DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gen and GEN1

DIOPT Version :10

Sequence 1:NP_647943.2 Gene:Gen / 38594 FlyBaseID:FBgn0263831 Length:726 Species:Drosophila melanogaster
Sequence 2:NP_872431.5 Gene:GEN1 / 348654 HGNCID:26881 Length:908 Species:Homo sapiens


Alignment Length:740 Identity:213/740 - (28%)
Similarity:346/740 - (46%) Gaps:101/740 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWVCESLNV---VDYFVHPRHHLKNLFFRTCYL 62
            |||.:||.:|.|..:..|:..|.||.:|:||:.||||:..|   :...:.|  ||:|||||..||
Human     1 MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMKP--HLRNLFFRISYL 63

  Fly    63 IWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFNHVLKQCE 127
            ....|..|||:||..||||:.||:|||:.:: |...|:..:.|         |||.|..||::|.
Human    64 TQMDVKLVFVMEGEPPKLKADVISKRNQSRY-GSSGKSWSQKT---------GRSHFKSVLRECL 118

  Fly   128 TLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSVSTQGAQAAAGG 192
            .:|..:||..||..|||||.||:||..|.|||.::.|.|.|.|||..|||||:::|:...     
Human   119 HMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFTMNTKDPH----- 178

  Fly   193 AVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKYKETEILDRMRSWR 257
             ||.|.|..|.|::...:..::.:|:|.||||.|.|:.|:||:..|||....|...:|.|...| 
Human   179 -VDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNRW- 241

  Fly   258 GETDKYNALEIRVDDK-SICSNCGHIGKTQSHTKSGCSVCRTHKGCDESLWK------------E 309
            .||...::.::.|..| :.||.|.|.|..:.|.::||.:|::.|.|:...::            :
Human   242 NETSCNSSPQLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEWHRTEHD 306

  Fly   310 QRLSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQIGHLLQWPEI 374
            ::|| :.|..:::||.....||..|:|.|||...|.:..: :.:::|:|:.|.:.....::||..
Human   307 RQLS-EVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKV-IRYQRPDLLLFQRFTLEKMEWPNH 369

  Fly   375 YCFQKFFPILTRWQVQQSK---QEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQI 436
            |..:|...:||.:.:.:.|   :....:||..|:|.|...||...|:.|..|...   .:.|||.
Human   370 YACEKLLVLLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHY---AMEDKQH 431

  Fly   437 AEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKENEPN- 500
            .|:          ...|||...:.|.|||::||.:.|.|.:...|   |:|....:||...||: 
Human   432 GEF----------ALLTIEEESLFEAAYPEIVAVYQKQKLEIKGK---KQKRIKPKENNLPEPDE 483

  Fly   501 --SKPKRVVRKIKAQPEENQPLLHQFLGRKKEGTPVKAPAPQRQQCSTPITKFLPSDLESDC-DA 562
              |....:..|...:      :.|:...:...|.......||....::..:..||.:  :.| :|
Human   484 VMSFQSHMTLKPTCE------IFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKN--TPCLNA 540

  Fly   563 EEFDMSDI-------VKGIISNPNAKPALTNHDGHQLHYEPMAEDLSLRLAQMSLGNVNESPKVE 620
            :|..||.:       :|.:..:..::.:..|...|.:   .:..||.|........:.:.||.::
Human   541 QEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNI---SVIADLHLSTIDWEGTSFSNSPAIQ 602

  Fly   621 TKRDLSQVDQLPQSKRFSLEDSFDLLVKGDLQKLARTPVERFKMQHRISEKIPTPVKPLDNISYF 685
            .......:....:|:..::.|.|:     ::.:......||:..                ||...
Human   603 RNTFSHDLKSEVESELSAIPDGFE-----NIPEQLSCESERYTA----------------NIKKV 646

  Fly   686 FNQSSDNADVFEELMN--SSLVPQD 708
            .::.||.....|.|::  :.|..||
Human   647 LDEDSDGISPEEHLLSGITDLCLQD 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GenNP_647943.2 PIN_GEN1 2..207 CDD:350217 89/207 (43%)
H3TH_GEN1 210..342 CDD:188625 45/144 (31%)
Chromo_2 400..473 CDD:465841 23/72 (32%)
GEN1NP_872431.5 PIN_GEN1 2..206 CDD:350217 91/221 (41%)
XPG-N domain. /evidence=ECO:0000269|PubMed:26682650 2..96 43/96 (45%)
XPG-I domain. /evidence=ECO:0000269|PubMed:26682650 122..208 38/91 (42%)
H3TH_GEN1 195..338 CDD:188625 45/144 (31%)
5'-3' exonuclease domain. /evidence=ECO:0000269|PubMed:26682650 208..384 51/178 (29%)
Chromodomain. /evidence=ECO:0000269|PubMed:26682650 390..464 25/86 (29%)
Chromo_2 398..458 CDD:465841 23/72 (32%)

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