Protein Alignment Gen and xpg-1

DIOPT Version :10

• Sequence 1: NP_647943.2
• Gene: Gen / 38594
• FlyBaseID: FBgn0263831
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_491891.2
• Gene: xpg-1 / 186441
• WormBaseID: WBGene00019004
• Length: 820
• Species: Caenorhabditis elegans
• Alignment Length: 559
• Identity: 136/559 - (24%)
• Similarity: 204/559 - (36%)
• Gaps: 194/559 - (34%)

  Fly    65 EQVTPVFVLEGVAPKL--------KSQVIAKRNELQF---RGVKPKNSPECTQSQPS-------- 110
            |.|....:||..|..|        |.:|.::..|:::   |..||.     |.|.|:
 Worm   397 EMVLQEVLLETAAKSLDKRMASLEKHKVPSEDEEIEWDPQRYDKPS-----TSSAPALMEDYIHL 456

  Fly   111 ----KGDKGRSRFNHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYG 171
                :.||....:    :..:..|.:.||..::.||||||.|..|.:.||||||:|.|||.:|:|
 Worm   457 NYSDEDDKTPELY----RDLQEFLTNAGIPWIESPGEAEAQCVELERLGLVDGVVSDDSDVWAFG 517

  Fly   172 AVRVYR-----NFSVSTQGAQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGG 231
            |..|||     |..|...|.|..|.        |:........::..|.:|||.|.|||. |:..
 Worm   518 AQHVYRHMFSKNRRVQRYGEQTTAN--------RDNCKLFCLQREDYISIALLSGGDYCA-GLVK 573

  Fly   232 IGKDGVLKLFNKYKETEILDRMRSWRGETDKYNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVC 296
            :|..|.|:|.::|.|..|           |..|.|:: ::::                     :.
 Worm   574 VGAIGALELVSEYVECRI-----------DNTNDLKV-IENR---------------------IM 605

  Fly   297 RTHKGCDESLW----KEQRLSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTI----------P 347
            |..|.. |||:    .::|::.::.:.|||....:.|..|.:.:.   |..|.:          .
 Worm   606 RLLKNV-ESLFLTAPDDKRVASRNAMMLRRHVTEANDMENIKCVC---SNQDAVHAYLHPIVDSS 666

  Fly   348 NLNLNWRQPNLVKFIKQIGH-LLQWPE----------IYCFQKFFPILTRWQVQQSKQEKILIQP 401
            :..|.|||.| :..|::|.| .||||:          ...|:|:...|......|.:.::...|
 Worm   667 SEKLRWRQMN-IPLIRRILHQRLQWPDRKQHNEEQNSFDAFEKWNNFLKSGGQSQMRLDRFFAQ- 729

  Fly   402 HEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQIAEYEAEHPKGIEELYYTIEPLDMLETAYPD 466
                     |...||||:|            .|:|                 :|.||.:    ..
 Worm   730 ---------KLDSSLELKW------------SKKI-----------------VEALDKI----GQ 752

  Fly   467 LVAAFLK----SKEKPAKKTTRKKKTASEEENKENEPNSKPKRVVRKIKAQPEENQPLLHQFLGR 527
            .||..:|    ||||...|..:|.|||             .|||.|.             :.:||
 Worm   753 RVAGTMKNNEMSKEKKVDKQIKKSKTA-------------VKRVTRA-------------RGIGR 791

  Fly   528 KKEGTPVKAPAPQRQQCSTPITKFLPSDLESDCDAEEFD 566
            .|.|. :..||..:...|           |.....:.||
 Worm   792 GKGGA-LLVPANSKLNLS-----------EESSSNDSFD 818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	2..207	CDD:350217	50/169 (30%)
		H3TH_GEN1	210..342	CDD:188625	30/135 (22%)
		Chromo_2	400..473	CDD:465841	14/72 (19%)
xpg-1	NP_491891.2	rad2	1..>249	CDD:273166
		PIN_XPG_RAD2	2..>105	CDD:350216
		rad2	<460..727	CDD:273166	83/317 (26%)
		PIN_XPG_RAD2	<464..>535	CDD:350216	30/74 (41%)