DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18586 and DIP2C

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_011517730.1	Gene:	DIP2C / 22982	HGNCID:	29150	Length:	1626	Species:	Homo sapiens

Alignment Length:	698	Identity:	132/698 - (18%)
Similarity:	244/698 - (34%)	Gaps:	204/698 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVKQKLLNA--------MCTYDDKLKIWSGREAPSLFSPNLSIGEIIFGDMVNNPKLIAQIS--- 58
            |.||..|..        ||.:.....:...|:.    .|.:....::.|::|:. |.|||.|
Human   957 ETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQK----QPEIGPASVMVGNLVSG-KRIAQASGRD 1016

  Fly    59 -------------------------ITEDIV--------------LTREDLHMNAMRVASYMRNM 84
                                     .|.|.:              ||...||..|.::|..:...
Human  1017 LGQIEDNDQARKFLFLSEVLQWRAQTTPDHILYTLLNCRGAIANSLTCVQLHKRAEKIAVMLMER 1081

  Fly    85 G-LGQTDIVGVMGRHTTHQSAVAYACFFNG------TPLHALHNAYEEACIAKLFGITKPRLIFC 142
            | |...|.|.::........|..|.|.:.|      .|.|..:.|.....:..:..:::
Human  1082 GHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSR------ 1140

  Fly   143 DGDEYEKVKSATKDLQVTIVTMRNHPRGSVRIQDVLTTPVMQNFQPLRLKDGID-------HTLA 200
                    .:.....|:....:|:  |.:....||.|.|::.:...|..|....       .|||
Human  1141 --------SACLMTTQLICKLLRS--REAAAAVDVRTWPLILDTDDLPKKRPAQICKPCNPDTLA 1195

  Fly   201 IL---------------SSSGTSGFPKAVTI------SNSHKIIVD-YMAINNSNIQYTSSTLDW 243
            .|               |.:.||.|.:::.:      |....|.:| |..:         ..:.|
Human  1196 YLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGL---------GFVLW 1251

  Fly   244 CSGLSMAITSGVFSTTSIIADCDFDPGLFCRAIGKYRISMVLLSSSYLAIFANCPEFESADLSSL 308
            |   ..::.||..|.....::.:.:|.|:..|:.:|::.....|.|.:.:.......::..|.:.
Human  1252 C---LCSVYSGHQSILIPPSELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKAR 1313

  Fly   309 NYVIFGGSSCSLEVQRKVR-------SRLSHD-------------C---LNFC------YGLTEL 344
            ...:....:|.:..:.:.|       |:|..|             |   |..|      :.|.|.
Human  1314 GLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQPHRLWTLAEQ 1378

  Fly   345 NSAG----------------SVNLNFDEKPNSV-----GRAIRGIKIKVIDEQGEAQEP---NVV 385
            .::|                .|.|.....|:|:     |:.:.|::|.:.:.  |.:.|   :.:
Human  1379 GTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANP--ETKGPLGDSHL 1441

  Fly   386 GEICFHNSQKWAGYYK-NPDETRQ---------IQDSEN-WIHTGDLGYV------DKDG----Y 429
            |||..|::...:||:. ..||:.|         ..|::. |..||.||::      |.:|    .
Human  1442 GEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTIWARTGYLGFLRRTELTDANGERHDA 1506

  Fly   430 LFVIDRLKDMLKYQNIMYYPSEIE-NVIAEMPNVLEACVFGIWDPVNGDEAAASLVKKPGTQLEA 493
            |:|:..|.:.::.:.:.|:|.:|| :||....:|.|..|| .|     ......:|:..|::.||
Human  1507 LYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVF-TW-----TNLLVVVVELDGSEQEA 1565

  Fly   494 QDVVEYVRKRITAKFKQLNGGALIVD-QIVRSGNR-KTNRSAVKEHFL 539
            .|:|..|...:..:...:.|..::|| .::...:| :..|..:::.||
Human  1566 LDLVPLVTNVVLEEHYLIVGVVVVVDIGVIPINSRGEKQRMHLRDGFL 1613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	125/660 (19%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	117/629 (19%)
DIP2C	XP_011517730.1	DMAP_binding	<32..180	CDD:283995
		CaiC	377..968	CDD:223395	4/10 (40%)
		Dip2	401..965	CDD:213273	4/7 (57%)
		AMP-binding	1036..1520	CDD:278902	92/513 (18%)
		AFD_class_I	1053..1615	CDD:302604	115/597 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900