Protein Alignment Usp47 and Usp24

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: XP_006503239.1
• Gene: Usp24 / 329908
• MGIID: 1919936
• Length: 2637
• Species: Mus musculus
• Alignment Length: 1505
• Identity: 324/1505 - (21%)
• Similarity: 531/1505 - (35%)
• Gaps: 451/1505 - (29%)

  Fly     2 TDKESEQCTVSVFDQTP-GSEQKKINVVVRSHFTVKRVIDLIGTQFSYEKFELLLQPHDNKDLVN 65
            |.::...|      .|| .|..::::|..||...|:.:|...         .:.:|..:..|...
Mouse  1297 TSRQMSLC------GTPEKSSYRQLSVSDRSSIRVEEIIPAA---------RVAIQTMEASDFTA 1346

  Fly    66 LNALESQLMY-------EVAGFEPQLKNHLILLPSGSWDGDVTKRFELPIKRVVVKKVMKSDGEK 123
            ..|...:|.:       ::.|....:|....|.|:|                  ::..:.|.|..
Mouse  1347 TVACFMRLSWAAAAGRLDLVGSSQPIKESNSLFPAG------------------IRSRLSSSGSN 1393

  Fly   124 AKSPATGE-----------------KKKRVVGEK----------TKKKPASGSSSPSKAKTTSED 161
            ..|.:.||                 |...:.||.          ..::.||..|.|..|     |
Mouse  1394 CSSSSEGEPAALHAGICVRQQSVSTKDALIAGEALSLLVTCLQLRSQQLASFYSLPCVA-----D 1453

  Fly   162 SLAKTSISSESSPEK---------TSKIKTTA-AKISKPG--------SEKAPRASP-------- 200
            .:....:.|.|:..:         .|:..|:| .::.||.        :.:.|..||
Mouse  1454 FIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPEVQKPNQFLLGVILTAQLPLWSPTSIMRGVN 1518

  Fly   201 ----EECPE---LSTEINSKNTSSE------SPVAKKTAKVTSKPTLELLSPIKPSSPIKELDCE 252
                .:|.|   |..::....|:||      ||......::|.....|         |.:..|||
Mouse  1519 QRLLSQCMEYFDLRCQLLDDLTTSEMDQLRISPATMLEDEITWLDNFE---------PNRTADCE 1574

  Fly   253 PVDT----------LSKQQLS----EQLQLYPQGRNLISP-VDDAPSDLFISDAEQLSDDDLALG 302
            ..:.          |.|..||    |:..|   |.:||.| :||.   ||.:....::....|..
Mouse  1575 TSEADNILLAGHLRLIKTLLSLCGAEKEML---GSSLIKPLLDDF---LFRASRIIVNSHSPASS 1633

  Fly   303 ASASPTMLGP----------GYDYGAPTGDSDVEGVTGVTDPSTIGTDDGTYPALSNFYRRKYGG 357
            |:.|.....|          .|:......||....:..:| ...:.......|||:..:
Mouse  1634 AAISQQDFHPKCSTVNSRLAAYEVLVMLADSSPSNLQIIT-KELLSMHHQPDPALTKEF------ 1691

  Fly   358 DELRAWQRVNTTGADFVSSATTETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRN 422
                          |::      ...::|.:|    |:|||.|...|||:|::.|.|:|.|....
Mouse  1692 --------------DYL------PPVDSRSSS----GFVGLRNGGATCYMNAVFQQLYMQPGLPE 1732

  Fly   423 ALYRWEFDNDNEAKNIPYQLQKLFLNLQTSPKAAVETTDLTRSFGWDSTEAW--QQHDIQELCRV 485
            :|...:.|.||...::.||:|.||.:|..|........:..:.|...:.|.:  :|.|..|....
Mouse  1733 SLLSVDDDTDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTS 1797

  Fly   486 MFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIE 550
            :.|.::...|...:..:..|.::|..:|...|.:|.....||:.|:.:.|.|      ::..|:|
Mouse  1798 LIDQMDEYLKKMGREQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGV------TSCQSLE 1856

  Fly   551 EALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRV 615
            .:|..||:.|.|:|:|.|.|||||:|....|....||.|.:|.:||.||.||:::...||.::::
Mouse  1857 ISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQI 1921

  Fly   616 TFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLN- 679
            .||..||:..:                ||       :|.|.:|          :||...||..|
Mouse  1922 RFPWMLNMEPY----------------TV-------AGMARQD----------SSSEVGENGRNM 1953

