Protein Alignment CG18586 and ACSS1

DIOPT Version :9

• Sequence 1: NP_647993.2
• Gene: CG18586 / 38659
• FlyBaseID: FBgn0035642
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_115890.2
• Gene: ACSS1 / 84532
• HGNCID: 16091
• Length: 689
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 121/598 - (20%)
• Similarity: 236/598 - (39%)
• Gaps: 113/598 - (18%)

  Fly    23 IWSGREAP--SLFSPNLSIGEI--IFGDMVN------------NPKLIAQISITE----DIVLTR 67
            :|   :.|  :::..:.|.|:|  ..|..:|            :|:.:|.|...:    ::.:|.
Human    82 VW---DTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITY 143

  Fly    68 EDLHMNAMRVASYMRNMGLGQTDIVGVMGRHTTHQSAVAYAC---------FFNGTPLHALHNAY 123
            .:|.....|:|:.::..|:.:.|.|.:....:....|...||         .|.|....:|....
Human   144 RELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRI 208

  Fly   124 EEA-C-IAKLF--GITKPRLIFCDGDEYEK-VKSATK---DLQVTIVTMRNHPRGSVRIQDVLTT 180
            .:| | :...|  |:...|::     |.:| |..|.|   .:|..:|..|...:..:...||...
Human   209 NDAKCKVVITFNQGLRGGRVV-----ELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLE 268

  Fly   181 PVMQNFQPLRLKD--GIDHTLAILSSSGTSGFPKAVTISN---------SHKIIVDYMAINNSNI 234
            ..|....|:...:  |.:..|.:|.:||::|.||.:..:.         :||::.|:..   .:|
Human   269 QEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQP---GDI 330

  Fly   235 QYTSSTLDWCSGLSMAI--------TSGVFSTTSIIADCDFDPGLFCRAIGKYRISMVLLSSSYL 291
            ....:.:.|.:|.|..:        ||.:|.:|.:..:.    |.:...:.:.:|:....:.:.:
Human   331 FGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNA----GRYWETVERLKINQFYGAPTAV 391

  Fly   292 AIF-----ANCPEFESADLSSLNYV--------------IFGGSSCSLEVQRKVRSRLSHDCLNF 337
            .:.     |...:::.:.|.:|..|              :.|.|.|:| |....::.....|:
Human   392 RLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTL-VDTWWQTETGGICI-- 453

  Fly   338 CYGLTELNSAGSVNLNFDEKPNSVGRAIRGIKIKVIDEQGEAQE-PNVVGEICFHNSQKWAGYYK 401
               ....:..|:..|     |....|...||...::||:|...| .||.|.:|.  ||.|.|..:
Human   454 ---APRPSEEGAEIL-----PAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCI--SQAWPGMAR 508

  Fly   402 N--PDETRQI----QDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYPSEIENVIAEMP 460
            .  .|..|.:    :....:..|||..|..:.||..:..|:.|::.........:|||:.||:.|
Human   509 TIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHP 573

  Fly   461 NVLEACVFGIWDPVNGDEAAASLVKKPGTQLEAQDVVEYVRKRITAKFKQ--LNGGALIVDQIVR 523
            .|.|:.|.|....:.|:.|.|.:|.|.... ::..||:.::..:..|..:  :....|:|.::.:
Human   574 AVPESAVIGYPHDIKGEAAFAFIVVKDSAG-DSDVVVQELKSMVATKIAKYAVPDEILVVKRLPK 637

  Fly   524 SGNRKTNRSAVKE 536
            :.:.|..|..:::
Human   638 TRSGKVMRRLLRK 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	119/584 (20%)
		AFD_class_I	55..530	CDD:302604	112/542 (21%)
ACSS1	NP_115890.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	17..46
		Ac_CoA_lig_AcsA	54..676	CDD:274022	121/598 (20%)
		Coenzyme A binding. /evidence=ECO:0000250	224..227		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910