DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and prdm1a

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	NP_955809.2	Gene:	prdm1a / 323473	ZFINID:	ZDB-GENE-030131-2193	Length:	776	Species:	Danio rerio

Alignment Length:	1058	Identity:	312/1058 - (29%)
Similarity:	414/1058 - (39%)	Gaps:	364/1058 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 QDYDVTRMREEDFERLAVYLVPDVQAERGLPN----RADKTLPRSLTLKSSMVYSTPNVKTEGVW 145
            :|.|:|:..|::||....|:|.|...|..|.|    ||:.:|||:|..|    :...:.:..||.
Zfish    37 EDVDMTKWTEDEFEEKCTYIVKDHTWEGPLENTDLTRAEASLPRNLAFK----HPADSKEVIGVV 97

  Fly   146 SSGVIPRGTRFGPF--EGIPTSNYPNDKNKARYFWRVQGTRHITYGNIKIFKDDDY-YYLDGSDR 207
            |...||:||||||.  |.....|.|.|.|: :||||             |:.|.:: :::||.|.
Zfish    98 SREYIPKGTRFGPLVGESYTAENVPKDANR-KYFWR-------------IYSDGEFHHFVDGLDE 148

  Fly   208 SQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLGYDVDPETTI 272
            .:|||||||..|:|....||.|||:..||||||.:.|..::||:||||.:||.||.|....|..:
Zfish   149 EKSNWMRYVNPAHSQQEQNLAACQNGMNIYFYTVKAIPADQELLVWYCPEFARRLNYPASGEIMM 213

  Fly   273 FGACKQAVEAEEEADEEEEEAEGEDGKPRYSMPAPEIPPDVAVSHITYVMGLHLPVGAGNGPANG 337
            ....:..:||:::|.|.:...:.|..       ..||..||          |..|
Zfish   214 QKLKQSLIEAKQQATEVKHPVKREHS-------VSEILKDV----------LQEP---------- 251

  Fly   338 SVAGSVSGATPPPPTATPCCRRSSPPAHVSTTTSTCNAHHPHIQHGRHASVIIGQDRSPMASSDK 402
                     :.|.||...|.:....|.:.|       |.:|                 |..|.::
Zfish   252 ---------SRPLPTRPRCPKSPDRPLYPS-------AVYP-----------------PRPSLNE 283

  Fly   403 D-TAGSPLSGLDHQMTPQDGSVRSVRSDEGYHSNECHEDGLTPPEDSSDSESEHNYVLDCSKKAI 466
            | ...:.:.||            ..||    |: :|   .:||      |.|.|:
Zfish   284 DFLKSTTVFGL------------PTRS----HT-QC---SVTP------SPSAHS---------- 312

  Fly   467 APKETVIAQAQKPSSSPPAVVMANTTTNSMISHSSPTATPICETDKNEYRKFKVKMPLKYEFKNK 531
                       .|..||               .||||:..|
Zfish   313 -----------SPERSP---------------GSSPTSASI------------------------ 327

  Fly   532 TCVKQEPSLKEVDQEMSLPQEEEEDQVMHPEPDSICPSTTTHLGDEHMLMMERERERERERIQER 596
                 ||      :|..||               ..|:.... |..|.
Zfish   328 -----EP------REAFLP---------------FSPALYNR-GLNHY----------------- 348

  Fly   597 EPSNQQPASSTVIVLEHNSGGQARTIVPLSKPYYEPDPPGERYMRFGQPSSSILETILTSQHRLE 661
              ....||.                    |.|:| |:|...||:....|.||:
Zfish   349 --PGYSPAG--------------------SMPFY-PNPHYSRYLMHHYPVSSL------------ 378

  Fly   662 AAAAAANACRQANAATPPPTSPTEMAYSYKKSQRYGNAVSPDSSSNLGQNPEQLSSSAVVVGEQE 726
                           :.|.|......:.|   ..|.:.|.|    ::...|..|||        |
Zfish   379 ---------------SGPSTLGGIFPHMY---PFYSSLVPP----HVPFPPSMLSS--------E 413

  Fly   727 MTRATMIKGECSPPPPSHHHHNVIFSPSRHAAYLGAGEAGGHSPSPGYPGYPHYGAAATSTFHSP 791
            .:|..|:      ||.|....:::. |:..:|:                      :||||....|
Zfish   414 GSRQFML------PPDSPAPRDILL-PAATSAF----------------------SAATSLKDKP 449

