Protein Alignment Usp47 and Usp15-31

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: NP_611959.2
• Gene: Usp15-31 / 37954
• FlyBaseID: FBgn0050421
• Length: 1272
• Species: Drosophila melanogaster
• Alignment Length: 1385
• Identity: 247/1385 - (17%)
• Similarity: 426/1385 - (30%)
• Gaps: 491/1385 - (35%)

  Fly    15 DQTPGSEQKK-------INVVVR--SHFTVKRVIDLIGTQFSYEKFELLLQPHDNKDLVNLNALE 70
            |||||....|       :|.|::  ||      .|::...|..::::        .||...|.:.
  Fly   259 DQTPGVMGLKNHGNTCFMNAVLQCLSH------TDILAEYFVLDQYK--------ADLKRRNKIN 309

  Fly    71 SQLMYEVAGFEPQLKNHLILLPSGSWDGDVTKRFELPIKRVVVKKVMKSDGEKAKSPATGEKKKR 135
            |:..........||.|.|..|.:...:.|.:..|         |.|:...|.:.:|....:.::.
  Fly   310 SRKFGTKGELTEQLANVLKALWTCKNESDHSTSF---------KAVVDRYGTQFRSSTQHDAQEF 365

  Fly   136 VVGEKTKKKPASGSSSPSKAKTTSEDSLAKTSISSESSPEKTSKIKTTAAKISKPGS-----EKA 195
            :.....|......::|..:.|:..         :|....::....:|.|..|....|     .:|
  Fly   366 LFWLLDKVHEDLNTASKRRYKSLK---------NSYGRSDEVIAAETLANHIRCNNSFVQAVFQA 421

  Fly   196 PRASPEECPELSTEINSKN----TSSESP-VAKKTAKVT-------------------SKPTLEL 236
            ...|...||....:.|:.:    .|.:.| :.::|..||                   ..|.:.|
  Fly   422 QFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVAL 486

  Fly   237 LSPIKPSSPIKE-----------------LDCEPVDTLSKQQLSEQLQLYPQGRNLISPVDDAPS 284
            ...::..:.|:.                 .|.:||:|||..:....::: |..    :||..|
  Fly   487 REQLQADTGIEGSRMVLVDLNAEGFTRVFYDTQPVETLSSIETIYCIEV-PAA----TPVAKA-- 544

  Fly   285 DLFISDAEQLSDDDLALGASASPTMLGPGYDYGAPTGDSDVEGVTGVTDPSTIGTDDGTYPALSN 349
                                |:|:..|   |..|||      .||  ..|:...:.......::|
  Fly   545 --------------------ATPSETG---DKSAPT------AVT--PSPAAAQSQADLLLLVAN 578

  Fly   350 FYRRKYGGDELRAWQRVNTTGADFVSSATTETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQAL 414
            .||.|.|.|       :...||.|...|..:...:..|..: .|....|:...:..|...|.:.
  Fly   579 VYRAKDGAD-------ITRFGAPFSMKAPRDCSYQDLQKRM-LREMAPLLKPEVFSYATPLAEM- 634

  Fly   415 FMTPEFRNALYRWEFDNDNEAKNIPYQLQKLFLNLQ---TSPKAAVETTDLTRSFGWDSTEAW-- 474
                 ||..|.....|.|...:.:.:.|....:::.   .|.:|..:...|.  ..|.|.||.
  Fly   635 -----FRIRLQDPSADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLL--LEWSSPEAHFI 692

  Fly   475 -QQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPVR 538
             :|.|.:|.      .:||:        .::.|...|.:|
  Fly   693 SKQQDTEEA------VVEHE--------SVARLSASKPSD------------------------- 718

  Fly   539 PFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDY 603
                 :|..::|:.|..:.:.|||...:.:.|..|::.....|.|...|.|.||.:|.|||
  Fly   719 -----TAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRF---- 774

