DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and Ir8a

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	763	Identity:	146/763 - (19%)
Similarity:	252/763 - (33%)	Gaps:	224/763 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 RQIAVVDLACGA-----------VSRRFLELASAKMLYSEKFHWLLIEDFAWHGRTQTAEGSGKR 206
            |.:.:.||.||:           |.|..:..|..    |..:...:.:|.     ..||..|...
  Fly   247 RSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQV----SPGYPLAIYQDC-----NATASSSEVS 302

  Fly   207 DDGEMEEEE--------------PPGQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAA 257
            |..|.::..              ||...||......:|.               ||.|..:| |.
  Fly   303 DPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPG---------------LTFAVNIS-AG 351

  Fly   258 HYTLFDVWNPGLNYGGHVNLTEIGSFTPTEGIQLHTWFRTTSTVRRRMDMQHARVRCMVVVTNKN 322
            :|:           ..|...|::.:::....::|..  .|.|..||...:..|.......:..:.
  Fly   352 YYS-----------SEHEAKTDLAAWSSVGEMRLLN--ETISPARRFFRIGTAESIPWSYLRREE 403

  Fly   323 MTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTF--VLSRTTSWGYVKN-GRFDGMIGAL 384
            .||.|:    ...|| :.....:..:.::.:....|:.|  |.......|.:.. |.:||::|.|
  Fly   404 GTGELI----RDRSG-LPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDL 463

  Fly   385 IRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFI-FRHP-RSTQKDRIVFLQPFTNDVWILIV 447
            :|.|||...|.:..:.||.:.||.....:......| .|.| |.|...:  |:.....:||:.||
  Fly   464 VRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFK--FMTVLRLEVWLSIV 526

  Fly   448 GCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVS 512
            ...|.|..::||:.    |..|                  |..:..::......|..|
  Fly   527 AALVGTAIMIWFMD----KYSP------------------YSSRNNRQAYPYACREFT------- 562

  Fly   513 KEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQ 577
                                                              ..||..|.:.....|
  Fly   563 --------------------------------------------------LRESFWFALTSFTPQ 577

  Fly   578 GLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKT-IKTLSDLVHSS------LK- 634
            |.|.:...:|||.:|....||...:...::|::...|.:|:.:| :::|..|...|      :|
  Fly   578 GGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKD 642

  Fly   635 -------VGM---EDILYN--RDYFLH-TKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPVS 686
                   |.|   ||.||.  ::..|: :||.....::                 |.|:
  Fly   643 SDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIW-----------------DYPI------ 684

  Fly   687 TDPAKSYRDI---VHSHETGAHAKDNAASNWLDPETGLLRHLGFAF-HVDVAAAYKIIAETFSEQ 747
               .:.|..|   ::|.:..|.||:..|:  :|..    .:..:|| |......|:|...
  Fly   685 ---KEQYGHILLAINSSQPVADAKEGFAN--VDAH----ENADYAFIHDSAEIKYEITRN----- 735

  Fly   748 DICDLTEV-SMFPPQKTVSIMQKNSPMRKVISYGLRRVTETGIL-TYHFNVWH-SRKPPCVKKIE 809
              |:|||| .:|..|.....:|:.|.:...:||.:..:.:.... ......|: |..|.|  .:.
  Fly   736 --CNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNC--PLS 796

  Fly   810 TSDLHVDMDTVSSALLILLFSYAITLMILGTEIL-YSKWHNRIQLKWV 856
            .....:.::::....:..||...:.:|.||.|:| |.|..|.:::..|
  Fly   797 EDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALEITQV 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	32/118 (27%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	59/292 (20%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	100/527 (19%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	74/417 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910