Protein Alignment Usp47 and Usp9x

DIOPT Version :10

• Sequence 1: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Sequence 2: XP_006527649.1
• Gene: Usp9x / 22284
• MGIID: 894681
• Length: 2575
• Species: Mus musculus
• Alignment Length: 1641
• Identity: 334/1641 - (20%)
• Similarity: 551/1641 - (33%)
• Gaps: 580/1641 - (35%)

  Fly    55 LQPHDNKDLVNLNAL------------------------ESQLMY--EVAGFEPQLKNHLILLPS 93
            |.|.|:..:..|.|:                        .||::|  ||.        :.:|:|:
Mouse  1051 LMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVV--------YALLMPA 1107

  Fly    94 GSWDGDVTKRFE--------LPIKRVVVKK---VMKSDGE-------------KAKSPATGEKKK 134
            |:...|.:..|:        ||:...::.:   :..:|.|             |....|.|....
Mouse  1108 GAPLTDDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHV 1172

  Fly   135 RVVGEKTKKKPASGSSSPSKAKTTSEDSLA-KTSISSESSPEKTSKIKTTAAKISKPGSEKAPRA 198
            |.|.|..:......:...|..:.|.:.::. ::::.|..:|.....::..:.::::..|::|.|.
Mouse  1173 RAVAEACQPGVEGVNPMTSVNQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASRY 1237

  Fly   199 SPEEC-----------------------PELSTEINSKNTSSESP------VAKKTAKVTSK--- 231
            .|:.|                       .|..|:|..|..:...|      |..:..:|.:.
Mouse  1238 MPDICVIRAIQKIIWTSGCGGLQLVFSPNEEVTKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFA 1302

  Fly   232 --PT-LELLSPIKP-------------SSPIKELDCEP-------------------------VD 255
              || |:.||..|.             |..::::..|.                         :.
Mouse  1303 LIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLG 1367

  Fly   256 TLSKQQLSEQLQLYPQGRNLISPVDDAPSDLFISDAEQLSDDDLALGASASPTMLGPGYDYGAPT 320
            :.::::.......:...|:|::...:  |::.:.:||.|.::::        ..|....|....|
Mouse  1368 STARERAKHSGDYFTLLRHLLNYAYN--SNINVPNAEVLLNNEI--------DWLKRIRDDVKRT 1422

  Fly   321 GDSDV-----EGVTGVT-------DPST---IG------------TDDGTYPALSNFYRRKYGGD 358
            |::.|     ||..|||       .|..   ||            .||..:|| ||.|.:.....
Mouse  1423 GETGVEETILEGHLGVTKELLAFQTPEKKFHIGCEKGGANLIKELIDDFIFPA-SNVYLQYMRNG 1486

  Fly   359 ELRAWQRVNTTGAD--------------------------------FVSSATTETEAEARQASL- 390
            ||.|.|.:...|:.                                ::.:|.|..||......|
Mouse  1487 ELPAEQAIPVCGSPATINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLP 1551

  Fly   391 --GPR---GYVGLVNQAMTCYLNSLLQALFMTPEFRNAL-------------------------- 424
              |||   |:|||.|...|||:||::|.|:|.|..||.:
Mouse  1552 PVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNV 1616

  Fly   425 --------YRWEFDN--------DNEAKNIPY--QLQKLFLNLQTSPKAAVETTDLTRSFGWDST 471
                    |..:|::        |.:..||..  .||.:|.:|..|.....    :.|.| |...
Mouse  1617 DPRDDVFGYPQQFEDKPPLSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYY----VPRGF-WKQF 1676

  Fly   472 EAW-------QQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDT 529
            ..|       :|||..|....:.|:|:...|......::|.:..|...|...|..|......|::
Mouse  1677 RLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEES 1741

  Fly   530 FLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTL 594
            |..:.:.:|      .:.::.::|..:|:.:.|:|.|.|.||||.||.|..|.|..|..|.:|.:
Mouse  1742 FTTLNVDIR------NHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAI 1800

  Fly   595 HLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDD 659
            .|||||:|::....||.||...||:.|::..:                      |....:.:|.|
Mouse  1801 QLKRFDYDWERECAIKFNDYFEFPRELDMEPY----------------------TVAGVAKLEGD 1843

  Fly   660 NLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAY 724
            |::.           |:.|..::|       .|:|.|.||..  |.|..:::|||.|||||||:|
Mouse  1844 NVNP-----------ESQLIQQNE-------QSESEKAGSTK--YRLVGVLVHSGQASGGHYYSY 1888