  Fly   604 QTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTT 668
             ..|:.|      .||...|.|.:           :...|..|.|          .:|:.||..:
  Fly   775 -RQHQSK------GPQAAKLTTMV-----------KFPLTAFDMS----------PHLARGVHES 811

  Fly   669 ASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPY----------------------LYELFAIMI 711
            ||||            :.|.:........||.|:                      .|:|:|:..
  Fly   812 ASSS------------LGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCY 864

  Fly   712 HSG-SASGGHYYAYIKDFDNNEWFCFNDQNVTSITQEDIQRSFGGPNGSYYSSAYTSSTNAYMLM 775
            |.| :...|||.|..|:..:.:|:.|:||.|:.:.::||::..             .:..||||.
  Fly   865 HQGDTLETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDI-------------INNEAYMLF 916

  Fly   776 Y--RQVDAKRNELVAKVADFPEHIKTLLPKLHSEEETRVSRLGRHITVTDLALPDLYKPRVYFYN 838
            |  |.|||                        .|.....|..|.|.
  Fly   917 YQRRSVDA------------------------GECSGSSSNSGDHW------------------- 938

  Fly   839 PSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFAPLSRCRLVAYNSSMDTIIQSLESCTDPAL 903
                                           |.:.||.|.....:.:......::..|:...||.
  Fly   939 -------------------------------VSRIAPASSSSASSTSGKEREPVKLEENTESPAA 972

  Fly   904 TEL-RAAQNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAAREREASDV 967
            .|: ..||:..:|.:.:.:|:.                       ..|||           .:|.
  Fly   973 VEVTEKAQSKPVDIVCQDKAKG-----------------------TADGP-----------DADQ 1003

  Fly   968 LRRSIALRLHISEQQFLLATVRATVP---KAFVSYDPHPTPEALQHLQNMANTQFKSITYFYLNV 1029
            .:.::...|.|.|..|..|.|..::.   ||.|:......|:.::        ..::...|.::.
  Fly  1004 EQTTVPHDLQIEELAFADADVDTSLGETIKAEVNLAAKDEPKKVE--------VEEATPIFAMDE 1060

  Fly  1030 PNTDAATLEMLGVPTVESVECASGGDVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVEPMSQPSP 1094
            ..::|.        ..:..||....|             .:|.:.|          |..::..|.
  Fly  1061 DGSEAR--------QEKKEECVKKED-------------ELSEAPD----------VSELTAESK 1094

  Fly  1095 SHGHESNSEDSSLSDGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMMRVH--- 1156
            ::||.|:|..||.|                  :|.:||.|....||:....|::..:....|
  Fly  1095 TNGHVSSSSSSSSS------------------ESSLSSRSSPRSLSTSVTAASTLQSKFNGHMSA 1141

  Fly  1157 --AYCNGNGSYAAADVVDPLLLPTSTNHFFYATK--VECVDVVGTGSSSGHQSDEEAQLRKPTRA 1217
              |..||||:.:.......|......||.::.::  |..|:     :::.||..:.|.
  Fly  1142 APALFNGNGNTSQLSSSLQLSRHVLHNHQWHGSRSSVSAVE-----NATQHQQQQAAA------- 1194

  Fly  1218 YKLLVGTHMRMGAFKKHIEQLIQVPAAHFKLQRKHDNNLSNNQNNSLVHLIEGETLTVELGKTLE 1282
                                         .|..:|..:.|:|...:|..|:.....|......|.
  Fly  1195 -----------------------------SLSLRHSFSTSSNYTETLSSLLRKSANTCSKDTLLF 1230

  Fly  1283 PDEFKAKIHFLRLADIDNET 1302
            .|: ::..|...|.:.|:::
  Fly  1231 IDQ-QSHHHTAGLIEDDDDS 1249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066	22/172 (13%)
		peptidase_C19C	394..780	CDD:239124	85/416 (20%)
		USP47_C	1300..1534	CDD:466158	0/3 (0%)
Usp15-31	NP_611959.2	UBP12	<255..921	CDD:227847	164/848 (19%)