DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gen and zgc:110269

DIOPT Version :9

Sequence 1:	NP_647943.2	Gene:	Gen / 38594	FlyBaseID:	FBgn0263831	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001017611.2	Gene:	zgc:110269 / 550274	ZFINID:	ZDB-GENE-050417-81	Length:	350	Species:	Danio rerio

Alignment Length:	350	Identity:	98/350 - (28%)
Similarity:	152/350 - (43%)	Gaps:	72/350 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVKELWGVL---TPHCER-KPINELRGKKVAIDLAGWVCESLNVVDYF--VHPRH----HLKNL 55
            ||:.:|..::   .|...| |.|.:..||.:|:|.:       .||:.|  ..|.|    .|..|
Zfish     1 MGITKLAHLIHFDAPASMRSKEIGDYSGKIIALDTS-------IVVNQFRSALPGHLKLSPLAGL 58

  Fly    56 FFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQ-PSKGDKGRSRF 119
            |:||...:...:.|||||:|..|..|..|:.||.:          |...:.|| |:.|    |.|
Zfish    59 FYRTLAFLEHDIKPVFVLDGKPPHQKRAVLEKRAQ----------STGWSSSQSPNTG----SAF 109

  Fly   120 NHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSVSTQ 184
            |   ::|..||..||:.|::.||||||.||.|.|.|.|:.|.|:|.|..|:|...:.|..:
Zfish   110 N---QECLRLLHLMGVPCIKAPGEAEALCAHLAKIGTVNAVASEDMDTLAFGGTVLLRQLN---- 167

  Fly   185 GAQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKYKETE- 248
               |.....:..|.:.::...:....::.:.:.:|.||||| |.|||:|....|||..::...|
Zfish   168 ---AKRDSEITEYSLPKLLEALQLKYEEFVDLCILLGCDYC-DKIGGLGPSRALKLIKEHHTIEG 228

  Fly   249 ILDRMR--------SWRGETDKYNALEI-RVDDKSIC-SNCGHIGKTQSHTKSGCSVCRTHKGCD 303
            :::.:.        :|:.:..:....|. ::||..:. |.....|..|..             |.
Zfish   229 VMEHVNRKTHPIPLNWQYKDARKLFFETPKIDDPVLAWSEPDEEGLVQFL-------------CK 280

  Fly   304 ESLWKEQRL-----SIKSELTLRRK 323
            |...||:|:     ..:..|..|||
Zfish   281 EKPLKEERVRGRMKKFREMLLKRRK 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	97/349 (28%)
Gen	NP_647943.2	H3TH_GEN1	210..342	CDD:188625	30/129 (23%)
zgc:110269	NP_001017611.2	PTZ00217	1..346	CDD:240317	97/349 (28%)
		N-domain	1..95		32/110 (29%)
		PIN_SF	2..325	CDD:301351	96/348 (28%)
		I-domain	110..223		42/123 (34%)
		H3TH_FEN1-Euk	191..255	CDD:188627	16/64 (25%)
		Interaction with PCNA. /evidence=ECO:0000250	317..325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1094524at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820