DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gen and tos

DIOPT Version :9

Sequence 1:	NP_647943.2	Gene:	Gen / 38594	FlyBaseID:	FBgn0263831	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	145/745 - (19%)
Similarity:	265/745 - (35%)	Gaps:	205/745 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWV-------CESL-NVVDYFVHPRHHLKNLFF 57
            ||:..|...:.....:..:.::||..||:|...|:       .|.| ...|..|:.::.||.:..
  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLARGEDTDVYIQYCLKYVNM 65

  Fly    58 RTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFN-- 120
            ...|    .:.|:.|.:|  ..|.::.:.::.....|....:.:.|..:.  .:.::.||...
  Fly    66 LLSY----DIKPILVFDG--QHLPAKALTEKRRRDSRKQSKERAAELLRL--GRIEEARSHMRRC 122

  Fly   121 ---------HVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVY 176
                     .::::|.    |..:.|:..|.||:|..|:||:..:...:|::|||...:||..:.
  Fly   123 VDVTHDMALRLIRECR----SRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNII 183

  Fly   177 RNFSVSTQG-------AQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGK 234
            ....::..|       ...|.|...:.|..           .|...|.:|.||||. |.:.|||.
  Fly   184 FKLDLNGSGLLVEAEKLHLAMGCTEEKYHF-----------DKFRRMCILSGCDYL-DSLPGIGL 236

  Fly   235 DGVLKLFNKYKETEI---LDRMRSWRG----ETDK------------------YNALEIRVD--- 271
            ....|...|.::.::   |.::.|:..    |.|.                  ||.||.|:.
  Fly   237 AKACKFILKTEQEDMRIALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLERRMQRLC 301

  Fly   272 -------DKSICSNCGHI---GKTQSHTKSG----CSVCRTHKGCDESLWKEQRLSIKSELTLRR 322
                   |:..|||.|.:   .:...|...|    .|:.|......|..|...: ::|..   :.
  Fly   302 ALEDYETDERYCSNAGTLLEDSEQALHLALGNLNPFSMKRLDSWTPEKAWPTPK-NVKRS---KH 362

  Fly   323 KALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQ---IGHLLQWPEIYCFQKFFPIL 384
            |::...:|.:|              |.:...::.....|.|:   :|..|. .||...|:
  Fly   363 KSIWQTNFQSE--------------NTHTPKKENPCALFFKKVDFVGKTLN-EEIEANQR----- 407

  Fly   385 TRWQVQQSKQ-EKILIQPHEIIKKRTVKGVPSLE-----LRWHDPSGIFKG-------------- 429
                ::|:|| |..|...:....||  :..||.|     .|...||.:.|.
  Fly   408 ----LEQAKQTEAELFNMYSFKAKR--RRSPSREDSVDQERTPPPSPVHKSRHNPFAKERTGEEA 466

  Fly   430 ---------------LIPDKQIAEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPA 479
                           |:..|:.:..:.|  .|:::       :|.|:.      :.|.|.:.:..
  Fly   467 NQRSPVVCENASLLRLLSPKKASPLDGE--AGVKK-------VDSLKR------SIFAKEQVQIR 516

  Fly   480 KK--TTRKKKTASEEENKENEPNSKPKRVVRKIKAQPEENQPLLHQFLGRKK-----EGTPVKAP 537
            .:  .|:.::|..:.|:..:..|.             :.::..|....|.||     :..|.|.|
  Fly   517 SRFFATQDEQTRLQREHLRDTEND-------------DMDEQKLSSHSGHKKLRLVCKDIPGKNP 568

  Fly   538 APQRQQCSTPITKFLPSDLESDCDAEEFDMSDIV-KGIISNPNAKPALTNHDGHQLHYEPMAEDL 601
            .  ||:||:.|     ||.|:|.|.....:.:.. ||:.|...::..| |:...|:..|......
  Fly   569 I--RQRCSSQI-----SDGETDTDTTASSLLESQDKGVPSPLESQEDL-NNSQPQIPTEGNTNST 625

  Fly   602 SLRLAQMSLGNVNESPKVETKRDLSQVDQL 631
            ::|:..:.| .:..||:...:.|.:..|.:
  Fly   626 TIRIKSLDL-LLENSPEPTQESDRNNNDAI 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	89/454 (20%)
Gen	NP_647943.2	H3TH_GEN1	210..342	CDD:188625	37/173 (21%)
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	41/214 (19%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	17/77 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0258
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11081
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840