DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tie and Flt1

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_062179.2 Gene:Flt1 / 54251 RGDID:2621 Length:1336 Species:Rattus norvegicus


Alignment Length:1320 Identity:290/1320 - (21%)
Similarity:449/1320 - (34%) Gaps:458/1320 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 VALLLAEAIVAA---AAATLSETQTNATNGAIREPPVQLQLQQQQLQLQLQLNAT-AGDGESRNS 137
            :.||..||.|..   ..:.|:..|||........||..::..:.|   .|.||.| ..|..:|..
  Rat   202 IGLLTCEATVNGHLYQTSYLTHRQTNTILDVQISPPSPVRFLRGQ---TLVLNCTVTTDLNTRVQ 263

  Fly   138 AEIFSPGDVDVVGDKPTTYRPSGANR-----------PSIAPLNSAQDRERKLMNVLAARRTALH 191
            .....||        ..|.|.|...|           .|:..:|:.:.|::.|...         
  Rat   264 MSWNYPG--------KATKRASIRQRIDQSNPHSNVFHSVLKINNVESRDKGLYTC--------- 311

  Fly   192 RGGFRTRIGTTGRTAISPSAAVESTSKAPSDPRSVCIRNCTKNFTRRTTASCMRQCANFTRMAMP 256
                |.:.|::.||.        :||....:...:.::: .|...:.|.|.......:....|.|
  Rat   312 ----RVKSGSSFRTF--------NTSVHVYEKGFISVKH-RKQQVQETIAGKRSHRLSMKVKAFP 363

  Fly   257 SNGNSSVVLKGSASLKAAAPAGDRDTNEILFSDESSHGLFVVAKEQNGTLNHIAD-----GTKPA 316
            |   ..||.     ||...||.::...      .|.||..::.|:.  |.....|     |.|.:
  Rat   364 S---PEVVW-----LKDGVPATEKSAR------YSVHGYSLIIKDV--TAEDAGDYTILLGIKQS 412

  Fly   317 VMGKGIPSKTNSMEDDVEEEEDELKPYVY----FGAKLPPIRPGGLTIKAAEGDDDHPRVLEVSV 377
            .:.:.:   |.::..:|       ||.:|    .....||:.|.|           ..:||..:|
  Rat   413 KLFRNL---TATLIVNV-------KPQIYEKSVSSLPSPPLYPLG-----------SRQVLTCTV 456

  Fly   378 AQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSRSKYKYHMRERGLVPTAAPPPAAPPAPP 442
            .....|||... ..|...:.:              :.|:.:.:...|..::.:::          
  Rat   457 YGIPQPTIKWL-WHPCHYNHS--------------KERNDFCFGSEESFILDSSS---------- 496

  Fly   443 VSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQ 507
                   ..|....|::..:..::.|...|:..||        ..|.||.|.:..:..:..||.:
  Rat   497 -------NIGNRIEGITQRMMVIEGTNKTVSTLVV--------ADSRTPGIYSCKAFNKIGTVER 546

  Fly   508 ----------------TEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPL 556
                            .|.:||:......|..                   |.....|..|...|
  Rat   547 DIRFYVTDVPNGFHVSLEKIPTEGEDLKLSCV-------------------VSKFLYRDITWILL 592

  Fly   557 STTNTPTTTTSSTTPSTTTTSSTSTT---VIPTTTKANS---------------IIEKDKELIRA 603
            .|.|..|...|.:.....||...|.|   ||...:..:|               |:.|.:.|:|.
  Rat   593 RTVNNRTMHHSISKQKMATTQDYSITLNLVIKNVSLEDSGTYACRARNIYTGEEILRKTEVLVRD 657

  Fly   604 L-GPALTREINIDDANNLIVFCNNTSDC---GV-TPR-TQTQPSHTTDSSPKILRTTVLTSIRST 662
            | .|.|.:  |:.| :.:.:..:.|.||   || .|: |..:.:|.....|.|:           
  Rat   658 LEAPLLLQ--NLSD-HEVSISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGII----------- 708

  Fly   663 VHPRPTSTSTTTSTTTTAPPAVTAPSNEVY-------IGIVESSSSASPADISSTVIANERDLNM 720
            :.|         ..:|.....||.....||       .|:||||:..       ||.......|:
  Rat   709 LGP---------GNSTLFIERVTEEDEGVYRCRATNQKGVVESSAYL-------TVQGTSDKSNL 757

  Fly   721 EMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQV 785
            |     |:||....|     ||.:.:|:....||:..:.|             |.||.......:
  Rat   758 E-----LITLTCTCV-----AATLFWLLLTLFIRKLKRSS-------------SEVKTDYLSIIM 799

