DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myt1 and Pkmyt1

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_006524373.1	Gene:	Pkmyt1 / 268930	MGIID:	2137630	Length:	539	Species:	Mus musculus

Alignment Length:	483	Identity:	174/483 - (36%)
Similarity:	245/483 - (50%)	Gaps:	75/483 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRFRPPKYKTRGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSDSSTLPS---SPVQAE 89
            :|..||:...:|.:.|  :.|...::.|.......:::..       |..|..|.|   .|.:.|
Mouse    88 SRSLPPRPPAKGCIPV--SRLFPPRTPGWHQPQPRRVSFL-------CETSEPLQSPGYDPSRPE 143

  Fly    90 LSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYRAERLEEVRRYE 154
                  |.|:|.|:||::||.||:||||:||.:.||:|||||.....|||.:.|..:|.||..:|
Mouse   144 ------SFFQQNFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRYMSPFRGPKDRTRKLAEVGGHE 202

  Fly   155 EFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRCQ----RIPEERIWHILLDLLRGLKSL 215
            :...|.:|:|..||||:...||:|.|||..||:|:   |:    .:||.::|..|.|:|..|..|
Mouse   203 KVGQHPHCVRLERAWEEGGILYLQTELCGPSLQQH---CEAWGASLPEAQVWGYLRDILLALDHL 264

  Fly   216 HDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDVDRANSHHATEGDSRYMAPEILQGHFSKAAD 280
            |.:.|:|||:|..|:.:|.... |||.||||::::..|.:..|.|||.||||||:|||.:..|||
Mouse   265 HSQGLVHLDVKPANIFLGPRGR-CKLGDFGLLVELGSAGAGEAQEGDPRYMAPELLQGSYGTAAD 328

  Fly   281 IFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKISLELQSVIKSMMKPDPAQRPTAEQL 345
            :||||:.:||:||.|:||..|..|.:||.|.||.||...:|.||:||:..|::|||..|.|||.|
Mouse   329 VFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLAMMLEPDPQLRATAEAL 393

  Fly   346 LSHPKLQYLQKKRKSL---MNFSMLSRSFRRSRRAVWGRMCNWKTAAFRYLLYFLEVLH-LCKPI 406
            |:.|.|:  |.:..::   |....|||.:     |:|        .|...||.:|  .| |..|.
Mouse   394 LALPMLR--QPRPWNVLWYMAAEALSRGW-----ALW--------QALVTLLCWL--WHGLVHPA 441

  Fly   407 TASQPNINIVPSSPSSKGVPLVPQVEFQLVGSTPIANRDCYASDFLSGEDPLDLSNQGSPNVI-- 469
            :..||           .|.|..|.      ||.|.:  ....|...|..|...:....||..:
Mouse   442 SWLQP-----------PGPPATPP------GSPPCS--PLLDSTLSSSWDNDSIGPSLSPETVLS 487

  Fly   470 -----NSTPLNTNQGKSRLDLLKNNVDS 492
                 .|||......:..|||  .:|||
Mouse   488 RITRRTSTPRGRYIPRDALDL--TDVDS 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	121/252 (48%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	120/250 (48%)
Pkmyt1	XP_006524373.1	PKc_Myt1	148..397	CDD:270952	121/252 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850384
Domainoid	1	1.000	239	1.000	Domainoid score	I2282
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003337
OrthoInspector	1	1.000	-	-		oto93567
orthoMCL	1	0.900	-	-		OOG6_104974
Panther	1	1.100	-	-	LDO	PTHR11042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	1	1.000	-	-		X4326
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.740