DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gen and RAD27

DIOPT Version :9

Sequence 1:	NP_647943.2	Gene:	Gen / 38594	FlyBaseID:	FBgn0263831	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_012809.1	Gene:	RAD27 / 853747	SGDID:	S000001596	Length:	382	Species:	Saccharomyces cerevisiae

Alignment Length:	522	Identity:	110/522 - (21%)
Similarity:	183/522 - (35%)	Gaps:	173/522 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVKELWGVLTPH----CERKPINELRGKKVAIDLAGWVCESLNVVDYFVHPRH----------- 50
            ||:|.|..:::.|    ..:..|....|:|||||      .|:::..:.:..|.
Yeast     1 MGIKGLNAIISEHVPSAIRKSDIKSFFGRKVAID------ASMSLYQFLIAVRQQDGGQLTNEAG 59

  Fly    51 ----HLKNLFFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSK 111
                ||..:|:||..:|...:.|.:|.:|..|.|||..:.||:..:....| |.:...|:.:..|
Yeast    60 ETTSHLMGMFYRTLRMIDNGIKPCYVFDGKPPDLKSHELTKRSSRRVETEK-KLAEATTELEKMK 123

  Fly   112 GDKGRSRFNHVLK----QCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGA 172
            .::   |...|.|    :.:.||..|||..:..|.||||.||.|.|.|.|....|:|.|...|..
Yeast   124 QER---RLVKVSKEHNEEAQKLLGLMGIPYIIAPTEAEAQCAELAKKGKVYAAASEDMDTLCYRT 185

  Fly   173 VRVYRNFSVSTQGAQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGV 237
            ..:.|:.:.|     .|....:...|...:...:|...::.:.:.::.||||| :.|.|:|....
Yeast   186 PFLLRHLTFS-----EAKKEPIHEIDTELVLRGLDLTIEQFVDLCIMLGCDYC-ESIRGVGPVTA 244

  Fly   238 LKLFNKYKETEILDRMRSWRGETDKYNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKGC 302
            |||...:                                   |.|.|.....:||.|
Yeast   245 LKLIKTH-----------------------------------GSIEKIVEFIESGES-------- 266

  Fly   303 DESLWKEQRLSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTIP--NLNLNWRQPNLVKFIKQI 365
            :.:.||                 :..|:|.::....|| :|:.|.  .:||.|..|...:.|
Yeast   267 NNTKWK-----------------IPEDWPYKQARMLFL-DPEVIDGNEINLKWSPPKEKELI--- 310

  Fly   366 GHLLQWPEIYCFQKFFPILTRWQVQQSKQEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGL 430
                   |..|..|.|.                       ::|...|:..|:      .|:..|:
Yeast   311 -------EYLCDDKKFS-----------------------EERVKSGISRLK------KGLKSGI 339

  Fly   431 IPDKQIAEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEK--PAKKTTRKKKTASEEE 493
                          :|..:.::.:.|                |:||:  .|.|..::.|..::.:
Yeast   340 --------------QGRLDGFFQVVP----------------KTKEQLAAAAKRAQENKKLNKNK 374

  Fly   494 NK 495
            ||
Yeast   375 NK 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	95/408 (23%)
Gen	NP_647943.2	H3TH_GEN1	210..342	CDD:188625	23/131 (18%)
RAD27	NP_012809.1	PTZ00217	1..364	CDD:240317	107/508 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810