  Fly   786 DDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFE 850
            |.||..:|.|                   .:.:|..                     ||:: :|.
  Rat   800 DPDEVPLDEQ-------------------CERLPYD---------------------ASKW-EFA 823

  Fly   851 RSNIRLKSLLGEGNFGQVWKAEADDLSGHFG-----ATRIVAVKTIR---ACSAQVSLKDEANIM 907
            |..::|...||.|.||:|.:|.|      ||     ..|.||||.::   ..|...:|..|..|:
  Rat   824 RERLKLGKSLGRGAFGKVVQASA------FGIKKSPTCRTVAVKMLKEGATASEYKALMTELKIL 882

  Fly   908 RKLGSHQNVVTLLGACV-ESEPHMLIMEYAMRGRLLSLLRAAR--------SATNILP------- 956
            ..:|.|.|||.|||||. :..|.|:|:||...|.|.:.|::.|        :|.::.|       
  Rat   883 THIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDFFCLNKDAALHMEPKKEKLEP 947

  Fly   957 ------------------------------ASVPGGR-----SLAPLSPRTLAGFALDIACGMEY 986
                                          :.|.||.     |..||:...|..::..:|.|||:
  Rat   948 DLEQDQKPRLDSVSSSESFTSSGFQEDKSVSDVEGGEDYSEISKQPLTMEDLISYSFQVARGMEF 1012

  Fly   987 IAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFG 1051
            ::.|:.:||||||||:||..|.:.||||||::.|:         .||.  |.:|..         
  Rat  1013 LSSRKCIHRDLAARNILLSENNVVKICDFGLARDI---------YKNP--DYVRRG--------- 1057

  Fly  1052 SRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETD 1116
                                                ||     .||::||||||:...:::|::|
  Rat  1058 ------------------------------------DT-----RLPLKWMAPESIFDKVYSTKSD 1081

  Fly  1117 IWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPS 1180
            :|::|::||||.:||.:||..: ...:...|:.:|:|...|:.:..|.|.:|..||||:|..||.
  Rat  1082 VWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPR 1146

  Fly  1181 FAQSRLEITRSLHKWVDDDSAASDYM--------------DVSGFSEDL--------------EH 1217
            ||:...::...|...|..|  ..||:              .|..||||.              ..
  Rat  1147 FAELVEKLGDLLQANVQQD--GKDYIPLNAILTRNSGFTYSVPTFSEDFFKDGFTDPKFHSGSSD 1209

  Fly  1218 GVVYFN-------HRISEFE 1230
            .|.|.|       .||..||
  Rat  1210 DVRYVNAFKFMSLERIKTFE 1229

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 112/388 (29%)
Flt1NP_062179.2 IG_like 143..219 CDD:214653 5/16 (31%)
Ig 231..330 CDD:472250 25/130 (19%)
Ig strand B 248..252 CDD:409353 2/3 (67%)
Ig strand C 263..267 CDD:409353 0/3 (0%)
Ig strand E 294..298 CDD:409353 1/3 (33%)
Ig strand F 308..313 CDD:409353 1/17 (6%)
Ig strand G 321..324 CDD:409353 1/10 (10%)
Ig 333..424 CDD:472250 21/110 (19%)
Ig strand B 353..357 CDD:409353 0/3 (0%)
Ig strand C 366..370 CDD:409353 2/8 (25%)
Ig strand E 388..392 CDD:409353 0/3 (0%)
Ig strand F 402..407 CDD:409353 1/4 (25%)
Ig strand G 417..420 CDD:409353 0/5 (0%)
Ig 447..552 CDD:472250 22/155 (14%)
Ig strand B 450..454 CDD:409353 2/3 (67%)
Ig strand C 463..467 CDD:409353 2/3 (67%)
Ig strand E 515..519 CDD:409353 1/3 (33%)
Ig strand F 532..537 CDD:409353 1/4 (25%)
Ig strand G 545..548 CDD:409353 0/2 (0%)
IG_like 568..640 CDD:214653 17/90 (19%)
Ig strand B 573..577 CDD:409353 0/3 (0%)
Ig strand C 586..594 CDD:409353 2/7 (29%)
Ig strand E 619..623 CDD:409353 0/3 (0%)
Ig strand F 633..638 CDD:409353 0/4 (0%)
I-set 661..748 CDD:400151 25/116 (22%)
Ig strand B 679..682 CDD:409353 1/2 (50%)
Ig strand C 691..695 CDD:409353 1/3 (33%)
Ig strand E 714..718 CDD:409353 1/3 (33%)
Ig strand F 728..733 CDD:409353 2/4 (50%)
Protein Kinases, catalytic domain 819..1157 CDD:473864 115/405 (28%)

Return to query results.
Submit another query.