DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and WEE1

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_003381.1	Gene:	WEE1 / 7465	HGNCID:	12761	Length:	646	Species:	Homo sapiens

Alignment Length:	378	Identity:	113/378 - (29%)
Similarity:	170/378 - (44%)	Gaps:	48/378 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NSNRFRPPKYKTRGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSD----SSTLPSSPV 86
            |.|.|.|           |:..|:.|   |.|........:.....|...||    ..|.|:..:
Human   234 NINPFTP-----------DSLLLHSS---GQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRI 284

  Fly    87 QAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYRAERLEEVR 151
            ....|.:. |.:...|..|.|:|.|.||.||:...|.||.:||:|.||:...|.......|.||.
Human   285 TITESNMK-SRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVY 348

  Fly   152 RYEEFSGHENCIRFIRAWEQYDRLYMQMELCR-ESLEQYLLRCQRI----PEERIWHILLDLLRG 211
            .:.....|.:.:|:..||.:.|.:.:|.|.|. .||...:....||    .|..:..:||.:.||
Human   349 AHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRG 413

  Fly   212 LKSLHDRNLIHLDIKLDNVLI------------GEDDETC------KLADFGLVIDVDRANSHHA 258
            |:.:|..:|:|:|||..|:.|            |::|:..      |:.|.|   .|.|.:|...
Human   414 LRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG---HVTRISSPQV 475

  Fly   259 TEGDSRYMAPEILQGHFS--KAADIFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKIS 321
            .|||||::|.|:||.:::  ..||||:|.:.::..|....||.||..|||:|.|.|| .....:|
Human   476 EEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLP-RIPQVLS 539

  Fly   322 LELQSVIKSMMKPDPAQRPTAEQLLSHPKLQYLQKKRKSLMNFSMLSRSFRRS 374
            .|...::|.|:.|||.:||:|..|:.|..|....:|....:...:.:..|:.|
Human   540 QEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNS 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	92/273 (34%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	92/271 (34%)
WEE1	NP_003381.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..181
		PTKc_Wee1a	293..568	CDD:271040	94/278 (34%)
		Pkinase	299..569	CDD:278497	93/273 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820