DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prpk and tp53rk

DIOPT Version :9

Sequence 1:	NP_647948.1	Gene:	Prpk / 38600	FlyBaseID:	FBgn0035590	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_001018386.2	Gene:	tp53rk / 553571	ZFINID:	ZDB-GENE-050522-123	Length:	231	Species:	Danio rerio

Alignment Length:	224	Identity:	98/224 - (43%)
Similarity:	145/224 - (64%)	Gaps:	14/224 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EILKQGAEGRLYLGDFKGEACLIKERFVKKYRHPELNTQITRQRMKAEAKASGRCLAAGILAPKI 68
            :::|||||.|:|...|.|.:.:|||||.|.|||||::.::||:|...|.::..||..|||.||.:
Zfish    19 QMIKQGAEARVYRSTFLGRSVIIKERFPKLYRHPEVDEKLTRRRTTQEVRSILRCRRAGISAPVV 83

  Fly    69 LHSDLNTHKLYMEYFDAAKTAKQFIQETVSTQTEDEAKKCLLEFCTRIGEIIGKMHSNHIIHGDL 133
            ...|..||.::::  |...:..  :::.:.:|.:.     |.....||||::.:||...:|||||
Zfish    84 YFVDYATHCIFLQ--DVVNSVS--VRDHIRSQPDG-----LQTLAERIGEVLAQMHDEDVIHGDL 139

  Fly   134 TTSNILINPKGG---DYDVILIDFGLSHYNQATEDKGVDLYVLERALLSTHSEQPYIFEHVLAAY 195
            ||||:|:. .||   |::::|||||||:.:...|||||||||||:|.||||.:...:||.:|.:|
Zfish   140 TTSNMLLT-SGGQQQDFNLVLIDFGLSYISALPEDKGVDLYVLEKAFLSTHPKTEALFERLLKSY 203

  Fly   196 RTACGKDEQAVLTKFEEVRARGRKRTMIG 224
            .:| .|...||:.|.:|||.|||||:|:|
Zfish   204 SSA-SKKSTAVIKKLDEVRLRGRKRSMVG 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prpk	NP_647948.1	PKc_like	3..224	CDD:304357	97/222 (44%)
tp53rk	NP_001018386.2	Bud32	21..231	CDD:226168	97/220 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585294
Domainoid	1	1.000	106	1.000	Domainoid score	I6544
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6042
Inparanoid	1	1.050	181	1.000	Inparanoid score	I3982
OMA	1	1.010	-	-		QHG62179
OrthoDB	1	1.010	-	-		D1425238at2759
OrthoFinder	1	1.000	-	-		FOG0003198
OrthoInspector	1	1.000	-	-		oto41041
orthoMCL	1	0.900	-	-		OOG6_101388
Panther	1	1.100	-	-	LDO	PTHR12209
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R156
SonicParanoid	1	1.000	-	-		X2602
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940