  Fly   725 I-----KDFDNNEWFCFNDQNVTSITQEDIQ----RSFGGPNGSYYSSAYTSST----------- 769
            |     .|.:.|.|:.|:|.:||....:|.:    :.||   |.|....:....
Mouse  1889 IIQRNGGDGEKNRWYKFDDGDVTECKMDDDEEMKNQCFG---GEYMGEVFDHMMKRMSYRRQKRW 1950

  Fly   770 -NAYMLMYRQVD--AKRNELVAKVAD-----------FPEHIKTLLPK-----LHSE-------- 807
             |||:|.|.::|  ...:|::..:::           .|..|:..:.|     :|:.
Mouse  1951 WNAYILFYERMDTIGHDDEVIRYISEIAITTRPHQIVMPSAIERSVRKQNVQFMHNRMQYSLEYF 2015

  Fly   808 ------------------EETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKMKITRVYVSQS 854
                              .:..:|.....||:..:.|     ...:.:.......||.|...|..
Mouse  2016 QFMKKLLTCNGVYLNPPPGQDHLSPEAEEITMISIQL-----AARFLFTTGFHTKKIVRGSASDW 2075

  Fly   855 FNINLVLMSAYEMLNVE-QFAPLSRCRLVAYNSSMDTIIQSLESCTDPALTELRAAQNYSLDFLL 918
            ::...:|:.  ...||. .||     ..|.:|.| :...:.|..|..   .|:|.|....:.|:.
Mouse  2076 YDALCILLR--HSKNVRFWFA-----HNVLFNVS-NRFSEYLLECPS---AEVRGAFAKLIVFIA 2129

  Fly   919 EYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAARER-EASDVLRRSI--ALRLHISE 980
            .:..:|....                |..|..||   .|.|.:. ..||.|.|::  .||..:||
Mouse  2130 HFSLQDGPCP----------------SPFASPGP---SSQAYDNLSLSDHLLRAVLNLLRREVSE 2175

  Fly   981 -----QQFL--------------LATVRATVPKAF--VSYDPHPTPEALQHLQNMANTQFKSITY 1024
                 ||:.              ...::.:||..|  ||.|..|.|               .|.|
Mouse  2176 HGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGP---------------PIKY 2225

  Fly  1025 FYLNVPNTDAATLEMLGVPTVESVECASGGDVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVEP- 1088
            .|        |.|..|.....:.:.|.:    |.:.|.:.: .|:.|..|.:.         :|
Mouse  2226 QY--------AELGKLYSVVSQLIRCCN----VSSRMQSSI-NGNPSLPNPFG---------DPN 2268

  Fly  1089 MSQP-SPSHGH------------ESNSEDSSLSDGDRTLVE---TDNMAHRGGGDSQVSSTSHSP 1137
            :||| .|...:            :...||.|.||....|:.   .:|        .|.|||..|.
Mouse  2269 LSQPIMPIQQNVVDILFVRTSYVKKIIEDCSNSDETVKLLRFCCWEN--------PQFSSTVLSE 2325

  Fly  1138 ---------------------QLSSPEDEAASHDAMMRVHAYCNGNGSYAAADVVDPLL--LPTS 1179
                                 |:...||...:|    |:|     |......|..|.|.  :..|
Mouse  2326 LLWQVAYSYTYELRPYLDLLLQILLIEDSWQTH----RIH-----NALKGIPDDRDGLFDTIQRS 2381

  Fly  1180 TNHFFYATKVECVD-VVGTGSSSGHQSDEEAQLRKPTRAYKLLVGTHMRMGAFKKH----IEQLI 1239
            .|| :.....:|:. :|...||.            |. ||::|.|.    |..|:.    :|.|.
Mouse  2382 KNH-YQKRAYQCIKCMVALFSSC------------PV-AYQILQGN----GDLKRKWTWAVEWLG 2428

  Fly  1240 QVPAAHFKLQRK--------HDNNLS----NNQNNSLVHLIEGETLTVELGKTLE--PDEFKAKI 1290
            .      :|:|:        ..||.|    :|:.::...|....:..:.|.|..|  |:|.|..
Mouse  2429 D------ELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEVKKA- 2486

  Fly  1291 HFLRLADIDNETSKLP 1306
              ..|.:|:.|.||.|
Mouse  2487 --TSLQEIEMEESKEP 2500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066	30/188 (16%)
		peptidase_C19C	394..780	CDD:239124	119/457 (26%)
		USP47_C	1300..1534	CDD:466158	4/7 (57%)
Usp9x	XP_006527649.1	Ubl1_cv_Nsp3_N-like	<905..969	CDD:475130
		peptidase_C19C	1560..1963	CDD:239124	119/458 (26%)
		DUF3517	2102..2481	CDD:463438	97/479 (20%)