DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp10 and alpi.1

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001014375.1	Gene:	alpi.1 / 541539	ZFINID:	ZDB-GENE-050327-78	Length:	532	Species:	Danio rerio

Alignment Length:	489	Identity:	207/489 - (42%)
Similarity:	280/489 - (57%)	Gaps:	33/489 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 ALDEELDTRFWHDKAQSILADKLAGHKKLNENRAKNVILFLGDGMSVHTIAATRAFMGDSNKQ-- 104
            |.:.|.|..:|:|:|:..|...|.  ..|..|||||:|||:||||.|.|::|.|...|....|
Zfish    30 AAEWEKDPAYWNDQARRTLQTALT--LPLRVNRAKNIILFVGDGMGVSTVSAARILRGQMEGQSG 92

  Fly   105 ----VFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQRGDCVTNSSSHV 165
                :..:.||||.|||||.|:::..|||:|||||..|||||..|:|::|:....:|.|...:.|
Zfish    93 EETILAMDTFPYLALSKTYCVDKQVADSASTATAYHCGVKANAKTVGLSAKAVAYECNTTFGNEV 157

  Fly   166 QSIGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIISSK----CSPDVNTDIARQ 226
            .|:...|:..||..|:|||.||.|||||..|||...|.|..|.::.|..    |.     |||.|
Zfish   158 FSVLHRAKAQGKSVGIVTTTRVQHASPAAAYAHSVSRKWYSDADVPSEARRQGCK-----DIATQ 217

  Fly   227 LVEWPVGQELRVIMGGGRSYFRDQS----QHDETGVSGLRTDGRDLISDWREIKKQQGAEGKYVW 287
            ||   ...::.||:||||.|...:.    ::..:...|.|.|.::||:.|...:|  |...:|||
Zfish   218 LV---TNTDIDVILGGGRMYMTPKGTPDPEYSSSSHKGDRKDKKNLINVWLNARK--GRNAQYVW 277

  Fly   288 SLKGLKETDISKTDYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIKMLSKNEEGYFLFV 352
            :.:.....|:..||.|:|||:...:.:...|.||.    :||:.||||.||::||||.:|:||||
Zfish   278 NKEQFNAVDVKTTDCLMGLFEPKDMRFEVFRNRTR----DPSIVDMTEKAIQILSKNPKGFFLFV 338

  Fly   353 ESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRRQNIL 417
            |.||||..||...|..||.:|..|..|::.|.::|.|.|||.|||:||||..:..|...|...|.
Zfish   339 EGGRIDHGHHDGVAKLALTETIMFDRAIQRASELTSESDTLTVVTADHSHVFTFGGKTPRGNPIF 403

  Fly   418 SLAPNLADDELPFTILSYANGPGFDDTYSTKDGRIDLSHADTTSAEFEFQATVPLSSETHGAEDV 482
            .|||..|:|:||:|.:.||||||:|....|   |.::|..|....|::.||.|||.|||||.|||
Zfish   404 GLAPKQAEDDLPYTSILYANGPGYDHVNGT---RGNVSVLDYYDEEYKQQAAVPLESETHGGEDV 465

  Fly   483 GVFASGPFEHLFTGNYEQSAIPAMMAYAANIGPF 516
            .::|.||..|||.|..||:.:...|||||.:.|:
Zfish   466 AIYAKGPMAHLFHGVKEQNYVAHAMAYAACLEPY 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	198/467 (42%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	193/449 (43%)
alpi.1	NP_001014375.1	PhoA	46..493	CDD:224699	197/465 (42%)
alpi.1	NP_001014375.1	Alk_phosphatase	61..496	CDD:278666	195/451 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593232
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2001
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm6481
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910