Protein Alignment Usp47 and Usp47

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: NP_001390423.1
• Gene: Usp47 / 74996
• MGIID: 1922246
• Length: 1396
• Species: Mus musculus
• Alignment Length: 1527
• Identity: 485/1527 - (31%)
• Similarity: 709/1527 - (46%)
• Gaps: 307/1527 - (20%)

  Fly   161 DSLAKTSISSESSPEK---------TSKIKTTAAKISKPGSEKAPRASPEECPELSTEINSKNTS 216
            |.:.|..:..|::.|:         |:..||.:.:|                        :.|..
Mouse    25 DEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVSERI------------------------TLNLP 65

  Fly   217 SESPVAKKTAKVTSK-----PTLELLSPIKPSSPIKELDCEPVDTLSKQQLSEQLQLYPQGRNL- 275
            :.:||.|....|.:|     .|.:|..    .:.:...|..|:|..|.:.|.: ....|..:|.
Mouse    66 ASTPVRKLFEDVANKVGYINGTFDLTR----ENGVTTADMAPLDHTSDKSLLD-ANFEPGKKNFL 125

  Fly   276 -ISPVDDAPSDLFISDAEQLSDDDLALGASASPTMLGPGYDYGAPTGDSDVEGVTGVTDPSTIGT 339
             ::..|..|..:.:.|:..:.|       |.....:||     .|.
Mouse   126 HLTDKDGEPPQMLLEDSNNVDD-------SVHDRFIGP-----LPR------------------- 159

  Fly   340 DDGTYPALSNFYRRKYGGDELRAWQRVNTTGADFVSSATTETEAEARQASLGPRGYVGLVNQAMT 404
             :|:..:.:::..:.|.                 .||...::|.          |||||||||||
Mouse   160 -EGSVASTNDYVSQNYS-----------------YSSILNKSET----------GYVGLVNQAMT 196

  Fly   405 CYLNSLLQALFMTPEFRNALYRWEFDNDNE--AKNIPYQLQKLFLNLQTSPKAAVETTDLTRSFG 467
            ||||||||.||||||||||||:|||::..|  ..:||||||:||:.||||.|.|:||||:|||||
Mouse   197 CYLNSLLQTLFMTPEFRNALYKWEFEDSEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFG 261

  Fly   468 WDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLD 532
            |||:|||||||:||||||||||||.|:|.|:||:||:.||:||:.|||:||||..|..|.||:||
Mouse   262 WDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLD 326

  Fly   533 IPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLK 597
            |||.:||:|||.|:.|:||||.||:|||.|||.|||.||:|||||||.|||.|..|||:|||.||
Mouse   327 IPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLK 391

  Fly   598 RFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLS 662
            ||||||.||||||||||::||:.|:::|||:.......|..         |..|||:..|.
Mouse   392 RFDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTE---------SCTDSGAENEG---- 443

  Fly   663 SGVVTTASSSQHENDLNDE---DEGI--DMSSSTSKSAKQG----------------------SG 700
                 :..|.|..||.:.:   ||||  :.||.:.|.:|.|                      ..
Mouse   444 -----SCHSDQMSNDFSTDDAVDEGICLESSSGSEKISKPGLEKVEMAETDQRKDPIQFQLGEPN 503

  Fly   701 PYLYELFAIMIHSGSASGGHYYAYIKDFDNNEWFCFNDQNVTSITQEDIQRSFGGPNGS--YYSS 763
            ..:||||::|:|||||:||||||.||.|.:::|:.||||:|:.||||||:::.||.:||  ||||
Mouse   504 SLMYELFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSS 568

  Fly   764 AYTSSTNAYMLMYRQVDAKRNELVAKVADFPEHIKTLLPKLH--SEEETRVSRLGRHITVTDLAL 826
            |:.||||||||:||..|..||....:|.::|||||.|:.|..  .|:|.|...:.|:..
Mouse   569 AFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTC------ 627

  Fly   827 PDLYKPRVYFYNPSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFAPLSRCRLVAYNSSMDTI 891
                |.:::..:|..:.|...::.|.:...:...:..||:|:::|...||..||||.|:...|.:
Mouse   628 ----KIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVKYDEFHDYL 688

  Fly   892 IQSLESCTDPALTELRAA--QNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFL 954
            .:|.|...|..:..|...  ..|..|.|||.|..||.|:.|.|..:...|..|||....:..|..
Mouse   689 ERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQIFQSYKPGEVMVKVHVVDLKAETVAAPVT 753

