Protein Alignment Usp47 and USP34

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: NP_055524.3
• Gene: USP34 / 9736
• HGNCID: 20066
• Length: 3546
• Species: Homo sapiens
• Alignment Length: 807
• Identity: 171/807 - (21%)
• Similarity: 293/807 - (36%)
• Gaps: 206/807 - (25%)

  Fly   380 ETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQK 444
            :..||.|        :|||.|...||||.|.:|.|:|.||.|.|::..::..|.:.|....:|||
Human  1886 DVRAECR--------FVGLTNLGATCYLASTIQQLYMIPEARQAVFTAKYSEDMKHKTTLLELQK 1942

  Fly   445 LFLNLQTSPKAAVETTDLTRSFGWDS--TEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLY 507
            :|..|..|...|.......:::..|.  ....:|.|:.|....:...:|......|  |.:.:|:
Human  1943 MFTYLMESECKAYNPRPFCKTYTMDKQPLNTGEQKDMTEFFTDLITKIEEMSPELK--NTVKSLF 2005

  Fly   508 EGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEK 572
            .|.:.:.|..|:|.......:.|..:...|...  .:.|.|::|.    ...:||:|:|.|.|..
Human  2006 GGVITNNVVSLDCEHVSQTAEEFYTVRCQVADM--KNIYESLDEV----TIKDTLEGDNMYTCSH 2064

  Fly   573 CKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQN 637
            |.||..|.|...||..|.||:.:..|:.|:..||.:.|:|...:||..|::..:
Human  2065 CGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLDMTPY----------- 2118

  Fly   638 SQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPY 702
                              .||..:..               ::..||....|..||.::.    |
Human  2119 ------------------TEDFLMGK---------------SERKEGFKEVSDHSKDSES----Y 2146

  Fly   703 LYELFAIMIHSGSASGGHYYAYIKD------FDNNEWFCFNDQNVTSITQEDI-QRSFGGP---- 756
            .|:|..:.:|:|:|.|||||::|:|      :.||:|:.|||..|.......: ...|||.
Human  2147 EYDLIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNKWYLFNDAEVKPFDSAQLASECFGGEMTTK 2211

  Fly   757 -----NGSYYSSAYTSSTNAYMLMYRQVDAKR-----------NELVAKVADFPEHIKTLLPKLH 805
                 ...:...::..:.:||||.|::::.:.           :||:..:  :.::::.|..| :
Human  2212 TYDSVTDKFMDFSFEKTHSAYMLFYKRMEPEEENGREYKFDVSSELLEWI--WHDNMQFLQDK-N 2273

  Fly   806 SEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKMKITRVYVSQSFNINLVLMSAYEMLNV 870
            ..|.|....:.:..:.....|||   |:..    ||...|::..:|.::|
Human  2274 IFEHTYFGFMWQLCSCIPSTLPD---PKAV----SLMTAKLSTSFVLETF--------------- 2316

  Fly   871 EQFAPLSRCRLVAYNSSMDTIIQSLESCTDPALTELRAAQNYSLDFLLEYRAED----QEFEVYP 931
                        .::....|::|.:|     .||:.......:.::.|:..|:|    .:..:..
Human  2317 ------------IHSKEKPTMLQWIE-----LLTKQFNNSQAACEWFLDRMADDDWWPMQILIKC 2364

  Fly   932 PNGITWYVFK----------------VDLSTMAMDGPFLVYSAAREREASDVLRRSIALRLHISE 980
            ||.|...:|:                :.|.....||     |...:....|:..||...|.   .
Human  2365 PNQIVRQMFQRLCIHVIQRLRPVHAHLYLQPGMEDG-----SDDMDTSVEDIGGRSCVTRF---V 2421

  Fly   981 QQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMA-----NTQF-------KSITYFYLNVPNTD 1033
            :..||.......|     :..|.| |....|...|     .:||       .::.:||:.....:
Human  2422 RTLLLIMEHGVKP-----HSKHLT-EYFAFLYEFAKMGEEESQFLLSLQAISTMVHFYMGTKGPE 2480

  Fly  1034 AATLEMLGVPTVESVECASGGDVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVEPMSQPSPSHGH 1098
            ...:|:|.....|..|  ...|::..|.                 .:|:...:|.|.........
Human  2481 NPQVEVLSEEEGEEEE--EEEDILSLAE-----------------EKYRPAALEKMIALVALLVE 2526

  Fly  1099 ESNSEDSSLSDGDRTLVETDNMAHRGG 1125
            :|.||      ...||.:||..|..||
Human  2527 QSRSE------RHLTLSQTDMAALTGG 2547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066
		peptidase_C19C	394..780	CDD:239124	102/403 (25%)
		USP47_C	1300..1534	CDD:466158
USP34	NP_055524.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..535
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	550..679
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1459..1478
		peptidase_C19C	1892..2241	CDD:239124	103/412 (25%)
		DUF3517	2359..2692	CDD:463438	43/228 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3331..3443