Protein Alignment Usp47 and Usp7

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: XP_063125353.1
• Gene: Usp7 / 360471
• RGDID: 1306915
• Length: 1161
• Species: Rattus norvegicus
• Alignment Length: 1159
• Identity: 261/1159 - (22%)
• Similarity: 432/1159 - (37%)
• Gaps: 372/1159 - (32%)

  Fly   340 DDGTYP-ALSNFYRRK---YGGDELRAWQRVNTTGADFV--SSATTE--TEAEARQA----SLGP 392
            ||.::. .:|:.:..|   :|.....||..|......|:  ...|.|  .:|:|...    |...
  Rat   185 DDKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKH 249

  Fly   393 RGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQKLFLNLQTSPKAAV 457
            .|||||.||..|||:|||||.||.|.:.|.|:|....:.|:.:|::|..||::|..||.|.| .|
  Rat   250 TGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK-PV 313

  Fly   458 ETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNT 522
            .|..||:||||::.:::.|||:||||||:.|.:|:|.|.|.....|..|:.|||..|::|.|.:.
  Rat   314 GTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDY 378

  Fly   523 EKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKS 587
            ...|.:.:.||.|.::  |..:.:.|..:    :|..|.|||:|:|...:...: :|.||:.|.:
  Rat   379 RSDRREDYYDIQLSIK--GKKNIFESFVD----YVAVEQLDGDNKYDAGEHGLQ-EAEKGVKFLT 436

  Fly   588 FPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADS 652
            .|.:|.|.|.||.:|.||...||:|||..||:.|.|:.|:.::
  Rat   437 LPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKT---------------------- 479

  Fly   653 GSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSAS 717
                                    |..|                    |..|.|.|:::|||...
  Rat   480 ------------------------DPKD--------------------PANYILHAVLVHSGDNH 500

  Fly   718 GGHYYAYIKDFDNNEWFCFNDQNVTSITQED-IQRSFGGPNGSYYSSAYTSSTNAYMLMYRQVDA 781
            ||||..|:....:.:|..|:|..|:..|:|: |:.::||.:...   :....||||||:|.: ::
  Rat   501 GGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDL---SVRHCTNAYMLVYIR-ES 561

  Fly   782 KRNELVAKVA--DFPEHIKTLLPKLHSEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKM 844
            |.:|::..|.  |.|:.:...|     :||.|:....|                        |:.
  Rat   562 KLSEVLQAVTDHDIPQQLVERL-----QEEKRIEAQKR------------------------KER 597

  Fly   845 KITRVYVSQSFNINLVLMSAY------EMLNVEQFAPLSRCRLVAY----NSSMDTIIQSLESCT 899
            :...:|:    .:.:|....:      :|.:.|      :.|...:    |||:...:|||....
  Rat   598 QEAHLYM----QVQIVAEDQFCGHQGNDMYDEE------KVRYTVFKVLKNSSLAEFVQSLSQTM 652

  Fly   900 DPALTELRAAQNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAAREREA 964
            .....::|.       :.::.|:...:......|........::||.  .:.|:.::....:.|
  Rat   653 GFPQDQIRL-------WPMQARSNGTKRPAMLDNEADGSKTMIELSD--NENPWTIFLETVDPE- 707

  Fly   965 SDVLRRSIALRLHISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYF-YLN 1028
                                ||...||:||....:|       :.....|.:.:.:|:.|. ::.
  Rat   708 --------------------LAASGATLPKFDKDHD-------VMLFLKMYDPKTRSLNYCGHIY 745

  Fly  1029 VPNTDAATLEMLGVPTVESVECASGGDVVDAAMM--NGVAPGHMSSSNDYDWRRYKRDLVEPMSQ 1091
            .| ......::|      .|.|...|.:.|.:::  ..|.|.......|||
  Rat   746 TP-ISCKIRDLL------PVMCDRAGFIQDTSLILYEEVKPNLTERIQDYD-------------- 789

  Fly  1092 PSPSHGHESNSEDSSLS---DGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMM 1153
                     .|.|.:|.   |||..:.:.|:                      ||::.:.
  Rat   790 ---------VSLDKALDELMDGDIIVFQKDD----------------------PENDNSE----- 818

  Fly  1154 RVHAYCNGNGSYAAADVVDPLLLPTSTNHF--FYATKVECVDVVGTGSSSGHQSDEEAQLRKPTR 1216
                                  |||:..:|  .|    ..|||:....:..:...
  Rat   819 ----------------------LPTAKEYFRDLY----HRVDVIFCDKTIPNDPG---------- 847

  Fly  1217 AYKLLVGTHMRMGAFK--KHIEQ-------LIQVPAAHFKLQRKHDNNLSNNQNNSLVHLIEGET 1272
               .:|....||..|:  |.:.|       |:|    .||.|...|     ...|.|.|..|| |
  Rat   848 ---FVVTLSNRMNYFQVAKTVAQRLNTDPMLLQ----FFKSQGYRD-----GPGNPLRHNYEG-T 899

  Fly  1273 LTVELGKTLEPDEFKAKIHF----LRLADIDNETSKLPCVCEWVYNANTTAEQAKKELVAKLHRI 1333
            |. :|.:..:|.:.| |:::    :::.|.:|..| ..|
  Rat   900 LR-DLLQFFKPRQPK-KLYYQQLKMKITDFENRRS-FKC-------------------------- 935

  Fly  1334 DAKYATLSVQNCRIWLKGGRIPIKILSDDETLYCDMRSSIAAEFIVQECEEEVDPQPK-DDSLTL 1397
                         |||..     :...::.|||.|....:  ..:::||::.|:...| ...|.|
  Rat   936 -------------IWLNS-----QFREEEITLYPDKHGCV--RDLLEECKKAVELGDKASGRLRL 980

  Fly  1398 FVRRWCPAKLEFGKFQEITLDQDSEIRLSLS-------QISDIPIDKLSYMKLN 1444
                     ||...::.|.:.|:.|:...||       :|.:||:|::...|.|
  Rat   981 ---------LEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKEN 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066
		peptidase_C19C	394..780	CDD:239124	127/386 (33%)
		USP47_C	1300..1534	CDD:466158	29/153 (19%)
Usp7	XP_063125353.1	None