DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blanks and ILF3

DIOPT Version :9

Sequence 1:	NP_647966.1	Gene:	blanks / 38620	FlyBaseID:	FBgn0035608	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001381737.1	Gene:	ILF3 / 3609	HGNCID:	6038	Length:	898	Species:	Homo sapiens

Alignment Length:	290	Identity:	73/290 - (25%)
Similarity:	113/290 - (38%)	Gaps:	44/290 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PLADNLKKTAMGGENKSDEKGTVSSEPKALSDQITSSMRVTKNKIADDKSSDVITDDATNGRKK- 101
            ||...:.|..   :|::....||...|..     |.::...|..:.:|      .::.:..:||
Human   338 PLPSKMPKKP---KNENPVDYTVQIPPST-----TYAITPMKRPMEED------GEEKSPSKKKK 388

  Fly   102 --QKKNKKAKIRPLTMPVTSKDALMVLNELKGVTVDNMQIKR-DHEGKIMA-----RVVVNSKKY 158
              |||.:||:      |..:.:|||.||:||    ..:|.|. ...|.:.|     .|.|:...:
Human   389 KIQKKEEKAE------PPQAMNALMRLNQLK----PGLQYKLVSQTGPVHAPIFTMSVEVDGNSF 443

  Fly   159 EAEGSSVNSARNAACEKALQEILTTKMKAVLDGPGKSLESDEDDILEKMASYAIHKLGEEWKTDD 223
            ||.|.|..:|:.....|.||:     |.......|:.....||...|..|..|:.......:...
Human   444 EASGPSKKTAKLHVAVKVLQD-----MGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVS 503

  Fly   224 IDVATLYNDLKNKQTSVVEPKKP-LPETWKNMHPCMVLNYMRPQCTFIVSGGTGTNQNNTFSMSV 287
            ...|...:|...:.   |:.:.| |.:..||  |.|.||..|....:.:...||.:.:..|.|.|
Human   504 TPSAAFPSDATAEN---VKQQGPILTKHGKN--PVMELNEKRRGLKYELISETGGSHDKRFVMEV 563

  Fly   288 CVDNCEFNAEGPSKKAARYKLSALVCNKLF 317
            .||..:|...|.:||.|:...:.....|||
Human   564 EVDGQKFQGAGSNKKVAKAYAALAALEKLF 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	Identity
blanks	NP_647966.1	None
ILF3	NP_001381737.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..86
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..401	11/54 (20%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	371..389	4/23 (17%)
		Interaction with PRMT1. /evidence=ECO:0000269\|PubMed:10749851	613..898
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..664
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..898
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158155
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930