DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myt1 and pkmyt1

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_012825559.1	Gene:	pkmyt1 / 100145798	XenbaseID:	XB-GENE-969853	Length:	603	Species:	Xenopus tropicalis

Alignment Length:	558	Identity:	185/558 - (33%)
Similarity:	281/558 - (50%)	Gaps:	114/558 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PPKYKTRGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSDSSTLPSSPV--QAELSTLS 94
            ||:...:..:.:.....|:.:|.      |.....::|||    |..:..|:|.:  |::..|.
Frog    99 PPRPPVKSALPISRLFPNKQRSW------SQPRPQSVSFR----SPQNNPPASELYDQSKGETF- 152

  Fly    95 LSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYRAERLEEVRRYEEFSGH 159
               |:|||..:.|||.||||||::|:...||..||||.|...||||..|..:|:|||::|....|
Frog   153 ---FKQCFRSICKLGRGSFGEVYKVQSLEDGCFYAVKRSVSPFRGESDRQRKLQEVRKHERVGVH 214

  Fly   160 ENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRCQ-RIPEERIWHILLDLLRGLKSLHDRNLIHL 223
            .||:||:||||:...||:|.|||..||:|:..... .:|..:||:|..|||.|||.||||||:||
Frog   215 PNCLRFVRAWEEKRLLYLQTELCAGSLQQHSEEFSGPLPPRKIWNITCDLLHGLKHLHDRNLLHL 279

  Fly   224 DIKLDNVLIGEDDETCKLADFGLVIDVD-RANSHHATEGDSRYMAPEILQGHFSKAADIFSLGIA 287
            |||..||.|.... .|||.||||::::| ...|..|.|||.||||||:|.|.||||||:||||::
Frog   280 DIKPANVFISFSG-VCKLGDFGLMVELDGTEGSGEAQEGDPRYMAPELLDGIFSKAADVFSLGMS 343

  Fly   288 MLELACYMDLPSNGPLWHELRHGILPEEFINKISLELQSVIKSMMKPDPAQRPTAEQLLSHPKLQ 352
            :||:||.|:||.:|..|.:||.|.||.||.:.:..:...|:.:|::||..:|.|.:.|||.|.::
Frog   344 LLEVACNMELPKSGDGWQQLRQGRLPTEFTSDLPPDFLKVLAAMLEPDYRRRATVDWLLSLPAIR 408

  Fly   353 YLQKKRKSLMNFSMLSRSFRRSRRAVWGRMCNWKTAAFRYLLYFLEV------------LHLCKP 405
            ..::.|       |::.:..|:...:        ...::::::.:.:            ||.|
Frog   409 NAERWR-------MVTLAQERTLGKI--------ITVYQFIVWLVSIVFQGLNRPVVGFLHYC-- 456

  Fly   406 ITASQPNINIVPSSPSSKGVPLVPQVEFQLVGSTPIANRDCYASDF---LSGED-------PL-- 458
                  .:..:|.||     |..|         :|......::||:   ..|:|       ||
Frog   457 ------GLRALPRSP-----PCSP---------SPNLGESSFSSDWDDESLGDDVFEVPPSPLAA 501

  Fly   459 ---------DLSNQGSPNVIN-------STPLNTN-----QGKSRLDLLKN----NVDSMGRYVH 498
                     :|..:.||::::       |||.|.:     :.:|.|.|..|    :.:|.|....
Frog   502 HRNFTYHGQELIGRHSPDLLSRPSLGSTSTPRNLSPEFSMRKRSALPLTPNVSRISQESSGSVKS 566

  Fly   499 VHDFESPCSALSSAKVLDT----SSFRRKKLFVLEYDD 532
            .    ||.::.||:..:|.    |||..:.|..: :||
Frog   567 T----SPSTSHSSSGFVDAEVQRSSFLPRNLLSM-FDD 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	128/250 (51%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	126/248 (51%)
pkmyt1	XP_012825559.1	PKc_Myt1	155..405	CDD:270952	128/250 (51%)
pkmyt1	XP_012825559.1	Pkinase	162..405	CDD:278497	125/243 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	242	1.000	Domainoid score	I2197
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003337
OrthoInspector	1	1.000	-	-		oto103801
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4326
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010