Protein Alignment Usp47 and usp40

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: XP_001921353.3
• Gene: usp40 / 402834
• ZFINID: ZDB-GENE-060518-5
• Length: 1263
• Species: Danio rerio
• Alignment Length: 1420
• Identity: 308/1420 - (21%)
• Similarity: 473/1420 - (33%)
• Gaps: 473/1420 - (33%)

  Fly   392 PRGYV---GLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDN----------DNEAKNIPYQLQ 443
            |||.:   |:.||..|||||||:|.|..|||||..|:....|.          :.:.:.||.:||
Zfish    31 PRGKIKLCGIKNQGGTCYLNSLIQTLLFTPEFREELFHLGPDELGCLADKDKPEAKVRVIPLELQ 95

  Fly   444 KLFLNLQTSPKAAVETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYE 508
            :||.:|....:....|||||.||||.:.|...|.|:|||.|::|.|||....:|..::||..||.
Zfish    96 RLFSHLLLVDEQTASTTDLTDSFGWTNNEEMGQQDVQELNRILFSALESSLVDTSGSSLIHRLYH 160

  Fly   509 GKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEAL-RAFVQPETLDGNNQYLCEK 572
            |.:.:.:.|.||:....|::.|||:.:.|      |....:|||| ..||:.|..:|||.|.|..
Zfish   161 GTLVNQITCKECSYISERQEDFLDLTVSV------SGVSGLEEALWNMFVEEEMFEGNNLYRCSG 219

  Fly   573 CKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQN 637
            |.:...|.|....:..|..||:.|.||:||:....|.|......||.|.||..|..:|
Zfish   220 CGQLVRAAKSAKLRKLPPFLTISLLRFNFDFTKCERYKETGSYVFPLTFNLRPFCEQS------- 277

  Fly   638 SQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPY 702
                      :..||                                                .|
Zfish   278 ----------NWPDS------------------------------------------------EY 284

  Fly   703 LYELFAIMIHSGSASGGHYYAYIKDFDN-NEWFCFNDQNVTSITQEDIQRSFGGPNGSYYSSAYT 766
            .||||:::||.|...||||:.||||.|. ..|                             .|..
Zfish   285 SYELFSVIIHKGGCYGGHYHVYIKDIDQLGHW-----------------------------EAPE 320

  Fly   767 SSTNAYMLMYRQVDAKRNELVAKVADFPEHIKT-----LLPKLHSEEETR---VSRLGRHITVTD 823
            ...|..|.:..|  .:.|:...:..:....::|     :|..:.::||::   |.:||:.:
Zfish   321 EEKNVKMKVKTQ--KQENKTEERKTESENSLETEDPLSVLTGILAQEESKCVLVDQLGQKL---- 379

  Fly   824 LALPDLYKPRVYFYNPSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFAPLSRCRLVAYNSSM 888
                 |.|    ...|..||      |..|..:|:..|.|     :.|.|..:|....||..:.:
Zfish   380 -----LNK----IGTPWSKK------YKKQYGSISKFLQS-----HPEVFMLISNGTRVALKAGV 424

  Fly   889 DT------IIQSLESCTDPALTE---LRAAQN--------YSL-----------DFLLEYRAEDQ 925
            .|      ::.|..:.:.|..||   ..|.:|        :.|           |...:::.::.
Zfish   425 PTEASPPELVNSTAADSCPENTEPETATAGENEDPDQCHWFDLNDSTVTAITVKDIEKQFQGKES 489

  Fly   926 EFEVY--------PPNGITWYVFKVDLSTMAMDGPFLVYSAARE-------REASDVLRRSIALR 975
            .:.::        ||..|....:||.        |.|:.....|       |...|....||.:|
Zfish   490 AYMLFYRKTTLKRPPEAIGNPAYKVP--------PHLLEMVEEENAGLQHKRAEFDASSNSIEVR 546

  Fly   976 LHIS-EQQFLLATVRATVPK----AFVSYDPHPTPE----ALQHLQ-----NMANTQFKSITYFY 1026
            ||:: ...:....:..:.|.    ..|::|...|..    |:..:|     :||.|..|
Zfish   547 LHLAPHYHWQNGALHPSAPGEDSIITVTFDRRKTVGDLRLAIYQMQDLWEGDMALTLAK------ 605

  Fly  1027 LNVP---------NTDAATLEMLGV----------------------------------PTVESV 1048
             |||         ..|..:|...||                                  |:||.:
Zfish   606 -NVPAGLHLYDTLTDDQMSLYSAGVRNGSDLFVWNGREVSGVVVQTGVEWEPVLLTVLRPSVEEL 669

