Protein Alignment Blimp-1 and PRDM6

DIOPT Version :10

• Sequence 1: NP_001261442.1
• Gene: Blimp-1 / 38638
• FlyBaseID: FBgn0035625
• Length: 1216
• Species: Drosophila melanogaster
• Sequence 2: NP_001129711.1
• Gene: PRDM6 / 93166
• HGNCID: 9350
• Length: 595
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 154/739 - (20%)
• Similarity: 243/739 - (32%)
• Gaps: 253/739 - (34%)

  Fly   331 GNGPANGSVAGSVSGA----TPPPPTATPCCRRSSPPAHVSTTTSTCNAHHPHIQHGRHASVIIG 391
            |.||..||.|..:..|    .||||...|  .|:.||
Human    31 GAGPLKGSGAAGLLSAPQPLQPPPPPPPP--ERAEPP---------------------------- 65

  Fly   392 QDRSPMASSDKDTAGSPLSGLDHQMTPQDGSVRSVRSDEGYHSNECHEDGLTPPEDSSDSESEHN 456
                                 ...:.|:..|:.|..|              ||...|:.:.|
Human    66 ---------------------PDSLRPRPASLSSASS--------------TPASSSTSASS--- 92

  Fly   457 YVLDCSKKAIAPKETVIAQAQKPSSSPPAVVMANTTTNSMISHSSPTATPICETDKNEYRKFKVK 521
                               |...:::..|..:|..           :|.|:.:        ..|.
Human    93 -------------------ASSCAAAAAAAALAGL-----------SALPVSQ--------LPVF 119

  Fly   522 MPLKYEFKNKTCVKQEPSLKEVDQEMSLPQEEEEDQVMHPEPDSICPSTTTHL-----------G 575
            .||.     ...|..||          ||            |..:|...|:..           |
Human   120 APLA-----AAAVAAEP----------LP------------PKELCLGATSGPGPVKCGGGGGGG 157

  Fly   576 DEHMLMMERERERERERIQEREPSNQQPASSTVIVLEHNSGGQAR-TIVPLSKPYYEPDPPGERY 639
            .|       .|...|.|....|             |::...||.| .|:||::  :..||.....
Human   158 GE-------GRGAPRFRCSAEE-------------LDYYLYGQQRMEIIPLNQ--HTSDPNNRCD 200

  Fly   640 M----RFGQ-PSSSILETILTSQHRLEAAAAAANACRQANAATPPPTSP---------------- 683
            |    |.|: |....|.::    .||...::||       ||.|||..|
Human   201 MCADNRNGECPMHGPLHSL----RRLVGTSSAA-------AAAPPPELPEWLRDLPREVCLCTST 254

  Fly   684 -TEMAYSYKKSQR--YGNAVSPDSSSNLGQNPEQLSSSAV-------VVGEQEMTRATMIKGECS 738
             ..:||....:||  .|..:.|.....|  .||::.:.||       .:.:|:.|....|.|
Human   255 VPGLAYGICAAQRIQQGTWIGPFQGVLL--PPEKVQAGAVRNTQHLWEIYDQDGTLQHFIDG--- 314

  Fly   739 PPPPSHHHHNVIFSPSRHAAYLGAGEAGGHSPSPGYPGYPHYGA-------AATSTFHSPPHSSH 796
             ..||..........:||     .||.  :.....|.....|.|       .....:::..::|.
Human   315 -GEPSKSSWMRYIRCARH-----CGEQ--NLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSF 371

  Fly   797 SPFDRQSNASSGAGSATNLHLLQTSTQ-MLNHPLMQPLTPLQRLSPLR-----ISPPSSLSPDGN 855
            .....|..|..     .||::..|..: |.....:||.....:|:|..     :.|.:..|.:.:
Human   372 FGIPLQCIAQD-----ENLNVPSTVMEAMCRQDALQPFNKSSKLAPTTQQRSVVFPQTPCSRNFS 431

  Fly   856 SCPRSGSPLSP--NSLASRGYRSLPYP-----LKKKDGKMH-YECNVCCKTFGQLSNLKVHLRTH 912
            ...:|| |:..  |.:..:..|.|..|     |..:....| ::|..|.|||.|...|::|:.|.
Human   432 LLDKSG-PIESGFNQINVKNQRVLASPTSTSQLHSEFSDWHLWKCGQCFKTFTQRILLQMHVCTQ 495

  Fly   913 SGERPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLRLHSGQKPYACD 977
            :.:||::|..|::||:|.:.|:.|.:.|:.::|.:|..|.:.|:..:.|..|:|.|:|:||:.|:
Human   496 NPDRPYQCGHCSQSFSQPSELRNHVVTHSSDRPFKCGYCGRAFAGATTLNNHIRTHTGEKPFKCE 560

  Fly   978 LCPQKFTQFVHLKLHKRLHTNDRP 1001
            .|.:.|||...|..|:|:....:|
Human   561 RCERSFTQATQLSRHQRMPNECKP 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	PR-SET_PRDM1	120..262	CDD:380964
		zf-C2HE	<871..912	CDD:465082	13/46 (28%)
		C2H2 Zn finger	892..912	CDD:275368	8/19 (42%)
		zf-H2C2_2	904..929	CDD:463886	9/24 (38%)
		C2H2 Zn finger	920..940	CDD:275368	7/19 (37%)
		SFP1	<938..1020	CDD:227516	21/64 (33%)
		C2H2 Zn finger	948..968	CDD:275368	6/19 (32%)
		C2H2 Zn finger	976..996	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1004..1023	CDD:275368
PRDM6	NP_001129711.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..90		22/123 (18%)
		PR-SET_PRDM6	244..372	CDD:380968	25/140 (18%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		SUF4-like	527..594	CDD:411020	20/58 (34%)
		C2H2 Zn finger	531..552	CDD:411020	6/20 (30%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		zf-H2C2_2	544..568	CDD:463886	10/23 (43%)
		C2H2 Zn finger	559..577	CDD:275368	7/17 (41%)