  Fly   955 VYSAAREREASDVLRRSIALRLHISEQQFLLATVRA-------TVP-------------KAFVSY 999
            |  .|...:.....::.|:...|:......:...|.       ::|             |.||..
Mouse   754 V--RAYLNQTVTEFKQLISKATHLPADSMRIVLERCYNDLRLLSMPSKTLKAEGFFRSNKVFVES 816

  Fly  1000 D---PHPTPEALQHLQNMANTQFKSITYFYLNVP---------------------NTD------- 1033
            .   .|.......||..:.:....:|..|.| :|                     |.|
Mouse   817 SETVDHQAAFTDSHLWKLLDRHANTIRLFVL-LPEQSPGSYSKRTAYQKAGGDSGNVDDDCERVK 880

  Fly  1034 --AATLEMLGVPTVESVECASG---------GDVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVE 1087
              |..|:.:.....||.|....         ||..|::          .|:...|:...:..|.|
Mouse   881 GPAGNLKSVDAILEESTEKLKSLSLQQQQQDGDNGDSS----------KSTETSDFENIESPLNE 935

  Fly  1088 PMSQPSPSH----GHESNSEDSSLSDGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAAS 1148
            ..|..|..:    .|...|:..:....:|:..:.:|.......||.:.|:|||..
Mouse   936 RGSSTSVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSD---------- 990

  Fly  1149 HDAMMRVHAYCNGNGS-YAAADVVDPLLLPTSTNHFFYATKVECVDVVGTGSSSGHQSDEEAQLR 1212
                    ..||.:.: ...|:.:|...:.:|........|.|..|.....|.:..:.||..:.|
Mouse   991 --------TLCNADSAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSR 1047

  Fly  1213 ----------KPTRA-------YKLL---VGTHMRMGAFKKHIEQLIQVPAAHFKLQRKHDNNL- 1256
                      .|..|       :|.|   |...:.:.|||:|:|..:.|.::|||:.|.:.:|.
Mouse  1048 GDMQYMYFKADPYTADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYTSNQE 1112

  Fly  1257 --SNNQNNSLVHLIEGETLTVELGKTLEPDEFKAKIHFLRLADIDNETSKLPCVCEWVYNANTTA 1319
              :...|.:|....:...:|:.||:.|:..|::.|:..|    :.||......:.:.|:....|.
Mouse  1113 FETVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVCQL----LVNEQEPCKFLLDAVFAKGMTV 1173

  Fly  1320 EQAKKELVAKLHR---IDAKYATLSVQNCRIWLKGGRIPIKILSDDETLYCDMRSSIAAEFIVQE 1381
            .|:|:||:.:|..   :|     ||:...|:..|..:.|..:..|......|:..|...| :..|
Mouse  1174 RQSKEELIPQLREQCGLD-----LSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWE-VFLE 1232

  Fly  1382 CEEEVDPQPKDDSLTLFVRRWCPAKLEFGKFQEITLDQDS--EIRLSLSQISDIPIDKLSYMKLN 1444
            ..:.|:.......|.:..|||.||:::...|||:.|:.:|  |:|..||:||.||::.:.:.|..
Mouse  1233 VLDGVEKMKSMSQLAILTRRWRPAEMKLDPFQELVLESNSVDELREKLSEISGIPLEDIEFAKGR 1297

  Fly  1445 SNFPCTSISALSVNESSSWYSVPTTLDKYPLNSTQTGNIYLYKDRTVPARELTLEERRLMNAREK 1509
            ..||| .||.|.:::...|....:||:.:||.....|.:..|:|||....|||.|:|..:..:|.
Mouse  1298 GTFPC-DISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDRTEEVMELTDEQRNELMKKES 1361

  Fly  1510 ARLDRVGCVSTTRYAQRRERALKIYLD-SPEK 1540
            :||.:.|  ....|:.|:|:||||||| :|.|
Mouse  1362 SRLQKTG--HRVTYSPRKEKALKIYLDGAPNK 1391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066	16/101 (16%)
		peptidase_C19C	394..780	CDD:239124	241/416 (58%)
		USP47_C	1300..1534	CDD:466158	72/238 (30%)
Usp47	NP_001390423.1	peptidase_C19C	186..586	CDD:239124	209/428 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..452		19/25 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	855..883		7/43 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	900..991		17/103 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1005..1045		5/40 (13%)
		USP47_C	1145..1384	CDD:466158	70/243 (29%)