DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18586 and ACSM2A

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001295101.1	Gene:	ACSM2A / 123876	HGNCID:	32017	Length:	577	Species:	Homo sapiens

Alignment Length:	538	Identity:	122/538 - (22%)
Similarity:	207/538 - (38%)	Gaps:	85/538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 WSGREAPSLFSPNLSIGEII--FGDMVNNPKLIAQISI------TEDIVLTREDLHMNAMRVASY 80
            |..:|.|:.|:   ...:::  :.||....|.:...::      .::::....:|..|:.:.|:.
Human    35 WGHQEVPAKFN---FASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANV 96

  Fly    81 MRN-MGLGQTDIVGVMGRHTTHQSAVAYAC------FFNGT-------PLHALHNAYEEACIAKL 131
            :.. .||.:.|.|.|:.........|...|      |..||       .|:.|..:..:|.:|
Human    97 LSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVA-- 159

  Fly   132 FGITKPRLIFCDGD----EYEKVKSATKDLQVTIVTMRNHPRGSVRIQDVLTTPVMQNFQPLRLK 192
                        ||    |.:.|.|....|::.::.......|.:..:.:|......:.   .::
Human   160 ------------GDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHH---CVE 209

  Fly   193 DGIDHTLAILSSSGTSGFPKAVTISNSH-----KIIVDYMAINNSNIQYTSSTLDWCSGLSMAIT 252
            .|.....||..:|||||.||....|.|.     |:...:..:..|:|.:|.|...|...:..::.
Human   210 TGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLM 274

  Fly   253 S----GVFSTTSIIADCDFDPGLFCRAIGKYRI-SMVLLSSSYLAIFANCPEFESADLSS----- 307
            .    |..:...::.  .|||.:..:.:..|.| ||:.....|..:.       ..||||
Human   275 EPWALGACTFVHLLP--KFDPLVILKTLSSYPIKSMMGAPIVYRMLL-------QQDLSSYKFPH 330

  Fly   308 LNYVIFGGSSCSLEVQRKVRSRLSHDCLNFCYGLTELNSAGSVNLNFDEKPNSVGRAIRGIKIKV 372
            |...:..|.|...|.....|::...| :...||.||......|:.....||..:|.|.....:::
Human   331 LQNCVTVGESLLPETLENWRAQTGLD-IRESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQI 394

  Fly   373 IDEQGEAQEPNVVGEICFHNSQ-----KWAGYYKNPDETRQIQDSENWIHTGDLGYVDKDGYLFV 432
            ||::|....|...|:|......     .::||..|||:|......:.|: .||.|..|:|||...
Human   395 IDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWL-LGDRGIKDEDGYFQF 458

  Fly   433 IDRLKDMLKYQNIMYYPSEIENVIAEMPNVLEACVFGIWDPVNGDEAAASLVKKPGTQLEAQDVV 497
            :.|..|::........|||:||.:.|.|.|:|..|....|||.|:...|.:|.  .:|..:.|..
Human   459 MGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVVL--ASQFLSHDPE 521

  Fly   498 EYVR------KRITAKFK 509
            :..:      |.:||.:|
Human   522 QLTKELQQHVKSVTAPYK 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	118/527 (22%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	115/505 (23%)
ACSM2A	NP_001295101.1	AFD_class_I	40..568	CDD:388389	120/533 (23%)
		Coenzyme A binding. /evidence=ECO:0000269\|PubMed:19345228	469..471		0/1 (0%)
		Coenzyme A binding. /evidence=ECO:0000269\|PubMed:19345228	540..542		122/538 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920