  Fly   792 PHSSHSPFDRQSNASSGAGSATNLHLLQTSTQMLNHPLMQPLTPLQRLSPLRISPPSSLSPDGNS 856
            .|....|: ..:..|..||||.:...:.|                        .|.|::.    |
Zfish   450 LHGHGHPY-APAGGSPTAGSAASTGCIPT------------------------KPTSAIL----S 485

  Fly   857 CPRSGSP---LSPNSLASRGYRSLPYPLKKKDGKMHYECNVCCKTFGQLSNLKVHLRTHSGERPF 918
            ..||...   ||.....|.||:||.|||||::||:.||||||.||||||||||||||.|||||||
Zfish   486 TSRSEDEAINLSKMKRGSTGYKSLDYPLKKQNGKIKYECNVCTKTFGQLSNLKVHLRVHSGERPF 550

  Fly   919 KCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLRLHSGQKPYACDLCPQKF 983
            ||..|.|.||||||||||:|||||||||:|.:|.||||||||||||||||||:|||.|.:||.||
Zfish   551 KCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKICPAKF 615

  Fly   984 TQFVHLKLHKRLHTNDRPYVCQGCDKKYISASGLRTHWK--------TTSC---KPNNLEEE--- 1034
            ||||||||||||||.:||:.|..|...||..|.||.|.|        :.||   :.|.:.||
Zfish   616 TQFVHLKLHKRLHTRERPHQCPHCHHNYIHLSSLRFHLKGYCLAVSPSPSCSLDELNRVNEEIER 680

  Fly  1035 --LAMAAAATSECLDKDHPEPDSREAYEQLTQHM--HPAVHPGLRHLSSGGQSPPRLIPLGNHMA 1095
              ::..|....|....|......::.:..|.|.|  ..:.|.|    |:||...||...|..:..
Zfish   681 FDISDNADRLEEMEGFDVEGMVEKQIFGLLWQEMDFKASYHKG----STGGDLHPRAPALSAYHL 741

  Fly  1096 PQQQSHQQQQQQHQQQGV 1113
            .:..|.....:.|:...:
Zfish   742 NEHDSEASVIKVHRSSPI 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	53/129 (41%)
		C2H2 Zn finger	892..912	CDD:275368	18/19 (95%)
		zf-H2C2_2	904..929	CDD:290200	19/24 (79%)
		C2H2 Zn finger	920..940	CDD:275368	14/19 (74%)
		zf-H2C2_2	932..957	CDD:290200	19/24 (79%)
		C2H2 Zn finger	948..968	CDD:275368	16/19 (84%)
		zf-H2C2_2	960..985	CDD:290200	19/24 (79%)
		C2H2 Zn finger	976..996	CDD:275368	16/19 (84%)
		C2H2 Zn finger	1004..1023	CDD:275368	9/26 (35%)
prdm1a	NP_955809.2	SET	95..200	CDD:214614	52/118 (44%)
		Latrophilin	<236..344	CDD:280509	43/280 (15%)
		COG5048	<517..634	CDD:227381	95/116 (82%)
		zf-C2H2	522..544	CDD:278523	20/21 (95%)
		C2H2 Zn finger	524..544	CDD:275368	18/19 (95%)
		zf-H2C2_2	536..561	CDD:290200	19/24 (79%)
		C2H2 Zn finger	552..572	CDD:275368	14/19 (74%)
		zf-H2C2_2	564..589	CDD:290200	19/24 (79%)
		C2H2 Zn finger	580..600	CDD:275368	16/19 (84%)
		zf-H2C2_2	592..617	CDD:290200	19/24 (79%)
		C2H2 Zn finger	608..628	CDD:275368	16/19 (84%)
		zf-H2C2_2	620..>640	CDD:290200	13/19 (68%)
		C2H2 Zn finger	636..654	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580788
Domainoid	1	1.000	50	1.000	Domainoid score	I11740
eggNOG	1	0.900	-	-		E1_KOG2461
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1902
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233655at33208
OrthoFinder	1	1.000	-	-		FOG0006205
OrthoInspector	1	1.000	-	-		oto38720
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16515
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4128
SonicParanoid	1	1.000	-	-		X5144
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.980