Protein Alignment Gen and exo1

DIOPT Version :10

• Sequence 1: NP_647943.2
• Gene: Gen / 38594
• FlyBaseID: FBgn0263831
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: XP_073783256.1
• Gene: exo1 / 406778
• ZFINID: ZDB-GENE-040426-2828
• Length: 845
• Species: Danio rerio
• Alignment Length: 827
• Identity: 181/827 - (21%)
• Similarity: 288/827 - (34%)
• Gaps: 249/827 - (30%)

  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWV-------CESL-------NVVDY---FVHP 48
            ||::.|...:....|...:.:.||:.||:|...|:       .|.|       ..|.|   ||.
Zfish    40 MGIQGLLQFIKDASEPMHVKKYRGQTVAVDTYCWLHKGAFSCAEKLAKGEPTDQYVSYCMKFVD- 103

  Fly    49 RHHLKNLFFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNE-----LQ-----FRGVKPKNSPE 103
                        .|:...|.|:.|.:|.....|.:|...|.|     ||     .|..|...:.|
Zfish   104 ------------MLLSFGVKPILVFDGRNLPSKQEVEKSRRERRQANLQKGKQLLREGKITEARE 156

  Fly   104 C-TQS---QPSKGDKGRSRFNHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQD 164
            | |:|   .||..       :.|::...|    .|:.||..|.||:|..|||||..:...||::|
Zfish   157 CFTRSVNITPSMA-------HDVIRAART----RGVDCVVAPYEADAQLAFLNKSDIAQAVITED 210

  Fly   165 SDCFAYGAVRVYRNFSVSTQG---AQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCP 226
            ||..|:|..:|.........|   .|...|....:.::        |.::|...|.:|.||||.
Zfish   211 SDLLAFGCKKVILKMDKQGNGLEIEQCHLGRCKSLGNI--------FTEEKFRYMCILSGCDYL- 266

  Fly   227 DGIGGIGKDGVLKLFNKYKETEILDRMRSWRGETDKYNALEIRVDDKSICSNCGHIGKTQSH--- 288
            ..:.|||.....||.......:||..::    :..:|..::|.|.::.|      .|.|:::
Zfish   267 QSLYGIGLGKACKLLRMANNPDILKVIK----KMGQYLKMDISVPEEYI------EGFTKANNTF 321

  Fly   289 -----------------------TKSGCSVCRTHKGCDESLWKEQRLSIKSELTLRRKALLSPDF 330
                                   ..:..|...|:.|.::.|  :..|......|::|....:||.
Zfish   322 LYQLVFDPLRRKVVPLNPYPDHINPAALSYAGTNVGDEKGL--QMALGNLDINTMQRIDDFNPDA 384

  Fly   331 PNEEIIAEFLSEPDTIPNLNLNWR---------QPNLVKFIKQIGHLLQWPEIYCFQKFFPILTR 386
            |.        ::|...|. :.:|.         |.::            |.     |.:.|..|:
Zfish   385 PQ--------TQPPKAPR-SSSWNDRCDKTATTQASI------------WS-----QNYEPGCTK 423

  Fly   387 WQVQQSKQEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQIAEYEAEHPKGIEELY 451
            .|...|.:     :|.....|..:..|.||:|             |.:   |.:.:.|:  |:..
Zfish   424 PQSPTSPK-----RPPPTRGKERIVSVQSLKL-------------PQR---ESQVKRPR--EDTS 465

  Fly   452 YTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKENE--PNSKPKRVVRKIKAQP 514
            .:::  |:||.     ..|.:| :..|..:.|.|..|.....:|||.  ..|.|.|        |
Zfish   466 LSVD--DLLEQ-----YTAGVK-RHCPETQPTTKPLTNDNMVSKENHCGSTSGPSR--------P 514

  Fly   515 EENQPLLHQFLGRKKEGTPVKAPAPQRQQCSTPITKFLPSDLESDCDAEEFDMSDIVKGIISNPN 579
            ......|.|:..|.:|||      .::..||    :|...|..:..:.:|....|..:.:.|. .
Zfish   515 RNRFATLLQWRNRSEEGT------EEQGTCS----RFFCHDESNIAETQEDSKQDSSQSVESQ-E 568

  Fly   580 AKPALTNHDGHQLHYEPMAE-------------DLSLRLAQMSLG-------------NVNESPK 618
            ...:.:..|...|..||..|             ..|.|.|.:.||             :|:...:
Zfish   569 KHVSQSGGDTSSLCEEPEREQDKDEPSSPPASPSCSSRPASVGLGVFSWSGTTKELNKSVSHPAR 633

  Fly   619 VETKRD--------LSQVDQLPQSK-RFSLEDSFDLLVKGDLQKLARTPVERFKMQHRISEKI-P 673
            ..|:|.        ||.:.|..::| |.|.        .|....|:.:|||.       ||.. .
Zfish   634 DSTERQRSSSTPSGLSTLQQFHRNKARISW--------AGPGLSLSSSPVEG-------SEDAGN 683

  Fly   674 TPVKPLDNISYFFNQSSD-NADVFEELMNSSLVPQDQEDNAEDEEED 719
            :|..|....|.:|:|||. :|.|     .:|||.:|..|..::.:.|
Zfish   684 SPGSPPSQDSAYFSQSSSISASV-----ENSLVTEDNSDKEKERDSD 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	2..207	CDD:350217	59/238 (25%)
		H3TH_GEN1	210..342	CDD:188625	30/157 (19%)
		Chromo_2	400..473	CDD:465841	14/72 (19%)
exo1	XP_073783256.1	None