DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18586 and CG17999

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	152/535 - (28%)
Similarity:	263/535 - (49%)	Gaps:	25/535 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YDDKLKIWSGREAPSLFSPNLSIGEIIFGDMVNNPKLIAQISITEDIVLTREDLHMNAMRVASYM 81
            ||...:.|.|......:.|.:::||:|...:..|...:.||..|....||...|...:.|:|...
  Fly     7 YDAASRTWFGPRGKDFYGPEMTLGEVIMRVLQINADQVMQICDTTGQELTGAQLAQQSARIAQAF 71

  Fly    82 RNMGLGQTDIVGVMGRHTTHQSAVAYACFFNGTPLHALHNAYEEACIAKLFGITKPRLIFCDGDE 146
            :.:||.:.|:||:...::|:.::|..|....|.|::.||..:.|..:..::.||:|::||||.:.
  Fly    72 KRLGLRRGDVVGISANNSTYLTSVIIAALLRGIPINPLHPEFTEETVKYMYDITEPKVIFCDVEN 136

  Fly   147 YEKVKSATKDLQ--VTIVTMRNHPRGSVRIQDVLT---TPVMQNFQPLRLKDGIDHTLAILSSSG 206
            |..:|:....||  ..|..:.....|.:.|.::|.   :.....:.|.....| |||..|:.|||
  Fly   137 YHIIKTVNGKLQNPAKIYLVNGKLEGVLDISEMLNDEDSITAAAYVPCPKLHG-DHTAFIVCSSG 200

  Fly   207 TSGFPKAVTISNSHKIIV----DYMAINNSNIQYTSSTLDWCSGLSMAITSGVFSTTSIIADCDF 267
            |:|.||.||  .||:.::    :.......::..:.|.|.|.||..:.:.|.:.....||.:..:
  Fly   201 TTGMPKGVT--RSHRSLLCNCKNPNTYTRDSVLLSFSPLYWISGTIILLASLLNGCRRIITNRPY 263

  Fly   268 DPGLFCRAIGKYRISMVLLSSSYLAIF----ANCPEFESADLSSLNYVIFGGSSCSLEVQRKVRS 328
            ......:.:.:::::.:.|:|..:|:.    ::..|.: |.|.|:..:|..||.....|.|::..
  Fly   264 SVEYLLQLVARHKVTFLFLASHQIALLSKHDSDVMELK-AQLQSIRVLIGAGSKVCKAVCRRMYE 327

  Fly   329 RLSHDCLNFCYGLTELNSAGSVNLNFDEKPNSVGRAIRGIKIKVIDEQGEAQEPNVVGEICFHNS 393
            .:.:......|||:|:   |.::.|........|:.:|.::::|:|:.......|.||.|.....
  Fly   328 LIGNQRFVVGYGLSEM---GGLSKNVGGPVGCEGKVMRNVELRVLDKLKMPLGINEVGIIYARLR 389

  Fly   394 QKWAGYYKNPDETRQIQDSEN-WIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYPSEIENVIA 457
            .||||||:||:.||:...|:. |..|||:||:|.:|||::..|..|:.|:.|...||.:||..|.
  Fly   390 FKWAGYYRNPEATRRALSSDGMWFRTGDIGYLDSEGYLYIQTRDTDVFKFNNFQIYPEQIEEFIL 454

  Fly   458 EMPNVLEACVFGIWDPVNGDEAAASLV--KKP-GTQLEAQDVVEYVRKRITAKFKQLNGGALIVD 519
            .:|.|.|||||||.|.|:.:..|.::|  |.| |.:|.|..:...|...::..: .:.||...:|
  Fly   455 RLPGVSEACVFGIPDAVSTNLTACAVVRTKSPEGERLTADHIRNIVEHHLSGAY-HIRGGVYFID 518

  Fly   520 QIVRSGNRKTNRSAV 534
            .:.::.|.|..|..|
  Fly   519 SLPKTPNDKLQRRKV 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	148/517 (29%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	141/491 (29%)
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	148/517 (29%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	142/498 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471337
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	8	7.860