DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and AXL

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_068713.2 Gene:AXL / 558 HGNCID:905 Length:894 Species:Homo sapiens


Alignment Length:479 Identity:131/479 - (27%)
Similarity:199/479 - (41%) Gaps:143/479 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   733 VAVGVIPLAAIILYLVRNFVIRRRAKQS---EVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDH 794
            |.:|.:..||.:|.|.. |::.||.|::   |||       :|.....::..:|:|         
Human   453 VLLGAVVAAACVLILAL-FLVHRRKKETRYGEVF-------EPTVERGELVVRYRV--------- 500

  Fly   795 QHHQHMQHHQNHQNHQNHQHHQAMPMSQASQR--DANHNRYGNNDDKTSLASEFHD--FERSNIR 855
                                     ....|:|  :|..|..|.:::   |..:..|  .:|..:.
Human   501 -------------------------RKSYSRRTTEATLNSLGISEE---LKEKLRDVMVDRHKVA 537

  Fly   856 LKSLLGEGNFGQVWKAE--ADDLSGHFGATRIVAVKTIR-ACSAQVSLKD---EANIMRKLGSHQ 914
            |...||||.||.|.:.:  .||      :...|||||:: |...:..|:|   ||..|::. .|.
Human   538 LGKTLGEGEFGAVMEGQLNQDD------SILKVAVKTMKIAICTRSELEDFLSEAVCMKEF-DHP 595

  Fly   915 NVVTLLGACV-----ESEP-HMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTL 973
            ||:.|:|.|.     ||.| .::|:.:...|.|.|.|..:|....  |..:|         .:.|
Human   596 NVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQ--PVYLP---------TQML 649

  Fly   974 AGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDL 1038
            ..|..|||.||||::.:|.:||||||||.:|:.|....:.|||:|             |...|  
Human   650 VKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLS-------------KKIYN-- 699

  Fly  1039 MRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAP 1103
                                     |....||..:|                     :|::|:|.
Human   700 -------------------------GDYYRQGRIAK---------------------MPVKWIAI 718

  Fly  1104 ESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMS 1168
            |||...::|:::|:|:||:.:|||||.|.|||..:...|:...:.||.|...|.:.....|.|||
Human   719 ESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMS 783

  Fly  1169 RCWHKEPHMRPSFAQSRLEITRSL 1192
            |||...|..||||.:.|.::..:|
Human   784 RCWELNPQDRPSFTELREDLENTL 807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 105/340 (31%)
AXLNP_068713.2 interaction with Gas6 26..92
IgI_1_Axl_like 35..135 CDD:409558
Ig strand A 35..40 CDD:409558
Ig strand A' 43..46 CDD:409558
Ig strand B 50..60 CDD:409558
Ig strand C 66..71 CDD:409558
Ig strand C' 74..76 CDD:409558
Ig strand D 81..88 CDD:409558
Ig strand E 95..106 CDD:409558
Ig strand F 113..121 CDD:409558
Ig strand G 124..135 CDD:409558
IgI_2_Axl_Tyro3_like 140..222 CDD:409407
Ig strand A 140..143 CDD:409407
Ig strand A' 146..150 CDD:409407
Ig strand B 154..163 CDD:409407
Ig strand C 168..175 CDD:409407
Ig strand C' 177..180 CDD:409407
Ig strand E 186..197 CDD:409407
Ig strand F 200..209 CDD:409407
Ig strand G 213..222 CDD:409407
FN3 225..328 CDD:238020
fn3 335..418 CDD:394996
PTKc_Axl 535..811 CDD:270660 107/352 (30%)
Blue background indicates that the domain is not in the aligned region.

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