Protein Alignment Usp47 and USP24

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: XP_016856320.1
• Gene: USP24 / 23358
• HGNCID: 12623
• Length: 2640
• Species: Homo sapiens
• Alignment Length: 1546
• Identity: 326/1546 - (21%)
• Similarity: 529/1546 - (34%)
• Gaps: 529/1546 - (34%)

  Fly    62 DLVNLNALESQLMYE----VAGFEPQLKNHLIL---LPSGSWDGDVTKRFELPIKRVVVKKVMKS 119
            :::..:::.|::.||    |.....||...|::   :|: ..|.|:||
Human  1236 NVMQRDSIPSEVDYETRQGVYSICLQLARFLLVGQTMPT-LLDEDLTK----------------- 1282

  Fly   120 DGEKAKSPATGEKKKRVVGEKTKKKPASGSSSPSKAKTTSEDSLAKTSISSESS-------PEKT 177
            ||.:|.|    .:..|.|..:|       |...|...|..:.|..:.|:|..||       |...
Human  1283 DGIEALS----SRPFRNVSRQT-------SRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAAR 1336

  Fly   178 SKIKT--------------------TAAKISKPGSEKAPRASPEECP-----ELSTEINSKNTSS 217
            ..|:|                    .|.::...||.:..:.|...||     .||:..::.::.|
Human  1337 VAIQTMEVSDFTSTVACFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSGS 1401

  Fly   218 E-SPVA------KKTAKVTSKPTL---ELLSPI------------------------------KP 242
            | .|||      .:...|::|.:|   |.||.:                              .|
Human  1402 EGEPVALHAGICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVADFIIDILLGSP 1466

  Fly   243 SSPIKELDCEPVDTLSKQQ------------------LSEQLQLYP-----QGRN--LISP---- 278
            |:.|:.:.|:.:.|||:..                  |:.||.|:.     :|.|  |:|.
Human  1467 SAEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPTSIMRGVNQRLLSQCMEY 1531

  Fly   279 -------VDDAPS----DLFISDAEQLSD---------------------DDLALG--------- 302
                   :||..:    .|.||.|..|.|                     |::.|.
Human  1532 FDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSEADNILLAGHLRLIKTL 1596

  Fly   303 ---ASASPTMLGPGY------DY-----------GAPTGDSDVEGVTGVTDPSTIGTDDGTYPAL 347
               ..|...|||...      |:           .:|.|.:.:             :....:|..
Human  1597 LSLCGAEKEMLGSSLIKPLLDDFLFRASRIILNSHSPAGSAAI-------------SQQDFHPKC 1648

  Fly   348 SNFYRRKYGGDELRAWQRVNTTGADFVSS-------------------ATTETE----AEARQAS 389
            |.      ....|.|:: |....||...|                   .|.|.:    .::|.:|
Human  1649 ST------ANSRLAAYE-VLVMLADSSPSNLQIIIKELLSMHHQPDPALTKEFDYLPPVDSRSSS 1706

  Fly   390 LGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQKLFLNLQTSPK 454
                |:|||.|...|||:|::.|.|:|.|....:|...:.|.||...::.||:|.||.:|..|..
Human  1707 ----GFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMESKL 1767

  Fly   455 AAVETTDLTRSFGWDSTEAW--QQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKC 517
            ......:..:.|...:.|.:  :|.|..|....:.|.::...|...:..:..|.::|..:|...|
Human  1768 QYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQKIC 1832

  Fly   518 LECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKG 582
            .:|.....||:.|:.:.|.|      ::..|:|.:|..||:.|.|:|:|.|.|||||:|....|.
Human  1833 KDCPHRYEREEAFMALNLGV------TSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKR 1891

  Fly   583 LHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDC 647
            ...||.|.:|.:||.||.||:::...||.::::.||..||:..:                ||
Human  1892 TCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPY----------------TV--- 1937

  Fly   648 STADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSG---------PYL 703
                ||.|.:|          :||...||               .:|..||.|         ...
Human  1938 ----SGMARQD----------SSSEVGEN---------------GRSVDQGGGGSPRKKVALTEN 1973

