Protein Alignment Tie and TIE1

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_005415.1
• Gene: TIE1 / 7075
• HGNCID: 11809
• Length: 1138
• Species: Homo sapiens
• Alignment Length: 962
• Identity: 234/962 - (24%)
• Similarity: 349/962 - (36%)
• Gaps: 263/962 - (27%)

  Fly   355 PGGLTIKAAEGDDDHPRVL----EVSVAQSTTPTITTTST-TPAPVSSTRPTASTRRPLTPVERS 414
            |.|......|..|..|::|    |:.....|.|.|...:. .|.||   |.:...|:|...|
Human   336 PSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPV---RGSIELRKPDGTV--- 394

  Fly   415 RSKYKYHMRERGLVPTAA--PPPAAPPAPPVSRTRYVGSGRPTAGLSDS-IQDLKQTESEVAKPV 476
                        |:.|.|  .|........|.|.....||.....:|.| .||.::.:..|..|.
Human   395 ------------LLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPP 447

  Fly   477 VRRVVQKVSPSSSTPLIITVL---SAEEETTVGQTEALPTDESTTTTST---------TTTTEKP 529
            |.....::....|..|:::.|   |.:...:..:....|.| ||...||         |....:|
Human   448 VPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQD-STMDWSTIVVDPSENVTLMNLRP 511

  Fly   530 STTTSTSTTTTTP--------VPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPT 586
            .|..|.....:.|        .|.|...|....||.   .|.........:.....|.|..::|
Human   512 KTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLL---QPWLEGWHVEGTDRLRVSWSLPLVP- 572

  Fly   587 TTKANSIIEKDKELIR----ALGPALTREINIDDANNLIVFCNNTSDCGVTPRT----QTQPSHT 643
                 ..:..|..|:|    ..|......::...|...::       .|:||.|    ..|..|.
Human   573 -----GPLVGDGFLLRLWDGTRGQERRENVSSPQARTALL-------TGLTPGTHYQLDVQLYHC 625

  Fly   644 TDSSPKILRTTVLTSIRSTVHPRPTSTSTTTST----TTTAPPAVTAPSNEVYIGIVESSSSASP 704
            |...|......||........||.......:.:    |...|.|:..|.::..:.:..:..:..|
Human   626 TLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDP 690

  Fly   705 ADI-------SSTVIANERDLNMEMR---RM-----------NLV-------------------- 728
            ..|       :||:|   |.||...|   ||           |.|
Human   691 LWIDVDRPEETSTII---RGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRA 752

  Fly   729 -------TLVLVAVGVIPLAAI-ILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQV 785
                   .|:|..||.:....: ||..:...|..||:        |:..::..:        ||.
Human   753 AEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRS--------CLHRRRTFT--------YQS 801

  Fly   786 DDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFE 850
            ...|:.:       :|..............|..|:|                        :...|
Human   802 GSGEETI-------LQFSSGTLTLTRRPKLQPEPLS------------------------YPVLE 835

  Fly   851 RSNIRLKSLLGEGNFGQVWKA--EADDLSGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKL 910
            ..:|..:.|:||||||||.:|  :.|.|..:      .|:|.::..:::...:|   |..::.||
Human   836 WEDITFEDLIGEGNFGQVIRAMIKKDGLKMN------AAIKMLKEYASENDHRDFAGELEVLCKL 894

  Fly   911 GSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNIL---PASVPGGRSLAPLSPRT 972
            |.|.|::.|||||.......:.:|||..|.||..||.:|    :|   ||......:.:.||.|.
Human   895 GHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSR----VLETDPAFAREHGTASTLSSRQ 955

  Fly   973 LAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAAND 1037
            |..||.|.|.||:|::.::.:||||||||||:..|...||.|||:|        |.|:.
Human   956 LLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLS--------RGEEV------ 1006

  Fly  1038 LMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMA 1102
                            |:                         ||      |:|:   ||:||||
Human  1007 ----------------YV-------------------------KK------TMGR---LPVRWMA 1021

  Fly  1103 PESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLM 1167
            .|||.|.::||::|:|:||::||||.:||.|||..:|..|:..::|||.|.:.|:....|.|.||
Human  1022 IESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELM 1086

  Fly  1168 SRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGV 1219
            .:||...|:.||.|||..|::.|.|       .|...|:::|.|......|:
Human  1087 RQCWRDRPYERPPFAQIALQLGRML-------EARKAYVNMSLFENFTYAGI 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	116/336 (35%)
TIE1	NP_005415.1	ig	129..210	CDD:395002
		EGF_CA	227..256	CDD:238011
		EGF_2	321..344	CDD:400365	2/7 (29%)
		Ig	350..441	CDD:472250	25/108 (23%)
		Ig strand B	368..372	CDD:409556	2/3 (67%)
		Ig strand C	384..388	CDD:409556	0/3 (0%)
		Ig strand E	409..413	CDD:409556	0/3 (0%)
		Ig strand F	423..428	CDD:409556	0/4 (0%)
		Ig strand G	436..439	CDD:409556	0/2 (0%)
		fn3	452..536	CDD:394996	16/84 (19%)
		fn3	548..632	CDD:394996	17/96 (18%)
		FN3	644..736	CDD:238020	19/94 (20%)
		PTKc_Tie1	836..1132	CDD:270671	126/377 (33%)