Protein Alignment Blimp-1 and prdm2b

DIOPT Version :10

• Sequence 1: NP_001261442.1
• Gene: Blimp-1 / 38638
• FlyBaseID: FBgn0035625
• Length: 1216
• Species: Drosophila melanogaster
• Sequence 2: XP_002663834.2
• Gene: prdm2b / 797296
• ZFINID: ZDB-GENE-080613-3
• Length: 1792
• Species: Danio rerio
• Alignment Length: 1532
• Identity: 305/1532 - (19%)
• Similarity: 480/1532 - (31%)
• Gaps: 543/1532 - (35%)

  Fly   114 LPNRADKTLPRSLTLKSSMVYSTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYPNDKNKAR--- 175
            :|....|.||.|:.|:.|.|    |....|||:|.:||:|.|||||.|         :.|.|
Zfish    14 IPAHVWKGLPNSMKLEPSAV----NPSRIGVWASRLIPKGKRFGPFVG---------ERKKRSQV 65

  Fly   176 ----YFWRVQGTRHITYGNIKIFKDDDYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENI 236
                |.|.|            .|....:..:|.:|..:.||:|||..|.|....||...:....|
Zfish    66 TSNVYMWEV------------YFPAWGWMCVDATDPMKGNWLRYVNWARSSQEQNLFPLEINRAI 118

  Fly   237 YFYTTRDILPNEELMVWYC------------KDFASRLGYDVDP-------------------ET 270
            |:...|.|.|:|||:|||.            ::..|.|.....|                   :|
Zfish   119 YYKVLRPIGPDEELLVWYNGEDNPEIAAALEEERTSNLNKKSSPRAKRARRSLKSKELSEKSRQT 183

  Fly   271 TIFGAC--KQAVEAEEEADEEEEEAEGEDGKPRYSMPAPEIPPDVAV-------------SHITY 320
            .:.|.|  |:...:|....|..:..||.:|:...|.|: |:..:.||             ||.|.
Zfish   184 DLGGFCEPKKLSASEPSITEMRDSEEGLNGEEGPSSPS-ELQQENAVSQALSTENENPVQSHATE 247

  Fly   321 V---MGLHLPVGAGNG----------PANGSVAGSVSG--------------------------- 345
            :   .||:......:|          |.:.|.|.||.|
Zfish   248 MNRWEGLNEENTEADGQLQQPQLNQSPQHPSEAESVEGNEKSLLQSHSGSPAEESSESPLCDTDC 312

  Fly   346 ----ATP-----------PPPTATPC--CRRS-------SPPAHVSTTTSTCNAHHPHIQHGRHA 386
                |.|           |.....||  |.|.       ....|:.||::    |..|....|:.
Zfish   313 ISSLANPELEAEGDFEDDPQGETYPCQHCERHFSTKQGLERHTHIHTTSN----HQTHTFKCRYC 373

  Fly   387 SVIIG--------QDRSPMASSDKDTAGSPLSGLDHQMTPQDGSVRSVRSDEGYHSNECH----- 438
            :...|        :.|....|...:..|| |||.....:|   :|.:..:..|..|:..|
Zfish   374 AKPFGSQVGRRRHERRHENGSKTLNRPGS-LSGTSFLPSP---TVANDSATSGSVSSPSHSVVIS 434

  Fly   439 -EDGLTPPEDSSDS-------ESEHNYVLD-------------CSK-----------------KA 465
             ::|  ||:.:|:|       ||:..:::|             |:|                 :.
Zfish   435 TQNG--PPQQTSESLKKEPGAESDRPFIVDENGESKELHPCKYCNKAFGTHTNMRRHQRRIHERH 497

  Fly   466 IAPK----------------------ETVIAQAQKPSSSPPAVVMANTTT--------------- 493
            :.||                      :||..|.:.||:|||.:.:.:..|
Zfish   498 LMPKGVRRKGMLLQESSSQQHQHEQGQTVSLQEESPSASPPPIYVPSVETEDEGEREECMVDISN 562

  Fly   494 --NSMISH---------SSPTATPICETDKNEYRKF----------KVKMPLKYE-----FKNKT 532
              :..:||         |:.:...:.|.|.|....|          ::...||.|     .|..:
Zfish   563 NISENLSHYIDGKIPSTSTVSNCEVIEVDSNTAALFGLDTLILSPKQIGHALKVETRTCPAKEVS 627

  Fly   533 CVKQEPSLKEVDQEMSLPQEEEEDQVMHPEPDSICPSTTTHL-------GDEHMLMMERER---- 586
            ||.|....:.......||..:.|.:..........||:.:.|       .....|...:|:
Zfish   628 CVTQATQRRRTATPPLLPGVKVEAETASSSSSLSSPSSQSSLLVGNIFSQSTETLAFPKEKTVYL 692

  Fly   587 -ERERERIQEREPSNQQPASSTVIVLEHNSGGQARTIVPLSKPYYEPDPPGERYMRFGQPSSSIL 650
             .:.::.:|  .|..|:||...:.        .:|...|||.... |...|:...|...|.::..
Zfish   693 SPKLKQLLQ--APDGQKPAIGLIT--------DSRLTTPLSVTSL-PAVQGKFKRRTASPPTTSQ 746

  Fly   651 ETILTSQHRLEAAAAAANACR----QANAATPPPTSPTE--------MAYSYKKSQRYGNAVSP- 702
            .:  ..|......:|....|.    :..:.|...|||::        ....:..|:..||:.:.
Zfish   747 NS--PPQRNDNTNSATGVTCSLKVPKMESVTDSWTSPSKDHGDTESLTGKDWSPSRSGGNSCNQQ 809

