEFKEDTKFHHALFHEHSIAIFEGTFENSVLTVNEVAMVPVESAEVTRKELSSNENWFGGDD 254

  Fly   265 AKLLKYSAGLQELERTNTETTIVFLSDVRLDLPVVMEKLRQLFVGYDSCPPQAIVLMGPFTASTR 329
            ....:.|..|:.......:|::||||||.||...||:.:.:|..||...||.|||..|.|.:..|
 Worm   255 KIAFRCSDRLRSALAKQEDTSLVFLSDVFLDDKKVMKAVFKLLQGYKDQPPVAIVFCGNFCSRPR 319

  Fly   330 NHHELRHHLDALGGLAAGCEQLKKQ----------TDLILVPSSEDPTAPNILPRAPIPECLAAG 384
                   ..|.:..|..|...|..|          |..|.||..:||....:|||..:|..|...
 Worm   320 -------QTDTIDLLDRGFRWLANQLTPLRKDYEKTQFIFVPGPDDPFVDTVLPRPHLPSLLFKH 377

  Fly   385 LLKAWPRTQLATNPCRLQYCTQQIVVCRLDLMAKFCRNTLHFPEDTSQIEQHFARTIVCQGHLVP 449
            :......| .|:||||:|:.:|:|||.|.||:.|.||:::: ......|...:||:::.|.||.|
 Worm   378 ISPIISCT-FASNPCRIQFASQEIVVFRSDLIKKTCRHSIN-SITVESIPSRYARSVLSQAHLCP 440

  Fly   450 IHPIAMPVHWDYDPALWLYPLPDLIVMGDSCQSFSSSQHGC--TVLNTGSFVKSKFAFKVYIPAT 512
            :.....||..|:..:|.|:|||||::..|..::|:....|.  .|.|.|||.:|.:.|.||.|..
 Worm   441 LPQHITPVLPDFSHSLSLHPLPDLLITADRFETFTEKVVGADTIVSNPGSFSRSNYTFHVYYPCQ 505

  Fly   513 RTIEDSEIP-DELE 525
            ..:|.|:|| .||:
 Worm   506 NRVEASQIPVSELD 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolE2	NP_647995.1	Dpoe2NT	7..76	CDD:463494	16/67 (24%)
		DNA_pol_E_B	286..483	CDD:461142	72/206 (35%)
pole-2	NP_501489.3	Dpoe2NT	6..78	CDD:463494	16/67 (24%)
		DNA_pol_E_B	276..475	CDD:461142	72/207 (35%)