Protein Alignment Usp47 and Usp7

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: XP_006522201.1
• Gene: Usp7 / 252870
• MGIID: 2182061
• Length: 1143
• Species: Mus musculus
• Alignment Length: 1159
• Identity: 260/1159 - (22%)
• Similarity: 432/1159 - (37%)
• Gaps: 372/1159 - (32%)

  Fly   340 DDGTYP-ALSNFYRRK---YGGDELRAWQRVNTTGADFV--SSATTE--TEAEARQA----SLGP 392
            ||.::. .:|:.:..|   :|.....||..|......|:  ...|.|  .:|:|...    |...
Mouse   187 DDKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKH 251

  Fly   393 RGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQKLFLNLQTSPKAAV 457
            .|||||.||..|||:|||||.||.|.:.|.|:|....:.|:.:|::|..||::|..||.|.| .|
Mouse   252 TGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK-PV 315

  Fly   458 ETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNT 522
            .|..||:||||::.:::.|||:||||||:.|.:|:|.|.|.....|..|:.|||..|::|.:.:.
Mouse   316 GTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKDVDY 380

  Fly   523 EKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKS 587
            ...|.:.:.||.|.::  |..:.:.|..:    :|..|.|||:|:|...:...: :|.||:.|.:
Mouse   381 RSDRREDYYDIQLSIK--GKKNIFESFVD----YVAVEQLDGDNKYDAGEHGLQ-EAEKGVKFLT 438

  Fly   588 FPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADS 652
            .|.:|.|.|.||.:|.||...||:|||..||:.|.|:.|:.::
Mouse   439 LPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKT---------------------- 481

  Fly   653 GSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSAS 717
                                    |..|                    |..|.|.|:::|||...
Mouse   482 ------------------------DPKD--------------------PANYILHAVLVHSGDNH 502

  Fly   718 GGHYYAYIKDFDNNEWFCFNDQNVTSITQED-IQRSFGGPNGSYYSSAYTSSTNAYMLMYRQVDA 781
            ||||..|:....:.:|..|:|..|:..|:|: |:.::||.:...   :....||||||:|.: ::
Mouse   503 GGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDL---SVRHCTNAYMLVYIR-ES 563

  Fly   782 KRNELVAKVA--DFPEHIKTLLPKLHSEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKM 844
            |.:|::..|.  |.|:.:...|     :||.|:....|                        |:.
Mouse   564 KLSEVLQAVTDHDIPQQLVERL-----QEEKRIEAQKR------------------------KER 599

  Fly   845 KITRVYVSQSFNINLVLMSAY------EMLNVEQFAPLSRCRLVAY----NSSMDTIIQSLESCT 899
            :...:|:    .:.:|....:      :|.:.|      :.|...:    |||:...:|||....
Mouse   600 QEAHLYM----QVQIVAEDQFCGHQGNDMYDEE------KVRYTVFKVLKNSSLAEFVQSLSQTM 654

  Fly   900 DPALTELRAAQNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAAREREA 964
            .....::|.       :.::.|:...:......|........::||.  .:.|:.::....:.|
Mouse   655 GFPQDQIRL-------WPMQARSNGTKRPAMLDNEADGNKTMIELSD--NENPWTIFLETVDPE- 709

  Fly   965 SDVLRRSIALRLHISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYF-YLN 1028
                                ||...||:||....:|       :.....|.:.:.:|:.|. ::.
Mouse   710 --------------------LAASGATLPKFDKDHD-------VMLFLKMYDPKTRSLNYCGHIY 747

  Fly  1029 VPNTDAATLEMLGVPTVESVECASGGDVVDAAMM--NGVAPGHMSSSNDYDWRRYKRDLVEPMSQ 1091
            .| ......::|      .|.|...|.:.|.:::  ..|.|.......|||
Mouse   748 TP-ISCKIRDLL------PVMCDRAGFIQDTSLILYEEVKPNLTERIQDYD-------------- 791

  Fly  1092 PSPSHGHESNSEDSSLS---DGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMM 1153
                     .|.|.:|.   |||..:.:.|:                      ||::.:.
Mouse   792 ---------VSLDKALDELMDGDIIVFQKDD----------------------PENDNSE----- 820

  Fly  1154 RVHAYCNGNGSYAAADVVDPLLLPTSTNHF--FYATKVECVDVVGTGSSSGHQSDEEAQLRKPTR 1216
                                  |||:..:|  .|    ..|||:....:..:...
Mouse   821 ----------------------LPTAKEYFRDLY----HRVDVIFCDKTIPNDPG---------- 849

  Fly  1217 AYKLLVGTHMRMGAFK--KHIEQ-------LIQVPAAHFKLQRKHDNNLSNNQNNSLVHLIEGET 1272
               .:|....||..|:  |.:.|       |:|    .||.|...|     ...|.|.|..|| |
Mouse   850 ---FVVTLSNRMNYFQVAKTVAQRLNTDPMLLQ----FFKSQGYRD-----GPGNPLRHNYEG-T 901

  Fly  1273 LTVELGKTLEPDEFKAKIHF----LRLADIDNETSKLPCVCEWVYNANTTAEQAKKELVAKLHRI 1333
            |. :|.:..:|.:.| |:::    :::.|.:|..| ..|
Mouse   902 LR-DLLQFFKPRQPK-KLYYQQLKMKITDFENRRS-FKC-------------------------- 937

  Fly  1334 DAKYATLSVQNCRIWLKGGRIPIKILSDDETLYCDMRSSIAAEFIVQECEEEVDPQPK-DDSLTL 1397
                         |||..     :...::.|||.|....:  ..:::||::.|:...| ...|.|
Mouse   938 -------------IWLNS-----QFREEEITLYPDKHGCV--RDLLEECKKAVELGDKASGRLRL 982

  Fly  1398 FVRRWCPAKLEFGKFQEITLDQDSEIRLSLS-------QISDIPIDKLSYMKLN 1444
                     ||...::.|.:.|:.|:...||       :|.:||:|::...|.|
Mouse   983 ---------LEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKEN 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066
		peptidase_C19C	394..780	CDD:239124	126/386 (33%)
		USP47_C	1300..1534	CDD:466158	29/153 (19%)
Usp7	XP_006522201.1	Peptidase_C19	96..1141	CDD:470612	260/1159 (22%)