  Fly   680 DEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYIKD---FDNNEWFCFNDQNV 741
            |:..|   .|...|.|...:    |||..:::|||.|..||||::|||   ....:|:.|||
Mouse  1954 DQGGG---GSPRKKVALTEN----YELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFND--- 2008

  Fly   742 TSITQEDIQ------RSFGG---PNGSYYSSAYTSST----NAYMLMYRQVDAKRNELVAK---- 789
            |.|.:.|:.      ..|||   |.....::.||...    |||||.|::|..:.:.::.|
Mouse  2009 TVIEEFDLNDETLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRV 2073

  Fly   790 -------------VADFPEHIKTLLPKLHSEEETRVSRLGRHITVTDL--ALPDLYKPRVY--FY 837
                         ....||......|:.|.....|:|.|.:.:...:.  ...:....|:|  ..
Mouse  2074 SVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIYQMVR 2138

  Fly   838 NPSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFA-PLSRCRL-VAYNSSMDTIIQS------ 894
            :.:||.||...||.|..|:..|.|.|    ||..:.. |...|.. |:...::..:.|:
Mouse  2139 DENLKFMKNRDVYSSDYFSFVLSLAS----LNATKLKHPYYPCMAKVSLQLAIQFLFQTYLRTKK 2199

  Fly   895 -LESCTDPALTELRAAQNYSLD---FLLEY--RAEDQEF-EVY-------------------PPN 933
             |...|:..:..:.|..:.|||   :|:||  .:|.:|. :|:                   ..:
Mouse  2200 KLRVDTEEWIATIEALLSKSLDACQWLVEYFISSEGRELVKVFLLECSVREVRVAVATILEKTLD 2264

  Fly   934 GITWY---------VFKVDLSTMAMDGP---------FLVYSAARERE---ASDVLRRSIALRLH 977
            ...:|         :.:|.|:.:..|.|         |.:::...:::   |.|:|.|..|||..
Mouse  2265 SALFYQDKLKSLHQLLEVLLALLDKDVPENCKNCAQYFSLFNTFVQKQGIRAGDLLLRHSALRHM 2329

  Fly   978 ISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYFYLNVPNTDAATLEMLGV 1042
            ||   |||...|..                 ..::..::.|.:.    :.|:.||.|..:
Mouse  2330 IS---FLLGVSRQN-----------------SQIRRWSSAQARE----FGNLHNTVALLV----- 2365

  Fly  1043 PTVESVECASGGDVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVEPMSQPSPSHGHESNSEDSSL 1107
              :.|          |.:....||||.........        |.|.|...|.  ||.......|
Mouse  2366 --LHS----------DVSSQRNVAPGIFKQRPPIS--------VAPSSPLLPL--HEEVEALLFL 2408

  Fly  1108 SDGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMMRVHAY---CNGNGSYAAAD 1169
            |:|...|:|.                     :.:..:...|..|:|.:..|   ||.:.|:....
Mouse  2409 SEGKPYLLEV---------------------MFALRELTGSLLALMEMVVYCCFCNEHFSFTMLH 2452

  Fly  1170 VVDPLLLPTSTNHFFYAT--------------KVECVDVV-----GTGSSSGHQSDEEAQLRKPT 1215
            .:.. .|.|:..|....|              :||.|..|     |..:...|.:..::     :
Mouse  2453 FIKN-QLETAPPHELKNTFQLLHEVLVIEDPIQVERVKFVFETENGLLALMHHSNHVDS-----S 2511

  Fly  1216 RAY---KLLVGTHMRMGAFKKHIEQLIQVPAAHFK-----LQRKHDNNLSNNQNNSLVHLIEGET 1272
            |.|   |.||....:..|.|::.::    .:.|:.     ||:|...:....|:|     :..||
Mouse  2512 RCYQCVKFLVTLAQKCPAAKEYFKE----NSHHWSWAVQWLQKKMSEHYWTPQSN-----VSNET 2567

  Fly  1273 LTVELGKTLE 1282
            .|   |||.:
Mouse  2568 ST---GKTFQ 2574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066	33/192 (17%)
		peptidase_C19C	394..780	CDD:239124	122/404 (30%)
		USP47_C	1300..1534	CDD:466158
Usp24	XP_006503239.1	UBA_UBP24	6..42	CDD:270472
		Ubl_UBP24	972..1050	CDD:340585
		peptidase_C19C	1704..2061	CDD:239124	123/405 (30%)