Protein Alignment Gen and ercc5

DIOPT Version :10

• Sequence 1: NP_647943.2
• Gene: Gen / 38594
• FlyBaseID: FBgn0263831
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: XP_012811722.1
• Gene: ercc5 / 100124735
• XenbaseID: XB-GENE-960380
• Length: 1251
• Species: Xenopus tropicalis
• Alignment Length: 919
• Identity: 166/919 - (18%)
• Similarity: 279/919 - (30%)
• Gaps: 372/919 - (40%)

  Fly     1 MGVKELWGVLTPHCERKPIN--ELRGKKVAIDLAGWVCESL--------NVVDYFVHPRHHLKNL 55
            |||:.||.:|  .|..:|||  .|.||.:|||::.|:.:::        |.:.     ..||..|
 Frog     1 MGVQGLWKLL--ECTGRPINAETLEGKILAIDISIWLNQAVKGARDRQGNAIQ-----NAHLLTL 58

  Fly    56 FFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFN 120
            |.|.|.|::.::.|:||.:|.||.||.|.:|||.                |.:.:..::.:....
 Frog    59 FHRLCKLLFFRIRPIFVFDGEAPLLKRQTLAKRR----------------QRKDNASNEAKKTHE 107

  Fly   121 HVLKQCETLLLSMGIQCV-----QGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFS 180
            .:|:   |.|....|:..     |...|..::.....|         :..|.:....:.....:|
 Frog   108 KLLR---TFLKRQAIKAALSGNKQSNDELPSFSKVRRK---------ETDDLYILPPLEDNEKYS 160

  Fly   181 VSTQGAQA----------------AAGGAVDI-----------------YDMREITSRM------ 206
            ...:..:|                |...:|||                 .||:|.|.|.
 Frog   161 SEEEEERAWEERMTQKQRLQEEFFANPSSVDIESEEFISLPPEVKHEILTDMKEFTKRRRTLFEA 225

  Fly   207 ------DFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKYKETEILDRMRSWRG-----ET 260
                  ||.|.::..:......:.|        .|.|.|..|:....|:..:..:..|     ||
 Frog   226 MPEDSNDFSQYQLSGLLKKNNLNKC--------IDNVRKELNQQYSGEVQAQFEAEGGFLKEVET 282

  Fly   261 DK-----------YNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKGCDESLWKEQRLSI 314
            .:           ...::.:.::|.:.|      ..||.|.:.....:|:            |.:
 Frog   283 RRLVSEDNSHYILIKGIQSKKEEKKVDS------PPQSVTYNSSQTPKTY------------LDL 329

  Fly   315 KSELTLRRKALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQIGHLLQWPEIYCFQK 379
            |  |...|||..|.....:|       ||.:                          |.
 Frog   330 K--LASARKAKSSQAASADE-------EPPS--------------------------PR------ 353

  Fly   380 FFPILTRWQVQQSKQEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQIAEYEAE-H 443
                 |.:.:|::..|.|                  |:..|.|.    |...|...:.|.|.. .
 Frog   354 -----TLFAIQEAMTENI------------------LDENWDDE----KHEKPSVSVREAEGNVS 391

  Fly   444 PKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKENEPNSKPKRVVR 508
            |:.::.:|..:                   ::::..:...:|....||.|:|      |.|.:|
 Frog   392 PRTLQAIYQVL-------------------AEDEAGQSNKKKTVVQSEREHK------KAKVIV- 430

  Fly   509 KIKAQPEENQPLLHQFLGRKKE--GTP-VKAPAPQRQQC-STPITKFLPSDLESDCDAEEFDMSD 569
             |.:..||:..|.:|  ||.|.  |.| :...:|...|| .:.::..|      || |....:|.
 Frog   431 -ISSSDEEDNCLNNQ--GRTKAAFGVPLINRVSPSSVQCQESAVSSVL------DC-AHSRSVSQ 485

  Fly   570 IVKGIISNPNAKPALTNHDGHQLHYE----PMAEDLSLRLAQMSLGN-------------VNESP 617
                 :..|:.:..:.....|.|..:    |:|:|  ..:...|.||             .:|.|
 Frog   486 -----VEEPSNEVNVVEMADHNLQLDNRNVPIAQD--TLIVSSSTGNAENPVTLCNTIPVTSEIP 543

  Fly   618 KVETKRDLSQVDQLPQSKRFSLEDSFDLLVKGDLQK----------------------------- 653
            .:...|.:.:....|.:.. |.:.|.|:.::||..|
 Frog   544 LLSVNRSIQKSVINPYNSG-SFDSSRDISLQGDANKQGFSDNPVVDVLNSPFETALKSSSALGES 607

  Fly   654 ----------------------------LARTPVE-RFKMQHRISEKIPTPVKPL---------- 679
                                        |.::|.| ..|....:||...||...|
 Frog   608 SNTLATQLLLSKSNKFSDPSMGQSCSNTLLKSPFETALKSSSALSESSNTPATQLLLSKSNKYSD 672

  Fly   680 ------------------------------DNISYFFNQSSDNADVFEELMNSSLVPQDQE---D 711
                                          ||.......|:|:..|:..:...|::..|:|   |
 Frog   673 ASMVQGCSNTLEVTQVIQPSAGSEVKQPAEDNPPMKVLGSNDSGGVYVPMTPESIIVSDEEICDD 737

  Fly   712 NAEDEEEDD 720
            ..||.:.||
 Frog   738 KKEDSDSDD 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	2..207	CDD:350217	56/264 (21%)
		H3TH_GEN1	210..342	CDD:188625	24/147 (16%)
		Chromo_2	400..473	CDD:465841	9/73 (12%)
ercc5	XP_012811722.1	rad2	1..1112	CDD:273166	166/919 (18%)