Protein Alignment: Gen and GEN1

• Sequence 1: NP_647943.2
• Gene: Gen
• FlyBaseID: FBgn0263831
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_001123481.3
• Gene: GEN1
• HGNCID: 26881
• Length: 908
• Species: Homo sapiens
• Alignment Length: 740
• Identity: 213/741 (29%)
• Similarity: 346/741 (47%)
• Gaps: 101/741 (14%)

  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWVCESLNV---VDYFVHPRHHLKNLFFRTCYL 62
            |||.:||.:|.|..:..|:..|.||.:|:||:.||||:..|   :...:.|  ||:|||||..||
Human     1 MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMKP--HLRNLFFRISYL 63

  Fly    63 IWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFNHVLKQCE 127
            ....|..|||:||..||||:.||:|||:.:: |...|:..:.|         |||.|..||::|.
Human    64 TQMDVKLVFVMEGEPPKLKADVISKRNQSRY-GSSGKSWSQKT---------GRSHFKSVLRECL 118

  Fly   128 TLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSVSTQGAQAAAGG 192
            .:|..:||..||..|||||.||:||..|.|||.::.|.|.|.|||..|||||:::|:...
Human   119 HMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFTMNTKDPH----- 178

  Fly   193 AVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKYKETEILDRMRSWR 257
             ||.|.|..|.|::...:..::.:|:|.||||.|.|:.|:||:..|||....|...:|.|...|
Human   179 -VDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNRW- 241

  Fly   258 GETDKYNALEIRVDDK-SICSNCGHIGKTQSHTKSGCSVCRTHKGCDESLWK------------E 309
            .||...::.::.|..| :.||.|.|.|..:.|.::||.:|::.|.|:...::            :
Human   242 NETSCNSSPQLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEWHRTEHD 306

  Fly   310 QRLSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQIGHLLQWPEI 374
            ::|| :.|..:::||.....||..|:|.|||...|.:..: :.:::|:|:.|.:.....::||..
Human   307 RQLS-EVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKV-IRYQRPDLLLFQRFTLEKMEWPNH 369

  Fly   375 YCFQKFFPILTRWQVQQSK---QEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQI 436
            |..:|...:||.:.:.:.|   :....:||..|:|.|...||...|:.|..|...   .:.|||.
Human   370 YACEKLLVLLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHY---AMEDKQH 431

  Fly   437 AEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKENEPN- 500
            .|:          ...|||...:.|.|||::||.:.|.|.:...|   |:|....:||...||:
Human   432 GEF----------ALLTIEEESLFEAAYPEIVAVYQKQKLEIKGK---KQKRIKPKENNLPEPDE 483

  Fly   501 --SKPKRVVRKIKAQPEENQPLLHQFLGRKKEGTPVKAPAPQRQQCSTPITKFLPSDLESDC-DA 562
              |....:..|...:      :.|:...:...|.......||....::..:..||.:  :.| :|
Human   484 VMSFQSHMTLKPTCE------IFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKN--TPCLNA 540

  Fly   563 EEFDMSDI-------VKGIISNPNAKPALTNHDGHQLHYEPMAEDLSLRLAQMSLGNVNESPKVE 620
            :|..||.:       :|.:..:..::.:..|...|.:   .:..||.|........:.:.||.::
Human   541 QEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNI---SVIADLHLSTIDWEGTSFSNSPAIQ 602

  Fly   621 TKRDLSQVDQLPQSKRFSLEDSFDLLVKGDLQKLARTPVERFKMQHRISEKIPTPVKPLDNISYF 685
            .......:....:|:..::.|.|:     ::.:......||:..                ||...
Human   603 RNTFSHDLKSEVESELSAIPDGFE-----NIPEQLSCESERYTA----------------NIKKV 646

  Fly   686 FNQSSDNADVFEELMN--SSLVPQD 708
            .::.||.....|.|::  :.|..||
Human   647 LDEDSDGISPEEHLLSGITDLCLQD 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	144/400 (36%)
		H3TH_GEN1	210..342	CDD:188625	45/145 (31%)
GEN1	NP_001123481.3	PIN_GEN1	1..193	CDD:189039	90/210 (43%)
		XPG-N domain. {ECO:0000269|PubMed:26682650}	2..96		44/97 (45%)
		XPG-I domain. {ECO:0000269|PubMed:26682650}	122..208		39/92 (42%)
		H3TH_GEN1	195..338	CDD:188625	45/145 (31%)
		5'-3' exonuclease domain. {ECO:0000269|PubMed:26682650}	208..384		51/179 (28%)
		Chromodomain. {ECO:0000269|PubMed:26682650}	390..464		25/87 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C325369533
eggNOG	1	0.900				E1_COG0258
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2934
Isobase	1	0.950		0	Normalized mean entropy	S5877
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D1094524at2759
OrthoFinder	1	1.000				FOG0009091
OrthoInspector	1	1.000				T1074721
orthoMCL	1	0.900				OOG5_134343
Panther	1	1.100			LDO	PTHR11081
Phylome	1	0.910		0.667	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	12	11.710