DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and wor

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	NP_476601.1	Gene:	wor / 34906	FlyBaseID:	FBgn0001983	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	614	Identity:	129/614 - (21%)
Similarity:	213/614 - (34%)	Gaps:	177/614 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   593 IQEREPSNQQPASSTVIVLEHNSG----GQARTIVPLSKPYY----EPDP---PGERYMRFGQPS 646
            ::|..|.:.         |.|:.|    ..|...||: :|::    ||:|   |.|...||
  Fly    18 VEESSPEDH---------LSHDEGPVDLSVASAAVPM-EPHWMAKSEPEPQPVPTELRRRF---- 68

  Fly   647 SSILETILTSQHRLEAAAAAANACRQANAATPPPTSPTEMAYSYKKSQRYGNAVSPDSSSNLGQN 711
                 ....:|.:.:.|.......|:...|.|...:..|:|.|..: ..||....|.....:...
  Fly    69 -----DAAMNQTKEQLARRIWEETREIARAFPDVFTREEIAKSLAR-LGYGEFELPPEEEVMEPE 127

  Fly   712 PEQLSSSAVVVGEQEM----TR---ATMIKGECSPP---PPSHHHHNVIFSPSRHAAYL---GAG 763
            ||.         ||.:    ||   .|:||.|.|..   |..::::|::.|.:.:...:   ...
  Fly   128 PEP---------EQHLPLRYTRDASPTIIKAEPSDEEQFPLRNYNNNLLKSIAEYEDCMKMQNIK 183

  Fly   764 EAGGHSPSPGYPGYPHYGAAATSTFHSPPHSSHSPFDRQSNASSGAGSATNLHLLQTSTQMLNHP 828
            |.....|||             ..|:.||.....|.|.         |.|...:|..:..:.|
  Fly   184 EEIPPIPSP-------------QLFYPPPTPLAEPEDL---------SVTQRRVLSENMNLQN-- 224

  Fly   829 LMQPLTPLQRLSPLRISPPSSLSPDG-----------------------NSCPRSGSPLSPNSLA 870
            :.:.|..:|.::|....||..:..|.                       |.|..:.:.|..:. .
  Fly   225 VARALLSMQHMAPQHAPPPIDMEEDQENQDINQLKIKSSNDLYYQCQQCNKCYATYAGLVKHQ-Q 288

  Fly   871 SRGYRSLPY-------------------------------------PLKKKDGKMHYECNVCCKT 898
            :..|.|..|                                     .::|..|...|.|..|.|:
  Fly   289 THAYESTEYKIIRSQPGGSGAIVDQTEFCTDQASALIQAANVASAQSMQKPVGVPRYHCQDCGKS 353

  Fly   899 FGQLSNLKVHLRTH--SGE-----RPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFS 956
            :...|.|..|.:.|  |.|     :.|.|..|.|::..|..|:.|...||  .|.:|.||.|.||
  Fly   354 YSTYSGLSKHQQFHCPSAEGNQVKKVFSCKNCDKTYVSLGALKMHIRTHT--LPCKCPICGKAFS 416

  Fly   957 STSNLKTHLRLHSGQKPYACDLCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISASGLRTHW 1021
            ....|:.|:|.|:|:||::|..|.:.|....:|:.|.:.|::.:.|.|..|.|.:...|.|..|.
  Fly   417 RPWLLQGHIRTHTGEKPFSCQHCNRAFADRSNLRAHMQTHSDVKKYSCPTCTKSFSRMSLLAKHL 481

  Fly  1022 KTTSCKPNNLEEELAMAAAATSECLDKDHPEPDSREAYEQLTQHMHPAVHPGLRHLSSGGQSPPR 1086
            : :.|     :.|.:...:.:....|:           :||.||:         .:...|.:|.:
  Fly   482 Q-SGC-----QTEQSGGPSGSGGGFDQ-----------QQLQQHL---------QVYEEGHNPHQ 520

  Fly  1087 LIPLGNHMAPQQQSHQQQQQQHQQQGVPP 1115
            |...|:  .......:::..::|.|  ||
  Fly   521 LYYAGS--VGSSNGEEEEGGEYQMQ--PP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614
		C2H2 Zn finger	892..912	CDD:275368	6/19 (32%)
		zf-H2C2_2	904..929	CDD:290200	9/31 (29%)
		C2H2 Zn finger	920..940	CDD:275368	6/19 (32%)
		zf-H2C2_2	932..957	CDD:290200	10/24 (42%)
		C2H2 Zn finger	948..968	CDD:275368	9/19 (47%)
		zf-H2C2_2	960..985	CDD:290200	10/24 (42%)
		C2H2 Zn finger	976..996	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1004..1023	CDD:275368	6/18 (33%)
wor	NP_476601.1	C2H2 Zn finger	270..290	CDD:275368	3/20 (15%)
		C2H2 Zn finger	317..334	CDD:275368	0/16 (0%)
		zf-C2H2	345..367	CDD:278523	7/21 (33%)
		C2H2 Zn finger	347..367	CDD:275368	6/19 (32%)
		PHA00732	379..>417	CDD:177300	15/39 (38%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		zf-C2H2_8	405..482	CDD:292531	27/76 (36%)
		zf-C2H2	406..428	CDD:278523	9/21 (43%)
		C2H2 Zn finger	408..428	CDD:275368	9/19 (47%)
		zf-H2C2_2	421..444	CDD:290200	9/22 (41%)
		zf-C2H2	434..456	CDD:278523	5/21 (24%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		zf-H2C2_2	448..473	CDD:290200	7/24 (29%)
		C2H2 Zn finger	464..481	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457157
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930