  Fly   704 YELFAIMIHSGSASGGHYYAYIKD---FDNNEWFCFNDQNVTSITQEDIQ------RSFGG---P 756
            |||..:::|||.|..||||::|||   ....:|:.|||   |.|.:.|:.      ..|||   |
Human  1974 YELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFND---TVIEEFDLNDETLEYECFGGEYRP 2035

  Fly   757 NGSYYSSAYTSST----NAYMLMYRQVDAKRNELVAK-----------------VADFPEHIKTL 800
            .....::.||...    |||||.|::|..:.:.::.|                 ....||.....
Human  2036 KVYDQTNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQS 2100

  Fly   801 LPKLHSEEETRVSRLGRHITVTDL--ALPDLYKPRVY--FYNPSLKKMKITRVYVSQSFNINLVL 861
            .|:.|.....|:|.|.:.:...:.  ...:....|:|  ..:.:||.||...||.|..|:..|.|
Human  2101 SPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSL 2165

  Fly   862 MSAYEMLNVEQFA-PLSRCRL-VAYNSSMDTIIQS-------LESCTDPALTELRAAQNYSLD-- 915
            .|    ||..:.. |...|.. |:...::..:.|:       |...|:..:..:.|..:.|.|
Human  2166 AS----LNATKLKHPYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDAC 2226

  Fly   916 ------------------FLLEYRAEDQEFEV-----YPPNGITWY---------VFKVDLSTMA 948
                              ||||....:....|     ...:...:|         :.:|.|:.:.
Human  2227 QWLVEYFISSEGRELIKIFLLECNVREVRVAVATILEKTLDSALFYQDKLKSLHQLLEVLLALLD 2291

  Fly   949 MDGP---------FLVYSAARERE---ASDVLRRSIALRLHISEQQFLLATVRATVPKAFVSYDP 1001
            .|.|         |.:::...:::   |.|:|.|..|||..||   |||...|..
Human  2292 KDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMIS---FLLGASRQN---------- 2343

  Fly  1002 HPTPEALQHLQNMANTQFKSITYFYLNVPNTDAATLEMLGVPTVESVECASGGDVVDAAMMNGVA 1066
                   ..::..::.|.:.    :.|:.||.|..:       :.|          |.:....||
Human  2344 -------NQIRRWSSAQARE----FGNLHNTVALLV-------LHS----------DVSSQRNVA 2380

  Fly  1067 PGHMSSSNDYDWRRYKRDLVEPMSQPSPSHGHESNSEDSSLSDGDRTLVETDNMAHRGGGDSQVS 1131
            ||.........        :.|.|...|.  ||.......:|:|...|:|.
Human  2381 PGIFKQRPPIS--------IAPSSPLLPL--HEEVEALLFMSEGKPYLLEV-------------- 2421

  Fly  1132 STSHSPQLSSPEDEAASHDAMMRVHAY---CNGNGSYAAADVVDPLLLPTSTNHFFYAT------ 1187
                   :.:..:...|..|::.:..|   ||.:.|:.....:.. .|.|:..|....|
Human  2422 -------MFALRELTGSLLALIEMVVYCCFCNEHFSFTMLHFIKN-QLETAPPHELKNTFQLLHE 2478

  Fly  1188 --------KVECVDVV-----GTGSSSGHQSDEEAQLRKPTRAY---KLLVGTHMRMGAFKKHIE 1236
                    :||.|..|     |..:...|.:..::     :|.|   |.||....:..|.|::.:
Human  2479 ILVIEDPIQVERVKFVFETENGLLALMHHSNHVDS-----SRCYQCVKFLVTLAQKCPAAKEYFK 2538

  Fly  1237 QLIQVPAAHFK-----LQRKHDNNLSNNQNNSLVHLIEGETLTVELGKTLE 1282
            :    .:.|:.     ||:|...:....|:|     :..||.|   |||.:
Human  2539 E----NSHHWSWAVQWLQKKMSEHYWTPQSN-----VSNETST---GKTFQ 2577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066	38/198 (19%)
		peptidase_C19C	394..780	CDD:239124	121/412 (29%)
		USP47_C	1300..1534	CDD:466158
USP24	XP_016856320.1	UBA_UBP24	6..42	CDD:270472
		Ubl_UBP24	975..1053	CDD:340585
		peptidase_C19C	1707..2064	CDD:239124	122/413 (30%)