  Fly   703 --DSSSNLGQNPEQLS-SSAVVVGEQEMTRATMI-----KGECSPPP------------------ 741
              |.|::..:..:.:| .|...|.:..|:|.:.:     .|..:.||
Zfish   810 PLDLSNSFSKRDDSISRGSGEAVLDLSMSRKSPVDHEVKTGSATLPPHVKRKKPNTSILEKVLMN 874

  Fly   742 -------PSHHHHNVIFSPSRHAAYLGAGEAGGHSPSPGYPGYPHYGAAATSTFHSPPHSSHSPF 799
                   |.....|.:.||...::...|......||..|....|     ..||  |||..:....
Zfish   875 EYAGLNSPGEEESNTVGSPDAFSSSESATCVAPSSPGSGSERLP-----CEST--SPPSLTLMTI 932

  Fly   800 DRQSNASSGAGSATN----LHLLQTSTQM--LNHPLMQPLT--PLQRLSPLRISPP--------- 847
            :..|.:||...|:|.    |..:.:...:  .:.||...||  |...||| ::||.
Zfish   933 NPSSPSSSSIASSTPPPPVLPTIPSPPPLSSKHFPLSDALTPSPFPVLSP-KMSPKAVDSLEDVS 996

  Fly   848 -------------SSLSPDGNS-------------------CPRSGSPLSPNSLASRGYRSLPYP 880
                         :|:..:.|.                   |....|..|...|....:.|.|..
Zfish   997 DSSALTEPCHDALNSIVSESNQTAEQLDSVNSPLPQDAKRHCTADSSSKSETLLEGSTHDSKPQF 1061

  Fly   881 LKKKD--GKMHYECNV---------CCKTFGQLSNLKVHLR------------------------ 910
            ||..|  |..|.|.:.         |..|..|..|.|..:|
Zfish  1062 LKTADQAGSSHLEWDTSSESNQSHSCEGTLPQDLNNKTEVRQKSKSPLSTVQSTPKKESSSPNFL 1126

  Fly   911 --THSGER---------------------------------------------------PFKCNV 922
              .||.:|                                                   .|.|||
Zfish  1127 SKLHSPQRSSEADDNLIIEDVRKKEEMVDITANGADVSPGTSVRSSDEVDSAERETFVKSFVCNV 1191

  Fly   923 CTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTH-LRLHSGQKPYACDLCPQKFTQF 986
            |.:.|..:..|..|.:.|..|.|.:|:.|.:.|.:.:.|..| ..||...:.|.|.:|.::|...
Zfish  1192 CKEPFRSIKDLSGHIIEHASEWPFKCEFCVQLFGNATALLEHRSSLHGVGRIYVCSICSKEFAFL 1256

  Fly   987 VHLKLHKR-LHTNDRPYVCQGCDKKYISASGLR-THWKTTSCKPNNLEEE--LAMAAAATSECLD 1047
            .:|:.|:. ||.:      |.|....:....|| .::...:|.  |:|::  |...|.|.||...
Zfish  1257 CNLQQHQSDLHPS------QSCTHTAVENGKLRPQNYTNPACA--NIEKDAVLDSTAGAPSENSS 1313

  Fly  1048 KDHPEPDSREAYEQLTQHMHPA--VHPGLRHLSSGGQSP--PRLIPLGNHMAPQQQSHQQQQQQH 1108
            ::| ..|:.:..|:...|..|.  ::..::.::|....|  |. :.||.:             ||
Zfish  1314 EEH-NNDTNKVEEEEGGHEDPTEELYTTIKIMASEAGKPKGPD-VRLGIN-------------QH 1363

  Fly  1109 QQQGVPPP---HLLMTQHSVGPA--------PMLLTTA-------SQLPPPPPHHQQ-----NSP 1150
            .....|||   |......||..|        |...:||       :.....|..|:.     |:.
Zfish  1364 YPSFKPPPFPYHNRSPDGSVASATNFTTHNIPQTFSTAIRCTKCGNSFDNMPELHKHILVCANAS 1428

  Fly  1151 SRLLQHGHAHPLQMQQQQQQQQQHSPKGLKSL-PESG 1186
            .:.......:|:.::|..:|    ||.|:... |.:|
Zfish  1429 DKRRYTPKKNPIPLKQVVKQ----SPNGISPTGPSTG 1461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	PR-SET_PRDM1	120..262	CDD:380964	50/160 (31%)
		zf-C2HE	<871..912	CDD:465082	14/77 (18%)
		C2H2 Zn finger	892..912	CDD:275368	6/54 (11%)
		zf-H2C2_2	904..929	CDD:463886	12/101 (12%)
		C2H2 Zn finger	920..940	CDD:275368	7/19 (37%)
		SFP1	<938..1020	CDD:227516	22/84 (26%)
		C2H2 Zn finger	948..968	CDD:275368	5/20 (25%)
		C2H2 Zn finger	976..996	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1004..1023	CDD:275368	4/19 (21%)
prdm2b	XP_002663834.2	PR-SET_PRDM2	19..141	CDD:380965	49/146 (34%)
		C2H2 Zn finger	338..358	CDD:275370	4/19 (21%)
		C2H2 Zn finger	473..494	CDD:275368	2/20 (10%)
		C2H2 Zn finger	1189..1209	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1217..1238	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1246..1263	CDD:275368	4/16 (25%)