DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and Prdm5

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	XP_006506667.1	Gene:	Prdm5 / 70779	MGIID:	1918029	Length:	630	Species:	Mus musculus

Alignment Length:	971	Identity:	182/971 - (18%)
Similarity:	303/971 - (31%)	Gaps:	377/971 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 LPRSLTLKSSMVYSTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYPNDKNK---ARYFWRVQGT 183
            :|....||||.|..     ..|::::..:.:|.:||||.|  ....|.|.::   .|..|.|:|:
Mouse     6 VPDRFALKSSRVQD-----GMGLYTARRVRKGEKFGPFAG--EKRMPEDLDENMDYRLMWEVRGS 63

  Fly   184 RHITYGNIKIFKDDDYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNE 248
                       |.:..|.||.::...|||:|:|..|.|....||.|.|..|||::....||..:.
Mouse    64 -----------KGEVLYILDATNPRHSNWLRFVHEAPSQERKNLAAIQEGENIFYLAVDDIETDT 117

  Fly   249 ELMVWYCKDFASRLGYDVDPETTIFGACKQAVEAEEEADEEEEEA--EGEDGKPRYSMPAPEIPP 311
            ||::.|                         ::::.||:|||::|  ..::||
Mouse   118 ELLIGY-------------------------LDSDVEAEEEEQQALTMTKEGK------------ 145

  Fly   312 DVAVSHITYVMGLHLPVGAGNGPANGSV-AGSVSGATPPPPTATPCCRRSSPPAHVSTTTSTCNA 375
               |.|                 :.|.: |||..........|.|.|..|.|...|.|
Mouse   146 ---VDH-----------------SKGQLAAGSKGHLGCEEDFACPQCESSFPSEEVLT------- 183

  Fly   376 HHPHIQHGRHASVIIGQDRSPMASSDKDTAGSPLSGLDHQMTPQDGSVRSVRSDEGYHSNECHED 440
                 :|                          |..|..:.|             |....:|...
Mouse   184 -----EH--------------------------LQSLHQKPT-------------GEKEFKCENC 204

  Fly   441 GLTPPEDSSDSESEHNYVLDCSKKAIAPKETVIAQAQKPSSSPPAVVMANTTTNSMISHSSPTAT 505
            |...|.    .::...:.|.|:.::          :.|.|||.....:.|:..:|.:|.
Mouse   205 GKKFPV----RQALQRHALFCTARS----------SLKNSSSSVQCALCNSLFSSALSF------ 249

  Fly   506 PICETDKNEYRKFKVKMPLKYEFKNKTCVKQEPSLKEVDQEMSLPQEEEEDQVMHPEPDSICPST 570
                   .::|| ..:...::..|..:|.|:   ||..|   :|.:.:|......|:...||...
Mouse   250 -------EQHRK-ACRGEARFVCKADSCGKR---LKSKD---ALRRHQENVHTGDPKRKLICSVC 300

  Fly   571 TTHLGDEHMLMMERERERERERIQEREPSNQQPASSTVIVLEHNSGGQARTIVPLSKPYYEPDPP 635
                                          .:..:|...:.||..
Mouse   301 ------------------------------NRKCTSVSSLQEHRK-------------------- 315

  Fly   636 GERYMRFGQPSSSILETILTSQHRLEAAAAAANACRQANAATPPPTSPTEMAYSYKKSQRYGNAV 700
                          :..|...|..::...:|....|.              ..::.:.:.|...:
Mouse   316 --------------IHEIFDCQECMKKFISANQLKRH--------------MITHSEKRPYNCEI 352

  Fly   701 SPDSSSNLGQNPEQLSSSAVVVGEQEMTRATMIKGECSPPPPSHHHHNVIFSPSRHAAYLGAGEA 765
            ...|...|.|           ||.                      |.||
Mouse   353 CNKSFKRLDQ-----------VGA----------------------HKVI--------------- 369

  Fly   766 GGHSPSPGY------PGYPHYGAAATSTFHSPPHSSHSPFDRQSNASSGAGSATNLHLLQTSTQM 824
              ||....|      .|:.|......   |...||...||  |.:|...        |.:|...:
Mouse   370 --HSEDKPYQCKLCGKGFAHRNVYKN---HKKTHSEERPF--QCDACKA--------LFRTPFSL 419

  Fly   825 LNHPLMQPLTPLQRLSPLRISPPSSLSPDGNSCPRSGSPLSPNSLASRGYRSLPYPLKKKDGKMH 889
            ..|.|:.                                                     :.:..
Mouse   420 QRHLLIH-----------------------------------------------------NSERT 431

  Fly   890 YECNVCCKTFGQLSNLKVHLR-THSGERPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKK 953
            ::|:.|..||.:...|.||:: .|...:.::|.:|.|:|...:.|:.|...|||||...|..|.:
Mouse   432 FKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHKKTHTGEKEKVCPYCGQ 496

  Fly   954 RFSSTSNLKTHLRLHSGQKPYACDLCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISASGLR 1018
            :|:|:..|:.|:|.|:|::||.|..|.:.|::...||:|.|.||.::||.|..|.|.:....||.
Mouse   497 KFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKPYQCSECSKAFSQKRGLD 561

  Fly  1019 THWKT-TSCKPNNLEEELAMAAAATSECL-------DKDHPEPDSREAYEQLTQHMHPAVH 1071
            .|.:| |..||  .:.::...|.:..:.|       :.:.|..:....:::.|::.:..||
Mouse   562 EHKRTHTGEKP--FQCDVCDLAFSLKKMLIRHKMTHNPNRPMAECHFCHKKFTRNDYLKVH 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	37/129 (29%)
		C2H2 Zn finger	892..912	CDD:275368	7/20 (35%)
		zf-H2C2_2	904..929	CDD:290200	8/25 (32%)
		C2H2 Zn finger	920..940	CDD:275368	6/19 (32%)
		zf-H2C2_2	932..957	CDD:290200	10/24 (42%)
		C2H2 Zn finger	948..968	CDD:275368	7/19 (37%)
		zf-H2C2_2	960..985	CDD:290200	10/24 (42%)
		C2H2 Zn finger	976..996	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1004..1023	CDD:275368	6/18 (33%)
Prdm5	XP_006506667.1	PR-SET_PRDM5	2..128	CDD:380967	42/164 (26%)
		C2H2 Zn finger	169..190	CDD:275368	8/58 (14%)
		zf-C2H2_8	<172..222	CDD:374215	14/104 (13%)
		C2H2 Zn finger	201..217	CDD:275368	3/19 (16%)
		C2H2 Zn finger	236..256	CDD:275368	5/33 (15%)
		COG5048	258..621	CDD:227381	100/565 (18%)
		C2H2 Zn finger	264..287	CDD:275368	8/28 (29%)
		C2H2 Zn finger	297..317	CDD:275368	4/83 (5%)
		C2H2 Zn finger	322..342	CDD:275368	3/33 (9%)
		C2H2 Zn finger	350..370	CDD:275368	8/69 (12%)
		C2H2 Zn finger	378..398	CDD:275368	3/22 (14%)
		C2H2 Zn finger	406..426	CDD:275368	5/27 (19%)
		C2H2 Zn finger	434..455	CDD:275368	7/20 (35%)
		C2H2 Zn finger	463..483	CDD:275368	6/19 (32%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	519..539	CDD:275368	7/19 (37%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		C2H2 Zn finger	575..595	CDD:275368	2/19 (11%)
		C2H2 Zn finger	604..625	CDD:275368	3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2461
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810