DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gen and GEN1

DIOPT Version :9

Sequence 1:	NP_647943.2	Gene:	Gen / 38594	FlyBaseID:	FBgn0263831	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001123481.3	Gene:	GEN1 / 348654	HGNCID:	26881	Length:	908	Species:	Homo sapiens

Alignment Length:	740	Identity:	213/740 - (28%)
Similarity:	346/740 - (46%)	Gaps:	101/740 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWVCESLNV---VDYFVHPRHHLKNLFFRTCYL 62
            |||.:||.:|.|..:..|:..|.||.:|:||:.||||:..|   :...:.|  ||:|||||..||
Human     1 MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMKP--HLRNLFFRISYL 63

  Fly    63 IWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFNHVLKQCE 127
            ....|..|||:||..||||:.||:|||:.:: |...|:..:.|         |||.|..||::|.
Human    64 TQMDVKLVFVMEGEPPKLKADVISKRNQSRY-GSSGKSWSQKT---------GRSHFKSVLRECL 118

  Fly   128 TLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSVSTQGAQAAAGG 192
            .:|..:||..||..|||||.||:||..|.|||.::.|.|.|.|||..|||||:::|:...
Human   119 HMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFTMNTKDPH----- 178

  Fly   193 AVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKYKETEILDRMRSWR 257
             ||.|.|..|.|::...:..::.:|:|.||||.|.|:.|:||:..|||....|...:|.|...|
Human   179 -VDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNRW- 241

  Fly   258 GETDKYNALEIRVDDK-SICSNCGHIGKTQSHTKSGCSVCRTHKGCDESLWK------------E 309
            .||...::.::.|..| :.||.|.|.|..:.|.::||.:|::.|.|:...::            :
Human   242 NETSCNSSPQLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEWHRTEHD 306

  Fly   310 QRLSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQIGHLLQWPEI 374
            ::|| :.|..:::||.....||..|:|.|||...|.:..: :.:::|:|:.|.:.....::||..
Human   307 RQLS-EVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKV-IRYQRPDLLLFQRFTLEKMEWPNH 369

  Fly   375 YCFQKFFPILTRWQVQQSK---QEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQI 436
            |..:|...:||.:.:.:.|   :....:||..|:|.|...||...|:.|..|...   .:.|||.
Human   370 YACEKLLVLLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHY---AMEDKQH 431

  Fly   437 AEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKENEPN- 500
            .|:          ...|||...:.|.|||::||.:.|.|.:...|   |:|....:||...||:
Human   432 GEF----------ALLTIEEESLFEAAYPEIVAVYQKQKLEIKGK---KQKRIKPKENNLPEPDE 483

  Fly   501 --SKPKRVVRKIKAQPEENQPLLHQFLGRKKEGTPVKAPAPQRQQCSTPITKFLPSDLESDC-DA 562
              |....:..|...:      :.|:...:...|.......||....::..:..||.:  :.| :|
Human   484 VMSFQSHMTLKPTCE------IFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKN--TPCLNA 540

  Fly   563 EEFDMSDI-------VKGIISNPNAKPALTNHDGHQLHYEPMAEDLSLRLAQMSLGNVNESPKVE 620
            :|..||.:       :|.:..:..::.:..|...|.:   .:..||.|........:.:.||.::
Human   541 QEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNI---SVIADLHLSTIDWEGTSFSNSPAIQ 602

  Fly   621 TKRDLSQVDQLPQSKRFSLEDSFDLLVKGDLQKLARTPVERFKMQHRISEKIPTPVKPLDNISYF 685
            .......:....:|:..::.|.|:     ::.:......||:..                ||...
Human   603 RNTFSHDLKSEVESELSAIPDGFE-----NIPEQLSCESERYTA----------------NIKKV 646

  Fly   686 FNQSSDNADVFEELMN--SSLVPQD 708
            .::.||.....|.|::  :.|..||
Human   647 LDEDSDGISPEEHLLSGITDLCLQD 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	143/399 (36%)
Gen	NP_647943.2	H3TH_GEN1	210..342	CDD:188625	45/144 (31%)
GEN1	NP_001123481.3	PIN_GEN1	2..206	CDD:350217	91/221 (41%)
		XPG-N domain. /evidence=ECO:0000269\|PubMed:26682650	2..96		43/96 (45%)
		XPG-I domain. /evidence=ECO:0000269\|PubMed:26682650	122..208		38/91 (42%)
		H3TH_GEN1	195..338	CDD:188625	45/144 (31%)
		5'-3' exonuclease domain. /evidence=ECO:0000269\|PubMed:26682650	208..384		51/178 (29%)
		Chromodomain. /evidence=ECO:0000269\|PubMed:26682650	390..464		25/86 (29%)
		Chromo_2	398..458	CDD:376128	23/72 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144337
Domainoid	1	1.000	84	1.000	Domainoid score	I8279
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2978
Isobase	1	0.950	-	0	Normalized mean entropy	S5877
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1094524at2759
OrthoFinder	1	1.000	-	-		FOG0005192
OrthoInspector	1	1.000	-	-		oto90116
orthoMCL	1	0.900	-	-		OOG6_106696
Panther	1	1.100	-	-	LDO	PTHR11081
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4810
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.710