  Fly  1049 ECASGGDVVDAAM---MNGVAPGH-----MSSSNDYDWRRYKRDLVEPMSQPSPSHGHESN---- 1101
            .|:...|...:.:   |.|.|.|.     :.:....|     ..|.:..|:|..|.|..|.
Zfish   670 GCSEVSDTDGSGLVRFMKGFAGGATLGTVLEALGPQD-----ALLCQEQSRPGASGGGASGWRVF 729

  Fly  1102 -SEDSS-------LSDGDRTLV----ETDNMAHRGGGDSQVSSTSHS----------PQLSSPED 1144
             .:|..       |.|||..|:    |.|:......|| .|:.|:.|          ||....|:
Zfish   730 PPQDMQRTLRELFLKDGDALLLLQPEELDSSIFSLSGD-VVTVTTPSDCRWLQVEFCPQSGLKEE 793

  Fly  1145 EAASHDAMMRVHAYCNGNGSYAAADV----VDPLLLPTSTNHFFYATKVECVDVVGTGSSSGHQS 1205
            :....:...:..:..:.:|:...|.|    ::.|.|.....      .|||.
Zfish   794 QEEEEEEQGKKRSKVSASGNMLLAVVKQKAIEELCLQDELG------GVECC------------- 839

  Fly  1206 DEEAQLRKPTRAYKLLVGTHMRMGAFKKHIEQLIQ-------VPAA-----HFKLQRKHDNNLSN 1258
                 ||:..|..|||...|..:......|..:..       ||.|     :|.:      .|..
Zfish   840 -----LRQMDRTGKLLPPVHEHLSVRDAGIRLMTSLYLCPGPVPTATQLFLYFSV------GLVP 893

  Fly  1259 NQNNSLVHLIEGETLTVE--LGKTLEPDEFKAKIHFLRLADIDNETSKLPCVCEWVYNANTTAEQ 1321
            :....|..::| |:|||:  |.|.||....:.:...||..|...|      :.|.:.:.|.:.::
Zfish   894 SVGQELEIIVE-ESLTVKECLKKMLEMTRLEGESWHLRRVDWCEE------IGEPLMDENASLKE 951

  Fly  1322 AK----KELVAKLHRIDAK-YATLSV------------------QNC------------------ 1345
            ||    ..||....|:..| :..|||                  ||.
Zfish   952 AKVIYGDTLVLIEGRLPPKGFLKLSVRMYMDMIDSCPELNHSKPQNAEGLATECSGSEMRFMGYV 1016

  Fly  1346 --------------------------------RIWLKGGRIPIKILSDDETLYCDMRSSIAAEFI 1378
                                            |:||..|:...:||..::.....::....||..
Zfish  1017 EISEEASLDDFKTQVMTLPALQDVCVPSPAFMRVWLLEGKKLARILRGNQMTLRKLKLGNGAEVC 1081

  Fly  1379 VQECEEEVDPQPKDDSLTLFVRRWCPAKLEFGKFQEITLD--QDSEIRLSLSQISDIPIDKLSYM 1441
            :|...:|.|...||  |.|.|:...|.:..:...:|...|  :|..             .|..|.
Zfish  1082 IQRLMKEEDLGLKD--LLLRVQMGVPGEKAYYPSEEFLWDAGRDGS-------------PKGLYA 1131

  Fly  1442 KLNSNF---PCTSISALSVNESSSW-------YSVPTTLDKYPLNSTQTGNIYLYKDRTVPAREL 1496
            .|.:::   |...:.|..:.:..||       ..|.....|....|.|....||.....:..:.|
Zfish  1132 ALAAHYGLAPDNLLLAKHLPDKHSWMPISNWTQQVSKRKKKRKAESLQAAPFYLKDGDIIGVKNL 1196

  Fly  1497 TLEERRLMNAREKARLDRVGCVSTTRYAQRRERALKIYLDSPEKSSNVTASAPMD 1551
            .::..:.....|    |.:|     :...|.|.|     :...:.|.||..:.:|
Zfish  1197 LIDNNKEFTTLE----DEIG-----QLRLREEVA-----NQNTRGSTVTGESSLD 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066
		peptidase_C19C	394..780	CDD:239124	118/400 (30%)
		USP47_C	1300..1534	CDD:466158	54/318 (17%)
usp40	XP_001921353.3	Peptidase_C19	37..316	CDD:470612	112/349 (32%)