Protein Alignment Gen and tos

DIOPT Version :10

• Sequence 1: NP_647943.2
• Gene: Gen / 38594
• FlyBaseID: FBgn0263831
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_477145.1
• Gene: tos / 35119
• FlyBaseID: FBgn0015553
• Length: 732
• Species: Drosophila melanogaster
• Alignment Length: 745
• Identity: 145/745 - (19%)
• Similarity: 265/745 - (35%)
• Gaps: 205/745 - (27%)

  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWV-------CESL-NVVDYFVHPRHHLKNLFF 57
            ||:..|...:.....:..:.::||..||:|...|:       .|.| ...|..|:.::.||.:..
  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLARGEDTDVYIQYCLKYVNM 65

  Fly    58 RTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFN-- 120
            ...|    .:.|:.|.:|  ..|.::.:.::.....|....:.:.|..:.  .:.::.||...
  Fly    66 LLSY----DIKPILVFDG--QHLPAKALTEKRRRDSRKQSKERAAELLRL--GRIEEARSHMRRC 122

  Fly   121 ---------HVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVY 176
                     .::::|.    |..:.|:..|.||:|..|:||:..:...:|::|||...:||..:.
  Fly   123 VDVTHDMALRLIRECR----SRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNII 183

  Fly   177 RNFSVSTQG-------AQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGK 234
            ....::..|       ...|.|...:.|..           .|...|.:|.||||. |.:.|||.
  Fly   184 FKLDLNGSGLLVEAEKLHLAMGCTEEKYHF-----------DKFRRMCILSGCDYL-DSLPGIGL 236

  Fly   235 DGVLKLFNKYKETEI---LDRMRSWRG----ETDK------------------YNALEIRVD--- 271
            ....|...|.::.::   |.::.|:..    |.|.                  ||.||.|:.
  Fly   237 AKACKFILKTEQEDMRIALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLERRMQRLC 301

  Fly   272 -------DKSICSNCGHI---GKTQSHTKSG----CSVCRTHKGCDESLWKEQRLSIKSELTLRR 322
                   |:..|||.|.:   .:...|...|    .|:.|......|..|...: ::|..   :.
  Fly   302 ALEDYETDERYCSNAGTLLEDSEQALHLALGNLNPFSMKRLDSWTPEKAWPTPK-NVKRS---KH 362

  Fly   323 KALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQ---IGHLLQWPEIYCFQKFFPIL 384
            |::...:|.:|              |.:...::.....|.|:   :|..|. .||...|:
  Fly   363 KSIWQTNFQSE--------------NTHTPKKENPCALFFKKVDFVGKTLN-EEIEANQR----- 407

  Fly   385 TRWQVQQSKQ-EKILIQPHEIIKKRTVKGVPSLE-----LRWHDPSGIFKG-------------- 429
                ::|:|| |..|...:....||  :..||.|     .|...||.:.|.
  Fly   408 ----LEQAKQTEAELFNMYSFKAKR--RRSPSREDSVDQERTPPPSPVHKSRHNPFAKERTGEEA 466

  Fly   430 ---------------LIPDKQIAEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPA 479
                           |:..|:.:..:.|  .|:::       :|.|:.      :.|.|.:.:..
  Fly   467 NQRSPVVCENASLLRLLSPKKASPLDGE--AGVKK-------VDSLKR------SIFAKEQVQIR 516

  Fly   480 KK--TTRKKKTASEEENKENEPNSKPKRVVRKIKAQPEENQPLLHQFLGRKK-----EGTPVKAP 537
            .:  .|:.::|..:.|:..:..|.             :.::..|....|.||     :..|.|.|
  Fly   517 SRFFATQDEQTRLQREHLRDTEND-------------DMDEQKLSSHSGHKKLRLVCKDIPGKNP 568

  Fly   538 APQRQQCSTPITKFLPSDLESDCDAEEFDMSDIV-KGIISNPNAKPALTNHDGHQLHYEPMAEDL 601
            .  ||:||:.|     ||.|:|.|.....:.:.. ||:.|...::..| |:...|:..|......
  Fly   569 I--RQRCSSQI-----SDGETDTDTTASSLLESQDKGVPSPLESQEDL-NNSQPQIPTEGNTNST 625

  Fly   602 SLRLAQMSLGNVNESPKVETKRDLSQVDQL 631
            ::|:..:.| .:..||:...:.|.:..|.:
  Fly   626 TIRIKSLDL-LLENSPEPTQESDRNNNDAI 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	2..207	CDD:350217	43/230 (19%)
		H3TH_GEN1	210..342	CDD:188625	37/173 (21%)
		Chromo_2	400..473	CDD:465841	16/106 (15%)
tos	NP_477145.1	PIN_EXO1	1..202	CDD:350207	41/212 (19%)
		H3TH_EXO1	214..291	CDD:188628	17/77 (22%)